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Bidyut Chakrobarty
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The role of tobacco, virus and genes in oral cancer.

he prevalence of oral squamous cell carcinoma (OSCC) has significantly increased over decades in several countries and human papilloma virus (HPV) has been indicated as one of the underlying causes. This suggests that HPV plays a role in the early stages of carcinogenesis but is not a requisite for the maintenance and progression of malignant state. p53 is a tumor suppressor gene that checks the cell and promotes apoptosis and cell repair that can be deactivated by mutations and a viral interaction leading to cancer and individuals with particular polymorphic variant of p53 is more susceptible to HPV-induced carcinogenesis. The present study has been carried out to detect and correlate p53 polymorphism/mutation, HPV DNA in the biopsy samples of oral cancer patients who had tobacco habits.

The article was published by
El artículo fue publicado por
Journal of Oral and Maxillofacial Pathology (JOMFP)
Volume / Volumen: 18
Number / Número: 2
First and last pages / Páginas inicial-final: 211-216
Year / Año: 2014
Month / Mes: may

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Principal institution where the research took place
Institución principal de la investigación
Dr. R Ahmed Dental College, Kolkata,, West Bengal, India

Author's Report

Crónica del Autor

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Other articles written by the author Bidyut Chakrobarty
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Bidyut Chakrobarty was invited by SIIC on
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Relationship Among Tobacco Habits, Human Papilloma Virus (HPV) Infection, P53 Polymorphism/Mutation and the Risk of Oral Squamous Cell Carcinoma

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Bidyut Chakrobarty1, Jay Gopal Ray2, Divya Uppala3, Sumit Majumdar4

4 Dr, Gitam Dental College, Head Of The Department

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