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Jesus Munoz-Estrada
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DISC1 (disrupted-in-schizophrenia-1) is considered a genetic risk factor for neuropsychiatric disorders. In this study, analysis in human olfactory neuronal precursors of schizophrenia and bipolar disorder patients showed decreased DISC1 levels in the cytoplasm, cAMP accumulation and diminished cell migration. The results suggest that these disorders share common molecular pathways that could hinder the neurodevelopmental process.

The article was published by
El artículo fue publicado por
CNS Neuroscience & Therapeutics
Volume / Volumen: 21
Number / Número: 5
First and last pages / Páginas inicial-final: 446-453
Year / Año: 2015
Month / Mes: may

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integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

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Bibliographic references
Referencias bibliográficas

Green MF. Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry 67:e12, 2006.
Yuksel C, McCarthy J, Shinn A, et al. Gray matter volume in schizophrenia and bipolar disorder with psychotic features. Schizophr Res 138:177-182, 2012.
De Peri L, Crescini A, Deste G, Fusar-Poli P, Sacchetti E, Vita A. Brain structural abnormalities at the onset of schizophrenia and bipolar disorder: A meta-analysis of controlled magnetic resonance imaging studies. Curr Pharm Des 18:486-494, 2012.
Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44:660-669, 1987.
Rapoport JL, Addington AM, Frangou S, Psych MR. The neurodevelopmental model of schizophrenia: Update 2005. Mol Psychiatry 10:434-449, 2005.
Sanches M, Keshavan MS, Brambilla P, Soares JC. Neurodevelopmental basis of bipolar disorder: A critical appraisal. Prog Neuropsychopharmacol Biol Psychiatry 32:1617-1627, 2008.
Schmitt A, Malchow B, Hasan A, Falkai P. The impact of environmental factors in severe psychiatric disorders. Front Neurosci 8:19, 2014. Morris JA, Kandpal G, Ma L, Austin CP. DISC1 (disrupted-in-schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: Regulation and loss of interaction with mutation. Hum Mol Genet 12:1591-1608, 2013.
Ozeki Y, Tomoda T, Kleiderlein J, et al. Disrupted-in-schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci USA 100:289-294, 2003.
Wang Q, Brandon NJ. Regulation of the cytoskeleton by Disrupted-in-schizophrenia 1 (DISC1). Mol Cell Neurosci 48:359-364, 2011.
Morris NR, Efimov VP, Xiang X. Nuclear migration, nucleokinesis and lissencephaly. Trends Cell Biol 8:467-470, 1998.
Lambert de Rouvroit C, Goffinet AM. Neuronal migration. Mech Dev 105:47-56, 2001.
Hatten ME. Motility and cytoskeletal organization of migrating cerebellar granule neurons. J Neurosci 15:981-989, 1995.
Schaar BT, McConnell SK. Cytoskeletal coordination during neuronal migration. Proc Natl Acad Sci USA 102:13652-13657, 2005.
Rioux L, Ruscheinsky D, Arnold SE. Microtubule-associated protein MAP2 expression in olfactory bulb in schizophrenia. Psychiatry Res 128:1-7, 2004. Rosoklija G, Keilp JG, Toomayan G, et al. Altered subicular MAP2 immunoreactivity in schizophrenia. Prilozi 26:13-34, 2005. Sawamura N, Ando T, Maruyama Y, et al. Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Mol Psychiatry 13:1138-1148, 2008.
Soda T, Frank C, Ishizuka K, et al. DISC1-ATF4 transcriptional repression complex: Dual regulation of the cAMP-PDE4 cascade by DISC1. Mol Psychiatry 18:898-908, 2013. Leterrier JF, Kurachi M, Tashiro T, Janmey PA. MAP2-mediated in vitro interactions of brain microtubules and their modulation by cAMP. Eur Biophys J 38:381-393, 2009.
Lebel M, Patenaude C, Allyson J, Massicotte G, Cyr M. Dopamine D1 receptor activation induces tau phosphorylation via cdk5 and GSK3 signaling pathways. Neuropharmacology 57:392-402, 2009.
Vrotsos EG, Sugaya K. MCP-1-induced migration of NT2 neuroprogenitor cells involving APP signaling. Cell Mol Neurobiol 29:373-381, 2009.
Sawamura N, Sawamura-Yamamoto T, Ozeki Y, Ross CA, Sawa A. A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc Natl Acad Sci USA 102:1187-1192, 2005. Graziadei PP, Monti Graziadei GA. Neurogenesis and plasticity of the olfactory sensory neurons. Ann NY Acad Sci 457:127-142, 1985.
Murrell W, Bushell GR, Livesey J, et al. Neurogenesis in adult human. Neuro Report 7:1189-1194, 1996.
Arnold SE, Smutzer GS, Trojanowski JQ, Moberg PJ. Cellular and molecular neuropathology of the olfactory epithelium and central olfactory pathways in Alzheimer's disease and schizophrenia. Ann NY Acad Sci 855:762-775, 1998.
Cascella NG, Takaki M, Lin S, Sawa A. Neurodevelopmental involvement in schizophrenia: The olfactory epithelium as an alternative model for research. J Neurochem 102:587-594, 2007.
McCurdy RD, Feron F, Perry C, et al. Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophr Res 82:163-173, 2006.
Benitez-King G, Riquelme A, Ortiz-Lopez L, et al. A non-invasive method to isolate the neuronal linage from the nasal epithelium from schizophrenic and bipolar diseases. J Neurosci Methods 201:35-45, 2011.
Solis Chagoyan H, Calixto E, Figueroa A, et al. Microtubule organization and L-type voltage-activated calcium current in olfactory neuronal cells obtained from patients with schizophrenia and bipolar disorder. Schizophr Res 143:384-389, 2013.
American Psychiatric Association. DSM-IV Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Press, 1994.
Perez Yepez EA, Ayala Sumuano JT, Reveles Espinoza AM, Meza I. Selection of a MCF-7 breast cancer cell subpopulation with high sensitivity to IL-1beta: Characterization of and correlation between morphological and molecular changes leading to increased invasiveness. Int J Breast Cancer 2012:609148, 2012.
Andrews NC, Faller DV. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res 19:2499, 1991.
Osorio Espinoza A, Escamilla Sanchez J, Aquino Jarquin G, Arias Montano JA. Homologous desensitization of human histamine H(3) receptors expressed in CHO-K1 cells. Neuropharmacology 77:387-397, 2014.
Ishizuka K, Paek M, Kamiya A, Sawa A. A review of Disrupted-in-schizophrenia-1 (DISC1): Neurodevelopment, cognition, and mental conditions. Biol Psychiatry 59:1189-1197, 2006.
Tohda M, Nomura Y. Neurochemical and morphological studies on differentiation of NG108-15 cells by phorbol ester and forskolin. Neurochem Int 13:37-42, 1988.
Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK. The DISC locus in psychiatric illness. Mol Psychiatry 13:36-64, 2008.
Mackie S, Millar JK, Porteous DJ. Role of DISC1 in neural development and schizophrenia. Curr Opin Neurobiol 17:95-102, 2007.
Millar JK, Wilson-Annan JC, Anderson S, et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 9:1415-1423, 2000.
Reynolds R, Herschkowitz N. Selective uptake of neuroactive amino acids by both oligodendrocytes and astrocytes in primary dissociated culture: A possible role for oligodendrocytes in neurotransmitter metabolism. Brain Res 371:253-266, 1986.
Ray J, Peterson DA, Schinstine M, Gage FH. Proliferation, differentiation, and long-term culture of primary hippocampal neurons. Proc Natl Acad Sci USA 90:3602-3606, 1993.
Casalbore P, Budoni M, Ricci-Vitiani L, et al. Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1. PLoS ONE 4:e4434, 2009.
Horiuchi Y, Kano S, Ishizuka K, et al. Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders. Neurosci Res 77:247-250, 2013.
Lipska BK, Peters T, Hyde TM, et al. Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum Mol Genet 15:1245-1258, 2006.
Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J. Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons. J Neurosci 32:738-745, 2012.
Tomita K, Kubo K, Ishii K, Nakajima K. Disrupted-in-schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development. Hum Mol Genet 20:2834-2845, 2011.
Yang H, Ganguly A, Cabral F. Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs. J Biol Chem 285:32242-32250, 2010.
Chiaramello S, Dalmasso G, Bezin L, et al. BDNF/TrkB interaction regulates migration of SVZ precursor cells via PI3-K and MAP-K signalling pathways. Eur J Neurosci 26:1780-1790, 2007.
Boyd KN, Mailman RB. Dopamine receptor signaling and current and future antipsychotic drugs. Handb Exp Pharmacol 212:53-86, 2012.
Clement-Cormier YC, Kebabian JW, Petzold GL, Greengard P. Dopamine-sensitive adenylate cyclase in mammalian brain: A possible site of action of antipsychotic drugs. Proc Natl Acad Sci USA 71:1113-1117, 1974.

Other articles written by the author Jesus Munoz-Estrada
Otros artículos de Jesus Munoz-Estrada

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Jesus Munoz-Estrada was invited by SIIC on
Jesus Munoz-Estrada fue invitado por SIIC el
2015, august 6
  The author's report was accepted on
La crónica del autor fue aprobada el
2017, august 15
The author's report was accepted on
La crónica del autor fue aprobada el
2017, august 15
Published in siicsalud
Publicado en siicsalud
2017, november 13

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Neurología
Mental Health
/ Salud Mental

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Informática Biomédica

Genética Humana

Medical Education
Educación Médica


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Author / Autor
Jesus Munoz-Estrada1, Gloria Benitez-King2, Isaura Meza3

3 Phd

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CNS Neuroscience & Therapeutics

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