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ALTERED SUBCELLULAR DISTRIBUTION OF DISC1, CAMP LEVELS, AND NEURONAL MIGRATION IN SCHIZOPHRENIA AND BIPOLAR DISORDER

DISC1 (disrupted-in-schizophrenia-1) is considered a genetic risk factor for neuropsychiatric disorders. In this study, analysis in human olfactory neuronal precursors of schizophrenia and bipolar disorder patients showed decreased DISC1 levels in the cytoplasm, cAMP accumulation and diminished cell migration. The results suggest that these disorders share common molecular pathways that could hinder the neurodevelopmental process.

The article was published by
El artículo fue publicado por
CNS Neuroscience & Therapeutics
Volume / Volumen: 21
Number / Número: 5
First and last pages / Páginas inicial-final: 446-453
Year / Año: 2015
Month / Mes: may


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Principal institution where the research took place
Institución principal de la investigación
CENTRO DE INVETIGACION Y DE ESTUDIOS AVANZADOS DEL INSTITUTO POLITECNICO NACIONAL, Mexico, Ciudad de México, D.F., Mexico


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Bibliographic references
Referencias bibliográficas

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Other articles written by the author Jesus Munoz-Estrada
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Jesus Munoz-Estrada was invited by SIIC on
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2015, august 6
  The author's report was accepted on
La crónica del autor fue aprobada el
2017, august 15
The author's report was accepted on
La crónica del autor fue aprobada el
2017, august 15
Published in siicsalud
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2017, november 13





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Neurology
/ Neurología
 
Mental Health
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Bioinformatics
Informática Biomédica

Genetics
Genética Humana

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Educación Médica

Pharmacology
Farmacología

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ALTERED SUBCELLULAR DISTRIBUTION OF DISC1, CAMP LEVELS, AND NEURONAL MIGRATION IN SCHIZOPHRENIA AND BIPOLAR DISORDER


Author / Autor
Jesus Munoz-Estrada1, Gloria Benitez-King2, Isaura Meza3

3 Phd


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CNS Neuroscience & Therapeutics

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