Crónicas de autores

Alberto Ortiz *

Autor invitado por SIIC

El trabajo ilustra acerca de mecanismos moleculares y nuevas dianas terapéuticas en nefropatías

MUERTE CELULAR POR APOPTOSIS EN ENFERMEDAD RENAL

El conocimiento de los mecanismos moleculares de la muerte celular facilitará la intervención sobre nuevas dianas terapéuticas para las nefropatías.

*Alberto Ortiz
describe para SIIC los aspectos relevantes de su trabajo
MECHANISMS OF RENAL APOPTOSIS IN HEALTH AND DISEASE
Journal of the American Society of Nephrology,
19(9):1634-1642 Sep, 2008

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Universidad Autonoma Madrid, Madrid, España
Imprimir nota
Referencias bibliográficas
Green DR, Kroemer G. Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest 115:2610-7, 2005.
Riedl SJ, Salvesen GS. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 8:405-13, 2007.
Koseki C, Herzlinger D, al-Awqati Q. Apoptosis in metanephric development. J Cell Biol 119:1327-33, 1992.
Lorz C, Benito-Martin A, Justo P, Sanz AB, Sanchez Niño MD, Egido J, Ortiz A. Modulation of renal tubular cell survival: where is the evidence? Current Medicinal Chemistry 13:763-771, 2006.
Olsen TS, Olsen HS, Hansen HE. Tubular ultrastructure in acute renal failure in man: epithelial necrosis and regeneration. Virchows Arch A Pathol Anat Histopathol 406:75-89, 1985.
Shankland SJ. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 69:2131-47, 2006.
Hughes J, Savill JS. Apoptosis in glomerulonephritis. Curr Opin Nephrol Hypertens 14:389-95, 2005.
Shimizu A, Yamanaka N. Apoptosis and cell desquamation in repair process of ischemic tubular necrosis. Virchows Arch B Cell Pathol Incl Mol Pathol 64:171-80, 1993.
Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P, Zhivotovsky B, Blagosklonny MV, Malorni W, Knight RA, Piacentini M, Nagata S, Melino G. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ 12(Suppl.2):1463-7, 2005.
Padanilam BJ. Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol 284:F608-27, 2003.
Ashkenazi A, Dixit VM. Apoptosis control by death and decoy receptors. Curr Opin Cell Biol 11:255-60, 1999.
Thorburn A. Death receptor-induced cell killing. Cell Signal 16:139-44, 2004.
Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science 305:626-9, 2004.
Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 3:E255-63, 2001.
Ravagnan L, Roumier T, Kroemer G. Mitochondria, the killer organelles and their weapons. J Cell Physiol 192:131-7, 2002.
Vaux DL, Silke J. IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol 6:287-97, 2005.
Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G. Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle 5:2592-601, 2006.
Griffin SV, Olivier JP, Pippin JW, Roberts JM, Shankland SJ. Cyclin I protects podocytes from apoptosis. J Biol Chem 281:28048-57, 2006.
Huber TB, Hartleben B, Kim J et al. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol 23:4917-28, 2003.
Dai C, Yang J, Liu Y. Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice. J Am Soc Nephrol 13:411-22, 2002.
Sharples EJ, Patel N, Brown P, Stewart K, Mota-Philipe H, Sheaff M, Kieswich J, Allen D, Harwood S, Raftery M, Thiemermann C, Yaqoob MM. Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol 15:2115-24, 2004.
Kiley SC, Thornhill BA, Tang SS, Ingelfinger JR, Chevalier RL. Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. Kidney Int 63:33-42, 2003.
Ortega A, Ramila D, Ardura JA, Esteban V, Ruiz-Ortega M, Barat A, Gazapo R, Bosch RJ, Esbrit P. Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity. J Am Soc Nephrol 17:1594-603, 2006.
Alvarez Arroyo MV, Suzuki Y, Yagüe S, Lorz C, Jimenez S, Soto C, Barat A, Belda E, Gonzalez Pacheco FR, Deudero JJP, Castilla MA; Egido J, Ortiz A, Caramelo C. Role of vascular endothelial growth factor in tubular cell protection against acute cyclosporine toxicity. Transplantation 74:1618-1624, 2002.
Bridgewater DJ, Ho J, Sauro V, Matsell DG. Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway. Kidney Int 67:1308-14, 2005.
Logar CM, Brinkkoetter PT, Krofft RD, Pippin JW, Shankland SJ. Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo. Kidney Int 72:489-98, 2007.
Amaravadi R, Thompson CB. The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest 115:2618-24, 2005.
Ortiz A, Lorz C, Catalán MP, Danoff TM, Yamasaki Y, Egido J, Neilson EG. Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure. Kidney Int 57:969-981, 2000.
Lorz C, Ortiz A, Justo P, González-Cuadrado S, Duque N, Gómez-Guerrero C, Egido J. Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli. J Am Soc Nephrol 11:1266-1277, 2000.
Andreucci M, Michael A, Kramers C et al. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int 64:1189-98, 2003.
Miller SB, Martin DR, Kissane J, Hammerman MR. Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat. Proc Natl Acad Sci USA 89:11876-80, 1992.
Vijayan A, Martin DR, Sadow JL, Kissane J, Miller SB. Hepatocyte growth factor inhibits apoptosis after ischemic renal injury in rats. Am J Kidney Dis 38:274-8, 2001.
Imamura R, Isaka Y, Ichimaru N, Takahara S, Okuyama A. Carbamylated erythropoietin protects the kidneys from ischemia-reperfusion injury without stimulating erythropoiesis. Biochem Biophys Res Commun 353:786-92, 2007.
Hirschberg R, Kopple J, Lipsett P, Benjamin E, Minei J, Albertson T, Munger M, Metzler M, Zaloga G, Murray M, Lowry S, Conger J, McKeown W, O'shea M, Baughman R, Wood K, Haupt M, Kaiser R, Simms H, Warnock D, Summer W, Hintz R, Myers B, Haenftling K, Capra W, et al. Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure. Kidney Int 55:2423-32, 1999.
Hladunewich MA, Corrigan G, Derby GC, Ramaswamy D, Kambham N, Scandling JD, Myers BD. A randomized, placebo-controlled trial of IGF-1 for delayed graft function: a human model to study postischemic ARF. Kidney Int 64:593-602, 2003.
www.clinicaltrials.gov/ct/gui/show/NCT00425698, accessed 7 december 2007.
Kindt N, Menzebach A, Van de Wouwer M, Betz I, De Vriese A, Conway EM. Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure. FASEB J [Epub ahead of print], 2007.
Lechler P, Wu X, Bernhardt W, Campean V, Gastiger S, Hackenbeck T, Klanke B, Weidemann A, Warnecke C, Amann K, Engehausen D, Willam C, Eckardt KU, Rödel F, Wiesener MS. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol 171:1483-98, 2007.
Luo JL, Kamata H, Karin M. IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest 115:2625-32, 2005.
Sugiyama H, Savill JS, Kitamura M, Zhao L, Stylianou E. Selective sensitization to tumor necrosis factor-alpha-induced apoptosis by blockade of NF-kappaB in primary glomerular mesangial cells. J Biol Chem 274:19532-7, 1999.
Lorz C, Benito-Martín A, Boucherot A, Ucero AC, Rastaldi MP, Henger A, Armelloni S, Santamaría B, Kretzler M, Egido J, Ortiz A. The death ligand TRAIL in diabetic nephropathy. J Am Soc Nephrol 19;904-14, 2008.
Janes KA, Albeck JG, Gaudet S, et al. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 310:1646-53, 2005.
Sanz AB, Justo P, Sanchez-Niño MD, Blanco-Colio LM, Winkles JA, Kreztler M, Jakubowski A, Egido J, Ruiz-Ortega M, Ortiz A. The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation. J Am Soc Nephrol 19:695-703, 2008.
Justo P, Sanz A, Lorz C, Egido J, Ortiz A. Expression of Smac/Diablo in tubular epithelial cells and during acute renal failure. Kidney Int 64(Suppl.86):52-56, 2003.
Justo P, Sanz AB, Sanchez-Niño MD, Winkles JA, Lorz C, Egido J, Ortiz A. Cytokine cooperation in renal tubular cell injury: the role of TWEAK. Kidney Int 70:1750-8, 2006.
Hamar P, Song E, Kokeny G, Chen A, Ouyang N, Lieberman J. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci USA 101:14883-8, 2004.
Misseri R, Meldrum DR, Dinarello CA, Dagher P, Hile KL, Rink RC, Meldrum KK. TNF-alpha mediates obstruction-induced renal tubular cell apoptosis and proapoptotic signaling. Am J Physiol Renal Physiol 288:F406-11, 2005.
Justo J, Sanz AB, Lorz C, Egido J, Ortiz A. Lethal activity of FADD death domain in renal tubular epithelial cells. Kidney Int 69:2205-2211, 2006.
Bannerman DD, Tupper JC, Kelly JD et al. The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta. J Clin Invest 109:419-25, 2002.
Ling H, Li X, Jha S, Wang W, Karetskaya L, Pratt B, Ledbetter S. Therapeutic role of TGF-beta-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation. J Am Soc Nephrol 14:377-88, 2003.
Bhaskaran M, Reddy K, Radhakrishanan N, Franki N, Ding G, Singhal PC. Angiotensin II induces apoptosis in renal proximal tubular cells. Am J Physiol Renal Physiol 284:F955-65, 2003.
Schiffer M, Bitzer,M, Roberts,IS et al. Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest 108:807-16, 2001.
Durvasula RV, Petermann AT, Hiromura K et al. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int 65:30-9, 2004.
Ding G, Reddy K, Kapasi AA et al. Angiotensin II induces apoptosis in rat glomerular epithelial cells. Am J Physiol Renal Physiol 283:F173-F180, 2002.
Ortiz A, Ziyadeh FN, Neilson EG. Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys. J Invest Med 45:50-56, 1997.
Susztak K, Raff AC, Schiffer M, Böttinger EP. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55:225-33, 2006.
Allen DA, Harwood S, Varagunam M, Raftery MJ, Yaqoob MM. High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases. FASEB J 17:908-10, 2003.
Zheng X, Zhang X, Sun H et al. Protection of renal ischemia injury using combination gene silencing of complement 3 and caspase 3 genes. Transplantation 82:1781-1786, 2006.
Du C, Wang S, Diao H, Guan Q, Zhong R, Jevnikar AM. Increasing resistance of tubular epithelial cells to apoptosis by shRNA therapy ameliorates renal ischemia-reperfusion injury. Am J Transplant 6:2256-2267, 2006.
Kelly KJ, Plotkin Z, Vulgamott SL, Dagher PC. P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. J Am Soc Nephrol 14:128-38, 2003.
Bando Y, Tsukamoto Y, Katayama T, Ozawa K, Kitao Y, Hori O, Stern DM, Yamauchi A, Ogawa S. ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. FASEB J 18:1401-3, 2004.
Daemen MA, Van't Veer C, Denecker G, Heemskerk VH, Wolfs TG, Clauss M, Vandenabeele P, Buurman WA. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 104:541-9, 1999.
Faubel S, Edelstein CL. Caspases as drug targets in ischemic organ injury. Curr Drug Targets Immune Endocr Metabol Disord 5:269-87, 2005.
Wei Q, Yin XM, Wang MH, Dong Z. Bid deficiency ameliorates ischemic renal failure and delays animal death inC57BL/6 mice. Am J Physiol Renal Physiol 290:F35-42, 2006.
Servais H, Ortiz A, Devuyst O, Denamur S, Tulkens PM, Mingeot-Leclercq MP. Renal cell apoptosis induced by nephrotoxic drugs: cellular and 5 molecular mechanisms and potential approaches to modulation. Apoptosis 13:11-32, 2008.
Yang CW, Faulkner GR, Wahba IM, Christianson TA, Bagby GC, Jin DC, Abboud HE, Andoh TF, Bennett WM: Expression of apoptosis-related genes in chronic cyclosporine nephrotoxicity in mice. Am J Transplant 2:391-399, 2002.
Justo P, Lorz C, Sanz A, Egido J, Ortiz A. Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis. J Am Soc Nephrol 14:3072-80, 2003.
Lorz C, Justo P, Sanz A, Subira D, Egido J, Ortiz A. Paracetamol-induced renal tubular injury: a role for ER stress. J Am Soc Nephrol 15:380-9, 2004.
Ortiz A, Lorz C, Catalán MP, Ortiz A, Coca S, Egido J. Cyclosporine A induces apoptosis in murine tubular epithelial cells: role of caspases. Kidney Int Suppl 68:S25-S29, 1998.
Hortelano S, Castilla M, Torres AM, Tejedor A, Bosca L. Potentiation by nitric oxide of cyclosporin A and FK506-induced apoptosis in renal proximal tubule cells. J Am Soc Nephrol 11:2315-2323, 2000.
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J Biol Chem 277:13430-13437, 2002.
Lassus P, Opitz-Araya X, Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 297:1352-4, 2002.
Bonzon C, Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DD. Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol Biol Cell 17:2150-7, 2006.
Ricci JE, Munoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N, Scheffler IE, Ellisman MH, Green DR. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 117:773-786, 2004.
Justo P, Sanz AB, Egido J, Ortiz A. 3,4-di-deoxyglucosone-3-ene induces apoptosis in renal tubular epithelial cells. Diabetes 54:2424-9, 2005.
Hortelano S, Lopez-Collazo E, Bosca L. Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages. Br J Pharmacol 126:1139-1146, 1999.
Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115:2656-64, 2005.
Breckenridge DG, Germain M, Mathai JP, et al. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22:8608-18, 2003.
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103, 2000.
McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol;21:1249-59, 2001.
Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, Nicholson DW. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature;429:75-9, 2004.
Lorz C, Justo P, Sanz AB, Egido J, Ortiz A. Role of Bcl-xL in paracetamol-induced tubular epithelial cell death. Kidney Int 67:592-601, 2005.
Ng FW, Nguyen M, Kwan T, et al. p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. J Cell Biol 139:327-38, 1997.
Tagami S, Eguchi Y, Kinoshita M, et al. A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. Oncogene 19:5736-46, 2000.
Mund T, Gewies A, Schoenfeld N, et al. Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum. FASEB J 17:696-8, 2003.
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, Stevens JL, Ron D. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12:982-95, 1998.
Servais H, Van Der Smissen P, Thirion G, Van der Essen G, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP. Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria. Toxicol Appl Pharmacol 206:321-33, 2005.
Servais H, Jossin Y, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. Antimicrob Agents Chemother 50:1213-21, 2006.
Jaattela M, Cande C, Kroemer G. Lysosomes and mitochondria in the commitment to apoptosis: a potential role for cathepsin D and AIF. Cell Death Differ 11:135-6, 2004.
Seth R, Yang C, Kaushal V, Shah SV, Kaushal GP. p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. J Biol Chem 280:31230-9, 2005.
Jiang M, Wei Q, Wang J, Du Q, Yu J, Zhang L, Dong Z. Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis. Oncogene 25:4056-66, 2006.
Vousden KH, Lane DP. p53 in health and disease. Nat Rev Mol Cell Biol 8:275-83, 2007.
Erster S, Mihara M, Kim RH, Petrenko O, Moll UM. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol;24:6728-41, 2004.
Arany I, Megyesi JK, Kaneto H, Price PM, Safirstein RL. Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells. Am J Physiol Renal Physiol 287:F543-F549, 2004.
Price PM, Yu F, Kaldis P et al. Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2. J Am Soc Nephrol 17:2434-2442, 2006.
Yu F, Megyesi J, Safirstein RL, Price PM. Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo. Am J Physiol Renal Physiol 293:F52-9, 2007.
Sugioka R, Shimizu S, Funatsu T, Tamagawa H, Sawa Y, Kawakami T, Tsujimoto Y. BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo. Oncogene 22:8432-40, 2003.
Ono M, Sawa Y, Ryugo M, Alechine AN, Shimizu S, Sugioka R, Tsujimoto Y, Matsuda H. BH4 peptide derivative from Bcl-xL attenuates ischemia/reperfusion injury thorough anti-apoptotic mechanism in rat hearts. Eur J Cardiothorac Surg 27:117-21, 2005.
Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ, Dunne JC, Dietz GP, Bahr M, McDunn JE, Karl IE, Wagner TH, Cobb JP, Coopersmith CM, Piwnica-Worms D. TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol 176:5471-7, 2006.
Lavrik IN, Golks A, Krammer PH. Caspases: pharmacological manipulation of cell death. J Clin Invest 115:2665-72, 2005.
Launay S, Hermine O, Fontenay M, Kroemer G, Solary E, Garrido C. Vital functions for lethal caspases. Oncogene 24:5137-48, 2005.
Ben Moshe T, Barash H, Kang TB, Kim JC, Kovalenko A, Gross E, Schuchmann M, Abramovitch R, Galun E, Wallach D. Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology 45:1014-24, 2007.
Melnikov VY, Ecder T, Fantuzzi G, Siegmund B, Lucia MS, Dinarello CA, Schrier RW, Edelstein CL. Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. J Clin Invest 107:1145-52, 2001.
Catalan MP, Santamaría B, Reyero A, Egido E, Ortiz A. 3,4-di-deoxyglucosone-3-ene promotes leukocyte apoptosis. Kidney Int 68:1303-11, 2005.
Catalán MP, Esteban J, Subirá D, Egido J, Ortiz A. Inhibition of caspases improves bacterial clearance in experimental peritonitis. Perit Dial Int 23:123-126, 2003.
Catalán MP, Reyero A, Egido J, Ortiz A. Acceleration of neutrophil apoptosis by glucose-containing peritoneal dialysis solutions: role of caspases. J Am Soc Nephrol 12:2442-9, 2001.
Cauwels A, Janssen B, Waeytens A, Cuvelier C, Brouckaert P. Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat Immunol 4:387-93, 2003.
Pockros PJ, Schiff ER, Shiffman ML, McHutchison JG, Gish RG, Afdhal NH, Makhviladze M, Huyghe M, Hecht D, Oltersdorf T, Shapiro DA. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. Hepatology 46:324-9, 2007.
Baskin-Bey ES, Washburn K, Feng S, Oltersdorf T, Shapiro D, Huyghe M, Burgart L, Garrity-Park M, Van Vilsteren FG, Oliver LK, Rosen CB, Gores GJ. Clinical trial of the pan-caspase inhibitor, IDN-6556, in human liver preservation injury. Am J Transplant 7:218-25, 2007.
Vicent MJ, Pérez-Payá E. Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine. J Med Chem 49:3763-5, 2006.
Cihlar T, Ho ES, Lin DC, Mulato AS. Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids 20:641-8, 2001.
Prakash J, Sandovici M, Saluja V, Lacombe M, Schaapveld RQ, De Borst MH, Van Goor H, Henning RH, Proost JH, Moolenaar F, Këri G, Meijer DK, Poelstra K, Kok RJ. Intracellular delivery of the p38 mitogen-activated protein kinase inhibitor SB202190 [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in renal tubular cells: a novel strategy to treat renal fibrosis. J Pharmacol Exp Ther 319:8-19, 2006.
Ortiz A, Justo J, Sanz A, Melero R, Caramelo C, Fernández Guerrero M, Strutz F, Müller G, Barat A, Egido J. Tubular cell apoptosis and cidofovir-induced acute renal failure. Antiviral Therapy 10:185-190, 2005.
Fischer U, Schulze-Osthoff K. Apoptosis-based therapies and drug targets. Cell Death Differ 12(Suppl.1):942-61, 2005.
Ortiz A, Gonzalez-Cuadrado S, Lorz C, Garcia del Moral R, O'Valle F, Egido J. Cytokines and Fas regulate apoptosis in murine renal interstitial fibroblasts. J Am Soc Nephrol 8:1845-1854, 1997.
Otros artículos de Alberto Ortiz

1. Justo P, Sanz AB, Egido J, Ortiz A. 3,4-di-deoxyglucosone-3-ene induces apoptosis in renal tubular epithelial cells. Diabetes 54:2424-9, 2005.
2. Justo P, Sanz AB, Sanchez-Niño MD, Winkles JA, Lorz C, Egido J, Ortiz A. Cytokine cooperation in renal tubular cell injury: the role of TWEAK. Kidney Int 70:1750-8, 2006.
3. Marrón B, Remón C, Pérez-Fontán M, Quirós P, Ortíz A. Benefits of preserving residual renal function in peritoneal dialysis. Kidney Int 73:S42-S51, 2008.
4. Lorz C, Benito-Martín A, Boucherot A, Ucero AC, Rastaldi MP, Henger A, Armelloni S, Santamaría B, Kretzler M, Egido J, Ortiz A. The death ligand TRAIL in diabetic nephropathy. J Am Soc Nephrol 19:904-14, 2008.
5. Sanz AB, Justo P, Sanchez-Niño MD, Blanco-Colio LM, Winkles JA, Kreztler M, Jakubowski A, Egido J, Ruiz-Ortega M, Ortiz A. The cytokine TWEAK modulates renal tubulointerstitial inflammation. J Am Soc Nephrol 19:695-703, 2008.
6. Ortiz A, Oliveira JP, Waldek S, Warnock DG, Cianciaruso B, Wanner C, on behalf of the Fabry Registry Nephropathy in males and females with Fabry disease: Cross-sectional description of patients before treatment with enzyme replacement therapy Nephrol Dial Transplant 23:1600-7, 2008.
7. Ortiz A, Oliveira JP, Wanner C, Brenner B, Waldek S, Warnock D. Diagnosis and treatment of Fabry nephropathy, with clinical practice recommendations and guidelines. Nature Clinical Practice Nephrology 4:327-36, 2008.
8. Moreno JA, Sanchez-Niño MD, Sanz AB, Lassila M, Holthofer H, Blanco-Colio LM, Egido J, Ruiz-Ortega M, Ortiz A. A slit in podocyte death. Current Medicinal Chemistry 15:1645-54, 2008.
9. Sanchez-Niño MD, Sanz AB, Ihalmo P, Lassila M, Holthofer H, Mezzano S, Aros C, Groop PH, Saleem MA, Mathieson PW, Langham R, Kretzler M, Nair V, Lemley KV, Nelson RG, Mervaala E, Mattinzoli D, Rastaldi MP, Ruiz-Ortega M, Martin-Ventura JL, Egido J, Ortiz A. The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol [Epub ahead of print], 2008.
10. Carrero JJ, Ortiz A, Qureshi AR, Martín-Ventura JL, Bárány P, Heimbürger O, Marrón B, Metry G, Snaedal S, Lindholm B, Egido J, Stenvinkel P, Blanco-Colio LM. Additive effects of soluble TWEAK and inflammation on mortality in patients undergoing hemodialysis. Clin J Am Soc Nephrol 4:110-8, 2009.

Para comunicarse con Alberto Ortiz mencionar a SIIC como referencia:
aortiz@fjd.es

Autor invitado
6 de enero, 2009
Descripción aprobada
26 de febrero, 2009
Reedición siicsalud
7 de junio, 2021

Acerca del trabajo completo
MUERTE CELULAR POR APOPTOSIS EN ENFERMEDAD RENAL

Título original en castellano
MECANISMOS DE LA APOPTOSIS RENAL EN LA SALUD Y EN LA ENFERMEDAD

Autor
Alberto Ortiz1
1 Medico, Fundacion Jimenez Diaz, Universidad Autonoma Madrid, Madrid, España, Jefe Asociado/profesor Asociado

Acceso a la fuente original
Journal of the American Society of Nephrology
http://www.JASN.org

El artículo se relaciona estrictamente con las especialidades de siicsalud
El artículo se conecta secundariamente con las especialidades
      


ua40317