Juan Gilabert-Estellés *

Autor invitado por SIIC

EXPRESIÓN DE MICRORNAS IMPLICADOS EN LA ANGIOGÉNESIS EN CÁNCER ENDOMETRIAL.

La diferente expresión de los micro ARN observada en el tejido tumoral podría modular los niveles de factores angiogénicos y desempeñar un papel importante en la patogenia del cáncer endometrial.

*Juan Gilabert-Estellés
describe para SIIC los aspectos relevantes de su trabajo
MICRORNAS RELATED TO ANGIOGENESIS ARE DYSREGULATED IN ENDOMETRIOID ENDOMETRIAL CANCER
Institución principal de la investigación
*Consorcio Hospital General Universitario de Valencia, Valencia, España
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Referencias bibliográficas
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2. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics. CA Cancer J Clin 60:277-300, 2010.
3. Kamat AA, Merritt WM, Coffey D, Lin YG, Patel PR, Broaddus R, Nugent E, Han LY, Landen CN Jr, Spannuth WA et al. Clinical and biological significance of vascular endothelial growth factor in endometrial cancer. Clin Cancer Res 13:7487-7495, 2007.
4. Klauber N, Rohan RM, Flynn E, D'Amato RJ. Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470. Nat Med 3:443-446, 1997.
5. Carmeliet P. Angiogenesis in health and disease. Nat Med 9:653-660, 2003.
6. Tan XJ, Lang JH, Liu DY, Shen K, Leng JH, Zhu L. Expression of vascular endothelial growth factor and thrombospondin-1 ARNm in patients with endometriosis. Fertil Steril 78:148-153, 2002.
7. Stefansson IM, Salvesen HB, Akslen LA. Cancer Res 66:3303-3309, 2006.
8. Wu W, Sun M, Zou GM, Chen J. MicroRNA and cancer: Current status and prospective. Int J Cancer 120:953-960, 2007.
9. Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, Mercatanti A, Hammond S, Rainaldi G. MicroRNAs modulate the angiogenic properties of HUVECs. Blood 108:3068-3071, 2006.
10. Zorio E, Medina P, Rueda J, Millán JM, Arnau MA, Beneyto M, Marín F, Gimeno JR, Osca J, Salvador A, España F, Estellés A. Insights of the role of microRNAs in cardiac diseases: from biological signaling to therapeutic targets Cardiovas & Hematol Agent in Medicinal Chemistry 7:82-90, 2009.
11. Gilabert Estelles J, Braza Boils A, Ramon LA, Zorio E, Medina P, Espana F, Estelles A. Role of microRNAs in gynecological pathology. Curr Med Chem 19:2406-2413, 2012.
12. Boren T, Xiong Y, Hakam A, Wenham R, Apte S, Wei Z, Kamath S, Chen DT, Dressman H, Lancaster JM. MicroRNAs and their target messenger RNAs associated with endometrial carcinogenesis. Gynecol Oncol 110:206-215, 2008.
13. Chung TK, Cheung TH, Huen NY, Wong KW, Lo KW, Yim SF, Siu NS, Wong YM, Tsang PT, Pang MW et al. Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women. Int J Cancer 124:1358-1365, 2009.
14. Cohn DE, Fabbri M, Valeri N, Alder H, Ivanov I, Liu CG, Croce CM, Resnick KE. Comprehensive miRNA profiling of surgically staged endometrial cancer. Am J Obstet Gynecol 202:656, 2010. e1-656.e8.
15. Ratner ES, Tuck D, Richter C, Nallur S, Patel RM, Schultz V, Hui P, Schwartz PE, Rutherford TJ, Weidhaas JB. MicroRNA signatures differentiate uterine cancer tumor subtypes. Gynecol Oncol 118:251-257, 2010.
16. Wang S, Olson EN. AngiomiRs-key regulators of angiogenesis. Curr Opin Genet Dev 19:205-211, 2009.
17. Caporali A, Emanueli C. MicroRNA regulation in angiogenesis. Vascul Pharmacol 55:79-86, 2011.

Otros artículos de Juan Gilabert-Estellés

Braza-Boïls A, Salloum-Asfar S, Marí-Alexandre J, Arroyo AB, González-Conejero R, Barceló-Molina M, García-Oms J, Vicente V, Estellés A, Gilabert-Estellés J, Martínez C. Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis. Hum Reprod 30:2292-302, 2015.
Marí-Alexandre J, García-Oms J, Barceló-Molina M, Gilabert-Aguilar J, Estellés A, Braza Boíls A, Gilabert-Estellés J. MicroRNAs and angiogenesis in endometriosis. Thromb Res 135(Suppl 1):S38-40, 2015.
Braza-Boïls A, Marí-Alexandre J, Gilabert J, Sánchez-Izquierdo D, España F, Estellés A, Gilabert-Estellés J. MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors. Hum Reprod 29:978-88, 2014.
Braza-Boïls A, Gilabert-Estellés J, Ramón LA, Gilabert J, Marí-Alexandre J, Chirivella M, España F, Estellés A. Peritoneal fluid reduces angiogenesis-related microRNA expression in cell cultures of endometrial and endometriotic tissues from women with endometriosis. PLoS One 8:e62370, 2013.
Ramón LA, Braza-Boïls A, Gilabert J, Chirivella M, España F, Estellés A, Gilabert-Estellés J. MicroRNAs related to angiogenesis are dysregulated in endometrioid endometrial cancer. Hum Reprod 27:3036-45, 2012.
Gilabert-Estelles J, Braza-Boils A, Ramon LA, Zorio E, Medina P, Espana F, Estelles A. Role of microRNAs in gynecological pathology. Curr Med Chem 19:2406-13, 2012.
Gilabert-Estellés J, Ramón LA, Braza-Boïls A, Gilabert J, Chirivella M, España F, Estellés A. Plasminogen activator inhibitor-1 (PAI-1) 4 G/5 G polymorphism and endometrial cancer. Influence of PAI-1 polymorphism on tissue PAI-1 antigen and ARNm expression and tumor severity. Thromb Res 130:242-7, 2012.
Ramón LA, Braza-Boïls A, Gilabert-Estellés J, Gilabert J, España F, Chirivella M, Estellés A. microRNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod 26:1082-90, 2011.
Gilabert-Estelles J, Zorio E, Castello JM, Estelles A, Gilabert-Aguilar J. Laparoscopic approach to right diaphragmatic endometriosis with argon laser: case report. J Minim Invasive Gynecol 17:124-7, 2010.
Downes E, Sikirica V, Gilabert-Estelles J, Bolge SC, Dodd SL, Maroulis C, Subramanian D. The burden of uterine fibroids in five European countries. Eur J Obstet Gynecol Reprod Biol 152:96-102, 2010.

Para comunicarse con Juan Gilabert-Estellés mencionar a SIIC como referencia:
juangilaeste@yahoo.es

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Acerca del trabajo completo

EXPRESIÓN DE MICRORNAS IMPLICADOS EN LA ANGIOGÉNESIS EN CÁNCER ENDOMETRIAL.

Título original en castellano
MICRORNAS RELACIONADOS CON LA ANGIOGENESIS ESTAN DISREGULADOS EN CANCER ENDOMETRIAL ENDOMETRIODE

Autor
Juan Gilabert-Estellés¹, Luis A Ramón², Aitana Braza-Boïls³, Juan Gilabert⁴, Amparo Estellés⁵
1 Doctor en Medicina y Cirugía, Consorcio Hospital General Universitario de Valencia, Valencia, España, Jefe de Área Materno-infantil
2 Doctor en Biología
3 Doctora en Biología
4 Doctor en Medicina y Cirugía
5 Doctora en Medicina

Acceso a la fuente original
Human Reproduction
https://academic.oup.com/humrep/issue

El artículo se relaciona estrictamente con las especialidades de siicsalud
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