Francisco José Tinahones *

Autor invitado por SIIC

El trabajo contribuye a establecer la ligazón genética entre dos fenotipos clínicos (hiperuricemia e hipertrigliceridemia) frecuentemente asociados

CLUSTER DE LAS APOLIPOPROTEINAS AI-CIII-AIV Y RELACIÓN HIPERURICEMIA-HIPERTRIGLICERIDEMIA

La alta prevalencia de mutaciones en el cluster de las apolipoproteinas AI-CIII-AIV en pacientes gotosos, contribuye a explicar al fenotipo lipoproteico que presentan estos pacientes, y esta contribución es conjunta, influyendo más los sitios polimorficos del gen de la apolipoproteína AI que el del gen de la apolipoproteína CIII.

*Francisco José Tinahones
describe para SIIC los aspectos relevantes de su trabajo
CONTRIBUTION OF POLYMORPHISMS IN THE APOLIPOPROTEIN AL-CIII-AIV CLUSTER TO HYPERLIPIDAEMIA IN PATIENTS WITH GOUT
Institución principal de la investigación
*Hospitla Regional Universitario Carlos Haya, Málaga, España, Málaga, España
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Referencias bibliográficas
1. MM Gertler, SM Garn and SA Levine, Serum uric acid in relation to age and physique in health and coronary heart disease. Ann Intern Med. 34 (1951), pp. 1421-1431.2. C Iribarren, DS Sharp, JD Curb and K Yano, High uric acid: A metabolic marker of coronary heart disease among alcohol abstainers. J Clin Epidemiol. 49 (1996), pp. 673-678.3. W Rathmann, H Hauner, K Dannehl and FA Gries, Association of elevated uric acid with coronary heart disease in diabetes mellitus. Diabete Metab. 19 (1993), pp. 159-166.4. H Vuorinen-Markkola and H Yki-Järvinen, Hyperuricemia and Insulin Resistance. J Clin Endocrinol Metab. 78 (1994), pp. 25-29.5. F Facchini, Y-D Ida Chen, CB Hollenbeck and GM Reaven, Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA. 266 (1991), pp. 3008-3011.6. AQ Galvan, A Natali, S Baldi, S Frascerra, G Sanna, D Ciociaro and E Ferrannini, Effect of insulin on uric acid excretion in humans. Am J Physiol. 268 (1995), pp. E1-E5.7. GM Reaven, H Lithell and L Landsberg, Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system. N Engl J Med. 334 (1996), pp. 374-381.8. Tinahones FJ, Collantes E, Perez Lindón G, C-Soriguer FJ, Lillo JA, Sánchez Guijo P. Decreased triglyceride levels with low-calorie diet and increased renal excretion of uric acid in hyperuricemic-hyperlipidemic patients. An Rheum Dis 1995; 54:609-610.9. Tinahones FJ, Collantes E, Gonzalez A, C-Soriguer F, Añón J and Sánchez P. Increased VLDL levels and disminished renal excretion of uric acid in hyperuricemic-hypertrigliceridemic patients.Br J Rheumatol 1995; 34:920-924.10. Tinahones FJ, Pérez-Lindón G, Soriguer FJ, Pareja A, Sánchez-Guijo P, Collantes E. Dietary alterations of plasma VLDL levels modify renal excretion of urates in hyperuricemic-hypertriglyceridemic patients. J Clin Endocrinol Metabolism 1997; 82:1188-1191.11. Martine Groenendijk, Rita M. Cantor, Tjerk W. A. De Bruin, and Geesje M. Dallinga-Thie. New genetic variants in the apoA-I and apoC-III genes and familial combined hyperlipidemia J. Lipid Res. 2001 42:188-194.12. Dawn M. Waterworth, Josep Ribalta, Viviane Nicaud, Jean Dallongeville, Steve E. Humphries, and Philippa Talmud ApoCIII gene variants modulate postprandial response to both glucose and fat tolerance Tests Circulation 99 (14):1872-1877.13. Ferns GAA, Ritchie C, Stocks J, Galton DJ Genetic polymorphisms of apolipoprotein C-III and insulin in survivors of myocardial infarction. Lancet 1985; 2:300-303.14. Ordovás JM, Civeira F, Genest JJ, Robbins AH, Meade T, Pocovi M et al Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III and A-IV gene locus: relationships with lipids, apolipoproteins and premature coronary artery disease. Atherosclerosis 1991; 87:75-86.15. Xu CF, Angelico F, Del Ben M, Humphries SE Role of genetic variation at the apo AI-CIII-AIV gene cluster in determining plasma apo A-I levels in boys and girls. Genet Epidemiol 1993; 10:113-122.16. Barre DE, Guerra R, Verstraete R, Wang Z, Grundy SM, Cohen JC Genetic analysis of a polymorphism in the human apolipoprotein A-I gene promoter: effect on plasma HDL-cholesterol levels. J Lipid Res 1994; 35:1292-1296.17. Civeira F, Pocovi M, Cenarro A, Garcés C, Ordovás JM Adenine for guanine substitution. 78 base pairs to the apolipoprotein (apo) A-I gene: relation with high density lipoprotein cholesterol and apo A-I concentrations. Clin Genet 1993; 44:307-312.18. Soriguer-Escofet F, Esteva I, Rojo-Martinez G, Ruiz de Adana S, Catala M, Merelo MJ, Aguilar M, Tinahones F, Garcia-Almeida JM, Gomez-Zumaquero JM, Cuesta-Munoz AL, Ortego J, Freire JM; Diabets Group of the Andalusian Society of Endocrinology and Nutrtion. Prevalence of latent autoimmune diabetes of adults (LADA) in Southern Spain. Diabetes Res Clin Pract. 2002 Jun;56(3):213-20.19. Shoulders CC, Narcisi TM, Jarmuz A, Brett DJ, Bayliss JD, Scott J. Characterization of genetic markers in the 5'flanking region of the apo A1 gene. Hum Genet. 1993 Mar; 91(2):197-8.20. Jeenah M, Kessling A, Miller N, Humphries S. G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations. Mol Biol Med. 1990 Jun;7(3):233-41.21. Dammerman M, Sandkuijl LA, Halaas JL, Chung W, Breslow JL. An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3-UTR polymorphisms. Proc Natl Acad Sci USA 1993; 90:4562–6.

Otros artículos de Francisco José Tinahones

Cardona F, Tinahones FJ, Collantes E, Escudero E, García-Fuentes E, Soriguer FJ. Contribution of polymorphisms in the apoliporotein AI-CIII-AIV cluster hyperlipidaemia in patients with gout. Ann Rheum Dis. 2005 Jan; 64(1):85-8.Tinahones FJ, Gómez-Zumaquero JM, Garrido Lourdes, Cardona F, Rojo G, Esteva I, Ruiz de Adana MS, Soriguer FJ. Influence of age and sex on levels of anti-oxidized LDL antibodies and immune complexes in the general population. J Lipid Res. 2005 Mar; 46(3):452-7.Cardona F, Morcillo S, Gonzalo-Marin M, Tinahones F. The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndromE. J Clin Endocrinol Metab. 2005 Feb 15; [Epub ahead of print].Soriguer F, Esteva I, Rojo-Martinez G, Ruiz De Adana MS, Dobarganes MC, Garcia-Almeida JM, Tinahones F, Beltran M, Gonzalez-Romero S, Olveira G, Gomez-Zumaquero JM. Oleic acid from cooking oils is associated with lower insulin resistance in the general population (Pizarra study). Eur J Endocrinol. 2004 Jan; 150(1):33-9.Soriguer FJ, Rojo G, Esteva I, Ruiz de Adana MS, Catala M, Merelo MJ, Beltran M, Tinahones FJ. Prevalence ofobesity in south-east Spain and its relation with social and health factors. Eur J Epidemiol 2004; 19:33-40.Gómez JM, Tinahones FJ, De Ramón E, Camps M, Garrido L, Soriguer F. Association of biological markers of activity of systemic lupus erythematosus with levels of anti-oxidized low density lipoprotein antibodies. Rheumatology 2004; 43:510-3.Rojo G, Esteva I, Ruiz de Adana S, Catala M, Merelo MJ, Tinahones FJ, Gómez-Zumaquero JM, Cuesta AL, Cardona F, Soriguer F. Paterns of insulin resistance in the general population of southeast Spain. Diabetes Res Clin Pract 2004; 65:247-256.Tinahones FJ, Monzón A, C-Soriguer FJ et al. Dietary palmitic acid influence LDL-mediated lymphocity proliferation differently to other mano-and polyunsaturated fatty acids in rats Diabet Nutr Metab 2004; 17:250-258.Soriguer F, Moreno F, Rojo-Martinez G, Cardona F, Tinahones F, Gomez-Zumaquero JM, Garcia-Fuentes E, Morcillo S. Redistribution of abdominal fat after a period of food restriction in rats is related to the type of dietary fat. Br J Nutr. 2003 Jan; 89(1):115-22. Cardona F, Tinahones FJ, Collantes E, Escudero A, Garcia-Fuentes E, Soriguer FJ. The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates. Rheumatology (Oxford). 2003 Mar; 42(3):468-72.

Para comunicarse con Francisco José Tinahones mencionar a SIIC como referencia:
fernando.cardona.exts@juntadea

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Acerca del trabajo completo

CLUSTER DE LAS APOLIPOPROTEINAS AI-CIII-AIV Y RELACIÓN HIPERURICEMIA-HIPERTRIGLICERIDEMIA

Título original en castellano
Contribucion de los polimorfismos en el cluster de las apolipoproteinas AI-CIII-AIV a la hiperlipemia de pacientes gotosos

Autor
Francisco José Tinahones¹, Fernando Cardona²
1 Médico, Hospital Regional Universitario Carlos Haya, Facultativo Especialista de Area
2 Biólogo, Hospital Regional Universitario Carlos Haya, Investigador

Acceso a la fuente original
Annals of the Rheumatic Diseases
http://ard.bmjjournals.com/