ALTA ACURÁCIA NA DETECÇÃO DE MICROMETÁSTASES DE CARCINOMA DE MAMA EM LINFONODO SENTINELA

Kenia Melissa Borghetti*
Autora invitada por SIIC

Protocolo de avaliação anatomopatológica do linfonodo sentinela que inclue cortes semiseriados

A análise histológica do linfonodo sentinela através de um protocolo de cortes semi-seriados em dois níveis corados pelo HE e pela técnica da IHC utilizando anticorpos anticitoqueratina apresenta alta acurácia em predizer o status linfonodal em câncer de mama. A aplicação desta metodologia aumenta a taxa de detecção de micrometástases em relação a análise histológica de rotina de todos linfonodos axilares.

*Kenia Melissa Borghetti
describe para SIIC los aspectos relevantes de su trabajo
ALTA ACURÁCIA NA DETECÇÃO DE MICROMETÁSTASES DE CARCINOMA DE MAMA EM LINFONODO SENTINELA,

Revista da Sociedade Brasileira de Cancerologia,
7(28):105-113

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Programa de Post Graduados en Patología Gral. y Experimental de la Fundación de la Facultad Federal de Ciencias Médicas de Porto Alegre, Porto Alegre, Brasil

Profundizar

Referencias bibliográficas

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2. Dowlatshahi K, Fan M, Bloom KJ et al. Occult metastases in the sentinel lymph nodes of patients with early stage breast carcinoma. A preliminary study. Cancer 86(6):990-996, sep. 1999.
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5. Canavese G, Gipponi M, Catturich A et al. Technical issues and pathologic implications of sentinel lymph node biopsy in early-stage breast cancer patients. Journal of Surgical Oncology 77:81-87, 2001.
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7. Mcintosh SA, Going JJ, Soukop M et al. Therapeutic implications of sentinel lymph node in breast cancer. The Lancet 354:570, ago 1999.
8. Liu LH, Siziopikou KP, Gabram S et al. Evaluation of axillary sentinel lymph node biopsy by immunohistochemistry and multilevel sectioning in patients with breast carcinoma. Archives of Pathology & Laboratory Medicine 124:1670-1673, nov 2000.
9. Sabel MS, Zhang P, Barnwell JM et al. Accuracy of sentinel node biopsy in predicting nodal status in patients with breast carcinoma. Journal of Surgery Oncology 77(4):243-246, 2001.
10. Weerts JM, Maweja S, Tamigneaux I et al. The sentinel lymph node biopsy in breast cancer. Acta Chir Belg 102(2):110-113, 2002.
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12. Mann GB, Buchanan M, Collins JP et al. High incidence of micrometastases in breast cancer sentinel nodes. Australian New Zealand Journal of Surgery 70(11):786-790, nov. 2000.
13. Motomura K, Komoike Y, Inaji H et al. Multiple sectioning and immunohistochemical staining of sentinel nodes in patients with breast cancer. British Journal of Surgery 89:1032-1034, 2002.
14. Torrenga H, Rahusen FD, Meijer S et al. Sentinel node investigation in breast cancer: detailed analysis of the yield from step sectioning and immunohistochemistry. Journal of Clinical Pathology 54:550-552, 2001.
15. Singletary E, Allred C, Ashley P et al. Revision of the American Joint Committee on Cancer staging system for breast cancer. Journal of Clinical Oncology 20(17):3628-3636, sep 2002.
16. College of American Pathologists Consensus Statement 1999. Prognostic factors in breast cancer. Archives of Pathology & Laboratory Medicine 124(7):966-978, jul. 2000.
17. Treseler PA, Tauchi PS. Pathologic analysis of sentinel lymph node. Surgical Clinics of North America 80(6):1695-719, dec. 2000.
18. Weaver DL, Krag DN, Ashikaga T et al. Pathologic analysis of sentinel and nonsentinel lymph nodes in breast carcinoma. A multicenter study. Cancer 88(5):1099-1107, mar. 2000.
19. Mokbel K, Kirkpatrick KL. Recent advances in breast cancer. Curr Med Res Opin 18(1):26-29, 2002.
20. Cserni G, Amendoeira I, Apostolikas N et.al. Discrepancies in current practice of pathological evaluation of sentinel lymph nodes in breast cancer. Results of a questionnaire based survey by the European Working Group for Breast Screening Pathology. J. Clin. Pathol. 2004; 57(7):695-701.

Otros artículos de Kenia Melissa Borghetti

Borghetti KM, Caleffi M. O Fim de um mito: Gravidez após cancer de mama- Revista Brasileira de Mastologia, 1999, 9(4):167-172.

Caleffi, M, Borghetti KM, Gravidez após câncer de mama. In: Santos Jr LA. A mama no ciclo gravídico-puerperal. São Paulo, Editora Atheneu, 2000.

Borghetti KM, Barbosa F, Caleffi M. Biópsia do linfonodo sentinela: uma alternativa para a linfadenectomia? Revista Brasileira de Mastologia 2000, 10(3);148-155.

Caleffi M, Borghetti KM, Duarte Filho D. Dificuldades na avaliação da resposta ao tratamento quimioterápico neoadjuvante. A ressonância magnética é uma alternativa? Revista Pesquisa Médica. FFFCMPA, 2000, 34(1):64.

Caleffi M, Borghetti KM, Antoniazzi R, Graudenz M, Duarte Filho D. Preliminary report of ultrasound-guided cryoablation of breast tumors using a 2.4 mm probe. Breast Cancer Research and Treatment. 23rd Annual San Antonio Breast Cancer Symposium 2000, 64(1):103.

Caleffi M, Luzzato R, Muller APC, Borghetti KM. Fibroadenopapiloma. Mastologia News, Edição Especial XII Congresso Brasileiro de Mastologia e I Congresso de Onco-Mastologia, 2001, 3:35.

Caleffi M, Borghetti KM, Doncatto L, Muller APWC, Duarte RA, Saffer PL. Incidência de recidiva locorregional de câncer de mama após mastectomia e reconstrução mamária imediata com retalho miocutâneo (TRAM). Mastologia News - Edição Especial XII Congresso Brasileiro de Mastologia e I Congresso de Onco-Mastologia, 2001, 3:49.

Duarte Filho D, Graudenz MS, Luzzatto R, Caleffi M, Borghetti K, Dirbas FM, Nowels KW. Pilot study of a novel 10-gauge cryo-based rotational core biopsy system. Breast Cancer Research and Treatment, 24 th Annual San Antonio Breast Cancer Symposium, 2001, 69(3):222.

Caleffi M, Duarte Filho D, Borghetti K, Littrup PJ, White MT, Bouwman D, Freeman-Gibb LA, Zannis VJ, Schultz MJ. Ultrasound-guided cryoablation of breast fibroadenomas at four institutions using a 2.4 mm probe: 6-12 month follow-up. Breast Cancer Research and Treatment, 24th Annual San Antonio Breast Cancer Symposium, 2001, 69(3):228.

Caleffi M, Borghetti KM, Eschiletti J, Antoniazzi R, Duarte Filho D, Luzzato R, Graudenz MS. Misleading residual breast lesions secondary to cryosurgery: results at two years follow-up. Breast Cancer Research and Treatment, 25th Annual San Antonio Breast Cancer Symposium 2002, 76, Suppl 1:S94.

Autora invitada
18 de mayo, 2005

Descripción aprobada
3 de octubre, 2005

Reedición siicsalud
24 de noviembre, 2009

Acerca del trabajo completo

ALTA ACURÁCIA NA DETECÇÃO DE MICROMETÁSTASES DE CARCINOMA DE MAMA EM LINFONODO SENTINELA

Título original en castellano
UM PROTOCOLO ANATOMO-PATOLÓGICO DE ALTA ACURÁCIA NA DETECÇÃO DE MICROMETÁSTASES DE CARCINOMA DE MAMA EM LINFONODO SENTINELA

Autor
Kenia Melissa Borghetti¹

1 Médica, Fundação Faculdade Federal de Ciências Médicas de Porto Alegre, Mestre em Patologia Experimental

Acceso a la fuente original
Revista da Sociedade Brasileira de Cancerologia

http://www.rsbcancer.com.br

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