Recepción del artículo: 13 de Noviembre, 2002

Aprobación: 7 de Enero, 2003

Primera edición: 22 de Enero, 2003

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Especialidades
Principal: Genética Humana
Relacionadas: Medicina Interna,  Infectología,  Inmunología,  Neumonología,  Epidemiología

Enviar correspondencia a:
Joanna Floros PhD, Department of Cellular and Molecular Physiology, H166 The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA

Patrocinio y reconocimiento
Agradezco a la Sra. Sue Myers por el tipeo del manuscrito. Subvención R37 HL34788 de los National Institutes of Health.

COULD SURFACTANT PROTEIN GENETIC VARIANTS DETERMINE SUSCEPTIBILITY TO MYCOBACTERIUM TUBERCULOSIS INFECTION?

Abstract
The growing global incidence of tuberculosis has raised considerable concerns as well as questions as to how to reverse, halt, or minimize this trend. The fact that not all individuals at risk develop active tuberculosis raises important questions regarding variability among individuals in disease susceptibility, underlying mechanisms, specific therapies, and points of intervention. To gain insight into these issues, we studied the hypothesis that surfactant protein (SP) genetic variants can serve as markers to identify disease subgroups with different susceptibilities. The rationale for focusing on these molecules is twofold. First, these molecules are involved in the innate lung host defense (first line of defense) and/or the normal lung function. Thus, their functional capabilities are relevant to the issue at hand. Second, these molecules are identified with natural genetic variability that can serve as "tag" to facilitate identification of subgroups of individuals with different susceptibilities. Three groups of subjects, tuberculosis positive and two controls (tuberculin-skin test positive, and healthy randomly picked subjects) were genotyped for the SP marker alleles. Regression analyses identified SP genetic variants or alleles that associate with increased or decreased risk (susceptibility), suggesting that the SP genetic variants are useful markers in the study of tuberculosis.

Key words
Association study, genotype, innate immunity, surfactant protein

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