Vaccine-derived poliovirus in the environment

Abstract
The live, oral polio vaccine (OPV) has greatly contributed to polio eradication. Nevertheless, the OPV has been known to become virulent; however, the risk of outbreak from the vaccine-derived poliovirus (VDPV) under high herd immunity has been continuously ignored. Results of viral surveillance of river and sewage water in Japan demonstrated virulent VDPV might be temporarily found in nature. A hygiene program, inactive poliovirus vaccine (IPV) immunization, quality surveillance, and a well-maintained herd immunity might play a key role in preventing VDPV outbreaks during the final stages of polio eradication when OPV immunization is terminated.

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Bibliografía del artículo

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