LYMPHOCYTIC CHORIOMENINGITIS VIRUS: ZOONOTIC HUMAN TERATOGEN

Abstract
Lymphocytic choriomeningitis virus (LCMV) is a human zoonosis caused by a rodent-borne arenavirus. It has been associated with both postnatal, as well as in-utero, infection in man. Human infection is acquired after inhalation, ingestion or direct contact with the virus found in the urine, feces and saliva of infected mice, guinea pigs, and hamsters. Congenital LCMV infection should be a diagnostic consideration for infants and children who have chorioretinitis, microcephaly or macrocephaly, hydrocephalus, intracranial calcifications, or nonimmune hydrops fetalis. The diagnosis is made serologically via commercially available immunofluorescent antibody testing. Differentiation of congenital LCMV infection from congenital toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, enterovirus, human parvovirus B19 and syphilis should be made. Further research is necessary to determine the prevalence of this infection in human and rodent populations and to prospectively delineate the spectrum of congenital infection and its consequences. The medical profession, as well as veterinarians and pet shop owners, must educate the public regarding the hazard that wild, pet and laboratory rodents pose to pregnant women.

Key words
Coriomeningitis linfocitaria, virus, teratógeno, zoonosis, infección congénita, coriorretinitis, diagnóstico diferencial, transmisión vertical, transmisión madre-hijo

Bibliografía del artículo

1. Jahrling PB, Peters CJ. Lymphocytic choriomeningitis virus: a neglected pathogenesis of man. Arch Pathol Lab Med 1992; 116:486-8.
2. Komrower GM, Williams BL, Stone PB. Lymphocytic Choriomeningitis in the newborn: probable transplacental infection. Lancet 1955; 1:697-8.
3. Barton LL, Mets MB. Congenital lymphocytic choriomeningitis virus infection: decade of rediscovery. Clin Infect Dis 2001; 33:370-4
4. Peters CJ. Personal communication.
5. Meyer HM Jr, Johnson RT, Crawford IP, Dascomb HE, Rogers NG. Central nervous system syndromes of "viral" etiology: a study of 713 cases. Am J Med 1960; 29:334-47.
6. Tindall GT, Gladstone LA. Hydrocephalus as a sequel to lymphocytic choriomeningitis. Neurology 1957; 7:516-8.
7. Lewis JM, Utz JP. Orchitis, parotitis and meningoencephalitis due to lymphocytic choriomeningitis virus. N Engl J Med 1961; 265:776-80.
8. Barton LL, Budd SC, Morfitt WS, et al. Congenital lymphocytic choriomeningitis virus infection in twins. Pediatr Infect Dis J 1993; 12:528-31.
9. Mets MB, Barton LL, Khan AS, Ksiazek TG. Lymphocytic choriomeningitis virus: an underdiagnosed cause of congenital chorioretinitis. Am J Ophthalmol 2000; 130:209-15.
10. Larsen PD, Chartrand SA, Tomashek KY, Hauser LG, Ksiazek TG. Hydrocephalus complicating lymphocytic choriomeningitis virus in fection. Pediatr Infect Dis J 1993; 12:528-31.
11. Sheinbergas MM, Pmashekas RS, Pikelite RL, et al. Clinical and pathomorphological data on hydrocephalus caused by prenatal infection with lymphocytic choriomeningitis virus. Zh Nevropatol Psikhiatr 1977; 77:1004-7.
12. Lewis VJ, Walter PD, Thacker WL, Winkler WG. Comparison of three tests for the serological diagnosis of lymphocytic choriomeningitis virus infection. J Clin Microbiol 1975; 2:193-7.
13. Lehmann-Grube F, Kallay M, Ibscher B, Schwartz R. Serologic diagnosis of human infections with lymphocytic choriomeningitis virus: comparative evaluation of seven methods. J Med Virol 1979; 4:125-36.
14. Gessner A, Lother H. Homologous interference of lymphocytic choriomeningitis virus involves a ribavarin-susceptible block in virus replication. J Virol 1989; 63:1827-32.

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