Recepción del artículo: 3 de Mayo, 2004

Aprobación: 15 de Septiembre, 2004

Primera edición: 4 de Noviembre, 2004

Palabras clave

Clasificación en siicsalud
Artículos originales> Expertos de Iberoamérica>
página www.siicsalud.com/des/des040/04n02005.htm

Especialidades
Principal: Inmunología
Relacionadas: Hematología,  Gastroenterología,  Epidemiología,  Infectología

Enviar correspondencia a:
de Mattos, Luiz Carlos,

Patrocinio y reconocimiento
Agradecimentos: O autor agradece o apoio recebido da Faculdade de Medicina de São José do Rio Preto (FAMERP) e da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - BEX 1542-03-6).

THE ABO, LEWIS BLOOD GROUPS, SECRETOR STATUS, AND HELICOBACTER PYLORI INFECTION

Abstract
The ABO and Lewis blood groups and the secretor status have been available, either in isolation or jointly, as markers for Helicobacter pylori infection susceptibility or infection by some related diseases. Results from analysis involving apparently normal individuals and patients suffering from varying gastroduodenal diseases, as well as experimental data, are contradictory. If on one hand there are demonstrations that reinforce the importance of ABH-Lewis antigens in the adherence of H. pylori to the gastric mucous membrane of O blood group individuals, on the other hand, not all epidemiological studies support these premises and thus, divergences between clinical and laboratory data remain. As the ABH-Lewis antigens of the gastroduodenal tract present a polymorphic profile which can be discriminated from those observed in red blood cells, it seems sensible that other aspects related to the expression of these glycoconjugates should be assessed. This will give greater support to the interpretation of the results in the presence or absence of infection and in diseases associated to H. pylori and may contribute to the understanding of the biological and evolutionary importance of these genetic markers in infectious diseases.

Key words
Blood groups, ABO, Lewis, secretor phenotypes, secretor status, Helicobacter pylori

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