PREMEDICATION FOR ENDOTRACHEAL INTUBATION IN NEONATES

Abstract
Background: Intubation is commonly preformed in neonates requiring ventilatory support. Most intubations are done in an "awake" state without premedications. Objective: To review the literature on the efficacy/effectiveness of pharmacological agents used as premedication for intubation in neonates. Randomised controlled trials and cohort studies were included. Main results: Ten randomised controlled trials and 2 cohort studies were identified. In most studies, intubations were preformed under elective or semi-emergent situations. The combination was of atropine, fentanyl, and succinylcholine was evaluated more frequently. Attenuation of the physiological responses with shorter duration to perform intubation was demonstrated when premedications were used. Side effects such as chest wall rigidity was reported with fentanyl. Reviewer\'s conclusions: The use of premedication for intubation in neonates should be a routine practice. Individual units need to design a protocol suitable for their centre with ongoing surveillance to demonstrate benefits and identify any adverse events.

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Bibliografía del artículo

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