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Primera edición: 13 de Junio, 2005

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Especialidades
Principal: Infectología
Relacionadas: Diagnóstico por Imágenes,  Medicina Interna,  Medicina Interna,  Neurocirugía,  Oncología

Patrocinio y reconocimiento
Agradecimientos: El Manchester Children’s Tumour Registry es financiado por Cancer Research del Reino Unido. Jillian M. Birch es miembro de la cátedra de oncología pediátrica del Cancer Research del Reino Unido y Osborn B. Eden es profesor catedrático de oncología pediátrica del Cancer Research del Reino Unido en la Universidad de Manchester. También se agradece el apoyo financiero de la Fundación de Investigación del Hospital Christie (Christie Hospital Research Endowment).

EVIDENCE FOR AN INFECTIOUS COMPONENT TO THE AETIOLOGY OF CHILDHOOD BRAIN TUMOURS

Abstract
Background. A role for infections in the aetiology of childhood central nervous system (CNS) tumours has been proposed. Certain viruses have been linked with CNS tumours in animals and a small number of studies have found associations with childhood CNS tumours. Furthermore, there has been some evidence of viral genomic inclusions within childhood CNS tumour cells. The epidemiological evidence for an infectious component to aetiology is assessed. Materials, methods and results. Three descriptive studies on the incidence of childhood CNS tumours have been carried out using high quality data from a defined geographical area of North West England. These studies were concerned with space-time clustering and seasonal variation, spatial clustering and geographical variation and temporal trends. Space-time clustering and seasonal variation was found for cases of astrocytoma and ependymoma. Whilst no spatial clustering or geographical variability was apparent there have been recent temporal increases in the incidence of pilocytic astrocytoma, primitive neuroectodermal tumours and miscellaneous gliomas. Conclusions. The evidence from descriptive epidemiological studies from North West England is consistent with a role for infections in the aetiology of certain childhood CNS tumours, namely astrocytoma and ependymoma. The identity of candidate infections and indeed the mechanism of action still remain elusive.

Key words
Brain tumours, children, aetiology, infection, space-time clustering

Bibliografía del artículo

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