Resumen
La terapia de reemplazo hormonal (TRH) ha recibido apoyo generalizado como medida preventiva para la enfermedad de Alzheimer (EA). Sin embargo, estudios recientes indican que la TRH en realidad puede aumentar el riesgo de EA y de otras enfermedades neurodegenerativas en determinadas poblaciones. En el presente informe, revisamos estudios recientes, discutimos explicaciones y mecanismos posibles del aumento del riesgo observado y señalamos vías potenciales para la investigación futura.
Palabras clave
Terapia de reemplazo hormonal (TRH), estrógeno, progestina, demencia, enfermedad de Alzheimer, demencia frontotemporal
Clasificación en siicsalud
Artículos originales> Expertos del Mundo>
página www.siicsalud.com/des/des045/05921011.htm
Especialidades
Principal: Obstetricia y Ginecología
Relacionadas: Atención Primaria, Bioética, Bioquímica, Endocrinología y Metabolismo, Farmacología, Medicina Farmacéutica, Medicina Familiar, Medicina Interna, Salud Mental
Enviar correspondencia a: Andrew Levine. Department of Psychiatry & Biobehavioral Sciences. David Geffen School of Medicine at UCLA. 760 Westwood Plaza, Room C8-747, Los Angeles, CA 90024, EE.UU.
Patrocinio y reconocimiento La beca de investigación del Dr. Levine (T-32 MH19535) es financiada por el NIMH. Un agradecimiento especial a Sarah Spina por su arduo trabajo.
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HORMONE REPLACEMENT THERAPY AND THE RISK OF DEVELOPING DEMENTIA
Abstract
Hormone replacement therapy (HRT) has received widespread support as a preventative measure for Alzheimer’s disease (AD). However, recent studies have indicated that HRT may in fact raise the risk of AD and other neurodegenerative diseases in certain populations. In the current paper, we review these recent studies, discuss possible explanations and mechanisms for the observed increase in risk, and point out potential avenues for future research.
Key words
Hormone replacement therapy (HRT), estrogen, progestin, dementia, Alzheimer’s disease, frontotemporal dementia
Full text (english)
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Bibliografía del artículo
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