Resumen
Se sabe que la colonización bacteriana de la piel por Staphylococcus aureus desempeña un papel importante en la dermatitis atópica (DA). Recientemente se demostró el efecto antibacteriano de las telas con filamentos de plata sobre la colonización por S. aureus en un estudio comparativo, bilateral y de tipo abierto. Las telas con filamentos de plata redujeron significativamente la densidad de S. aureus luego de dos días de uso y su efecto persistió hasta el final (día 7) e incluso hasta una semana después de remover las telas. Además, hubo una diferencia significativa en la densidad de S. aureus cuando se compararon las telas con filamentos de plata con las telas de algodón. En paralelo, la gravedad clínica del eccema local disminuyó. Para investigar la eficacia clínica y funcional de las telas con filamentos de plata en la DA se llevó a cabo un estudio multicéntrico, a doble ciego, controlado con placebo. Estas telas fueron capaces de mejorar en forma significativa y de manera objetiva y subjetiva los síntomas de la DA dentro de las dos semanas y mostraron que su uso ofrecía mayor comodidad y funcionalidad que las telas de algodón sin efectos colaterales mensurables. Estos efectos terapéuticos produjeron una reducción significativa de las alteraciones en la calidad de vida después de transcurridas dos semanas. Más allá de la actividad antibacteriana potente de las telas con filamentos de plata in vivo, éstas demostraron una alta eficacia para reducir la gravedad clínica de la DA, con una comodidad en cuanto a su uso, comparable con las telas de algodón.
Palabras clave
Efecto antibacteriano, dermatitis atópica, iones de plata, Staphylococcus aeureus, telas
Clasificación en siicsalud
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página www.siicsalud.com/des/des047/06214009.htm
Especialidades
Principal: Dermatología
Relacionadas: Alergia, Medicina Interna
Enviar correspondencia a:
Anke Weidinger. Department of Dermatology and Allergy, BiedersteinTechnical University Munich, Alemania
Patrocinio y reconocimiento
“There are no financial conflicts of interest with regard to the contents of my article whatsoever and there has been no financial support.”
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SILVER COATED TEXTILES IN THERAPY OF ATOPIC ECZEMA
Abstract
Microbial skin colonization with Staphylococcus aureus is known to play an important role in atopic eczema (AE). Recently, an antibacterial effect of silver-coated textiles on S. aureus colonization has been demonstrated in an open side to side comparison. Silver coated textiles were able to reduce S. aureus density significantly after two days of wearing period, lasting until the end (day 7) and even one week after removal of the textiles. In addition, there was a significant difference in S. aureus density comparing silver coated to cotton textiles. In parallel, clinical severity of the local eczema was reduced. To investigate clinical efficacy and functionality of silver-coated textiles in generalized AE, a multicentre double-blind placebo-controlled trial was carried out. Silver coated textiles were able to improve objective and subjective symptoms of AE significantly within two weeks, showing a good wearing comfort and functionality comparable to cotton without measurable side effects. These therapeutic effects lead to a significantly lower impairment of quality of life, already after two weeks. Beside a potent antibacterial activity of silver coated textiles in vivo they demonstrate a high efficacy in reducing clinical severity of AE with a wearing comfort comparable to cotton.
Key words
Antibacterial effect, atopic eczema, silver ions, Staphylococcus aureus, textiles
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Bibliografía del artículo
- Leung DYM. Role of Staphylococcus aureus in atopic dermatitis. In: Atopic Dermatitis (Bieber T, Leung DYM, eds). New York, Basel: Marcel Dekker, Inc. 2002; 401-18.
- Bunikowski R, Mielke ME, Skarabis H et al. Evidence for a disease-promoting effect of Staphylococcus aureus-derived exotoxins in atopic dermatitis. J Allergy Clin Immunol 2000; 105:814-9.
- Yarwood JM, Leung DY, Schlievert PM. Evidence for the involvement of bacterial superantigens in psoriasis, atopic dermatitis, and Kawasaki syndrome. FEMS Microbiol Lett 2000; 192:1-7.
- Nomura I, Tanaka K, Tomita H et al. Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis. J Allergy Clin Immunol 1999; 104:441-6.
- Mempel M, Schmidt T, Weidinger S et al. Role of Staphylococcus aureus surface-associated proteins in the attachment to cultured HaCaT keratinocytes in a new adhesion assay. J Invest Dermatol 1998; 111:452-6.
- Leung DYM. Atopic dermatitis: the skin as a window into the pathogenesis of chronic allergic diseases. J Allergy Clin Immunol 1995; 96:302-18.
- Ring J, Abeck D, Neuber K. Atopic eczema: role of microorganisms on the skin surface. Allergy 1992; 47:265-9.
- Williams REA, Gibson AG, Aitchinson TC et al. Assessment of a contact-plate sampling technique and subsequent quantitative bacterial studies in atopic dermatitis. Br J Dermatol 1990; 123:493-501.
- Bode U, Ring J, Neubert U. Intrakutantestungen und bakteriologische Untersuchungen bei Patienten mit atopischem Ekzem. Allergologie 1982; 5:259-61.
- Fischer S, Ring J, Abeck D: Atopic eczema. Spectrum of provovocation factors and possibilities for their effective reduction and elimination. Hautarzt 2003; 54:914-24.
- Abeck D, Bleck O, Ring J. Skin barrier and eczema. In: Ring J, Behrendt H, Vieluf D, editors. New Trends in Allergy IV. Berlin. Springer. 1996; 213-220.
- Bleck O, Abeck D, Ring J et al. Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of nonlesional skin of atopic eczema. J Invest Dermatol. 1999; 113:894-900.
- Imokawa G, Abe A, Jin K et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin J Invest Dermatol. 1991; 96:523-526.
- Murata Y, Ogata J, Higaki Y et al. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency J Invest Dermatol. 1996; 106:1242-1249.
- Werner Y, Lindberg M. Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol. 1985; 65:102-105.
- Ring J, Brockow K, Abeck D. The therapeutic concept of patient management in atopic eczema. Allergy 1996; 51:206-15.
- Feng QL, Wu J, Chen GQ et al. A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res 2000; 52:662-8.
- Hollinger MA. Toxicological aspects of topical silver pharmaceuticals. Crit Rev Toxicol 1996; 26:255-60.
- Stalder JF, Fleury M, Sourisse M et al. Comparative effect of two topical antiseptics (chlorhexidine vs KMn04) on bacterial skin flora in atopic dermatitis. Acta Derm Venereol (Stockh.) 1992; Suppl. 176:132-34.
- Bosetti M, Masse A, Tobin E et al. Silver coated materials for external fixation devices: in vitro biocompatibility and genotoxicity. Biomaterials 2002; 23:887-92.
- Schaeffer AJ, Story KO, Johnson SM: Effect of silver oxide/trichloroisocyanuric acid antimicrobial urinary drainage system on catheter-associated bacteriuria. J Urol 1988; 139:69-73.
- Matsura T, Abe Y, Sato Y et al. Prolonged antimicrobial effect of tissue conditioners containing silver zeolite. J Dent 1997; 25:373-7.
- Lansdown AB. Silver. I: Its antibacterial properties and mechanism. J Wound Care 2002; 11:125-30.
- Gauger A, Mempel M, Schekatz A et al. Silver-coated textiles reduce Staphylococcus aureus colonization in patients with atopic eczema. Dermatology 2003; 207:15-21.
- Gauger A, Fischer S, Mempel M et al. Efficacy and functionality of silver-coated textiles in patients with atopic eczema. JEADV 2005; accepted BioService: Test 001118. 2001.
- Brockow K, Grabenhorst P, Abeck D et al. Effect of gentian violet, corticosteroid and tar preparations in Staphylococcus-aureus-colonized atopic eczema. Dermatology 1999; 199:231-236.
- Kunz B, Oranje AP, Labreze L et al. Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology. 1997; 195:10-11.
- European Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis. The SCORAD index. Consensus report of the European Task force on Atopic Dermatitis. Dermatology. 1993; 186:23-31.
- Grob JJ, Revuz J, Ortonne JP et al. Comparative study of the impact of chronic urticaria, psoriasis and atopic dermatitis on the quality of life. Br J Dermatol. 2005;152:289-95.
- Abeck D, Strom K. Optimal management for atopic dermatitis. Am J Clin Dermatol. 2000; 1:41-46.
- Lever R, Hadley K, Downey D et al. Staphylococcal colonization in atopic dermatitis and the effect of topical mupiricin therapy. Br J Dermatol. 1988; 119:189-198.
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