Resumen
La urotensina II (U-II) humana es uno de los vasoconstrictores más fuertes en los mamíferos, es incluso más potente que la endotelina. Tiene un amplio espectro de propiedades vasoactivas según su localización anatómica y las especies estudiadas. Si bien se expresa fundamentalmente en el cerebro y en la médula espinal, también se la detecta en otros tejidos como el riñón. Aunque se la conoce desde hace más de 30 años, sólo recientemente se transformó en un objetivo principal de las investigaciones clínicas. Se sugirió que la U-II podría tener funciones autocrinas/paracrinas en el riñón y que podría ser una importante molécula blanco en el estudio de la fisiopatología renal. Con anterioridad investigamos el nivel de U-II en niños con síndrome nefrótico de cambios mínimos (SNCM) y según nuestro conocimiento no existe ningún estudio acerca del posible papel de la U-II en otras glomerulonefritis infantiles. En primer lugar determinamos la expresión de la U-II en riñones de niños con varias enfermedades glomerulares. En función de la literatura y de nuestros hallazgos, en esta revisión se describe esencialmente el posible papel de la U-II en niños con enfermedades renales y se resumen los conocimientos disponibles y lo que resta saber acerca de la U-II.
Palabras clave
niños, glomerulonefritis, síndrome nefrótico, urotensina II
Clasificación en siicsalud
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página www.siicsalud.com/des/des053/07605001.htm
Especialidades
Principal: Nefrología y Medio Interno
Relacionadas: Bioquímica, Diagnóstico por Laboratorio, Pediatría, Urología
Enviar correspondencia a:
Ayse Balat, Department of Pediatrics, Medical Faculty, Gaziantep University, 27310, Gaziantep, Turquía
Patrocinio y reconocimiento
Agradecimiento: a Metin Karakök, del Departamento de Patología de la Universidad de Gaziantep por su ayuda en la obtención de las figuras.
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UROTENSIN-II IN CHILDREN WITH RENAL DISEASES: NEW MESSAGES FROM AN ANCIENT PEPTIDE
Abstract
Human urotensin-II (hU-II) is one of the most potent vasoconstrictors in mammals, even more potent than endothelin. It has a wide range of vasoactive properties dependent on the anatomic site and the species studied. Although it is expressed mainly in the brain and spinal cord, it is also detected in other tissues, such as the kidney. It has been recognized for over 30 years, however only recently it has become a major focus of clinical researches. It has been suggested that U-II may have a possible autocrine/paracrine functions in kidney, and may be an important target molecule in studying renal pathophsiology. Previously, we investigated the level of U-II in children with minimal change nephrotic syndrome (MCNS), and to our knowledge there is no study about the possible role of U-II in other childhood glomerulonephritis. We firstly determined the expression of h U-II in kidneys of children with several glomerular diseases. In the lights of literature and our findings, this review describes mainly the possible role of U-II in children with renal diseases and summarizes what is known, and what must be known about the U-II.
Key words
children, glomerulonephritis, nephrotic syndrome, urotensin-II
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Bibliografía del artículo
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