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REVISION ACERCA DEL ENFOQUE DE LOS TUMORES NEUROENDOCRINOS BIEN DIFERENCIADOS (especial para SIIC © Derechos reservados) |
| Se presenta una actualización del enfoque diagnóstico y el abordaje terapéutico de las neoplasias neuroendocrinas bien diferenciadas, incluidos los tumores carcinoides y las variantes de localización pancreática, con hincapié en las aplicaciones de las nuevas terapias moleculares dirigidas. |
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Autor: Diane Reidy-lagunes Columnista Experta de SIIC Institución: Memorial Sloan-Kettering Cancer Center Artículos publicados por Diane Reidy-lagunes |
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Coautor Wyluda Ed * DO, Memorial Sloan-Kettering Cancer Center, Nueva York, EE.UU.* |
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Recepción del artículo 26 de Abril, 2011 |
Aprobación 12 de Julio, 2011 |
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Primera edición 29 de Septiembre, 2011 |
Segunda edición, ampliada y corregida 27 de Marzo, 2012 |
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ResumenLos tumores neuroendocrinos bien diferenciados (TNE) son neoplasias malignas poco frecuentes que incluyen tanto los carcinoides como los tumores neuroendocrinos pancreáticos (TNEP). Estos tumores se asocian en general con metástasis en el momento del diagnóstico. Si bien la supervivencia prolongada es frecuente, la supervivencia global se reduce de manera acentuada cuando los pacientes presentan síntomas, así como cuando el tumor progresa pese a la terapia con análogos de la somatostatina. Aunque estos fármacos pueden contribuir a tratar la sintomatología y ralentizar el crecimiento tumoral, en especial en neoplasias de bajo grado, no se ha demostrado que el tratamiento a largo plazo sea eficaz en estos pacientes. Recientemente, los ensayos preclínicos y dos estudios de fase III han brindado avances promisorios, sobre todo en el tratamiento de los TNEP. La aparición de terapias dirigidas contra el factor de crecimiento vascular endotelial (VEGF), los inhibidores de la diana de la rapamicina (mTOR) y el tratamiento con receptores de péptidos radiomarcados se ha asociado con eficacia moderada, pero pueden vincularse con toxicidad relevante. En esta revisión, discutiremos los ensayos recientes y las terapias actuales de los TNE bien diferenciados.
Palabras clavetumores neuroendocrinos bien diferenciados, tumor neuroendocrino pancreático, carcinoide Clasificación en siicsalud Artículos originales > Expertos del Mundo > página www.siicsalud.com/des/expertocompleto.php/ Especialidades 
Principal: Oncología
Relacionadas: Anatomía Patológica,
Diagnóstico por Imágenes,
Diagnóstico por Laboratorio,
Endocrinología y Metabolismo,
Farmacología,
Gastroenterología,
Geriatría,
Medicina Farmacéutica,
Medicina Interna,
Medicina Nuclear
Enviar correspondencia a:Diane, Reidy-Lagunes, Memorial Sloan-Kettering Cancer Center, 275 York Avenue, Room H-917, NY 10065, Nueva York, EE.UU., E-mail: reidyd@mskcc.org
Updates on advanced well-differentiated neuroendocrine tumors
Bibliografía del artículo
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