Appendicular lean mass and the risk of stroke and Alzheimer's disease: a mendelian randomization study.

Appendicular lean mass and the risk of stroke and Alzheimer's disease: a mendelian randomization study.

Fuente:Bmc Geriatrics

Extracto: The two-sample MR analysis indicated that genetically predicted ALM was negatively related to AIS and AD. And the subgroup analysis of AIS revealed a negative causal effect of genetically predicted ALM on LAS or SVS. Future studies are required to further investigate the underlying mechanisms.

Claves:Alzheimer’s disease, Appendicular lean mass, Mendelian randomization, Sarcopenia, Stroke

Cita:BMC Geriatr 2024 May 18; 24 (1) : 438.

Autor/es:Zhu, Yueli (a)
Zhu, Feng (b)

institución:(a) Department of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
(b) Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12877-024-05039-5

AI-enhanced integration of genetic and medical imaging data for risk assessment of Type 2 diabetes.

AI-enhanced integration of genetic and medical imaging data for risk assessment of Type 2 diabetes.

Fuente:Nature Communications

Extracto: Moreover, we introduce an accessible online risk assessment tool for T2D, facilitating broader applicability and dissemination of our findings.

Cita:Nat Commun 2024 May 18; 15 (1) : 4230.

Autor/es:Huang, Yi-Jia (a)
Chen, Chun-Houh (b)

institución:(a) Institute of Public Health, National Yang-Ming Chiao-Tung University, Taipei, Taiwan.
(b) Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48618-1

A randomized controlled trial to compare the effects of time-restricted eating versus Mediterranean diet on symptoms and quality of life in bipolar disorder.

A randomized controlled trial to compare the effects of time-restricted eating versus Mediterranean diet on symptoms and quality of life in bipolar disorder.

Fuente:Bmc Psychiatry

Tipo de trabajo:Orientaciones y guía

Extracto: TRIAL REGISTRATION: ClinicalTrials.gov ID NCT06188754.

Claves:Bipolar disorder, Circadian, Depression, Mania, Mediterranean diet, Quality of life, Randomized controlled trial, Time-restricted eating

Cita:BMC Psychiatry 2024 May 18; 24 (1) : 374.

Autor/es:Johnson, Sheri L (a)
Murray, Greg (b)

institución:(a) Department of Psychology, University of California, Berkeley, USA. sljohnson@berkeley.edu.
(b) Centre for Mental Health, Swinburne University, Melbourne, VIC, 3122, Australia.

Conflicto:SJ has received funding from Genentech/LaRoche, NIMH, the NCI, the NSF, Peder Sather Fund, and NARSAD (none of which focus on circadian rhythms or dietary intervention). LJK has received funding from NIMH, NICHD, NIA, NSF, UC Berkeley Radical Ideas in Brain Science Award, UC Berkeley Hellman Family Faculty Fund Award, UC Berkeley Junior Faculty Research Grant, UC-Mexus Collaborative Grant, Fonds... France-Berkeley Fund, Berkeley Faculty Research Fund for Biological Sciences, Juvenile Diabetes Research Foundation, Donations from Optoceutics Inc, Sona Inc, and Intuitive Foundation (none of which focus on bipolar disorder). SP is a consultant for Hooke London, the author of The Circadian Code and The Circadian Diabetes Code, but none of those engagements overlap with protocol, and none focus on bipolar disorder. Others have no conflicts to report that are relevant to this work. Potential conflicts of interest will be reviewed by the University of California Committee on Conflicts of Interest annually, and their guidance will be followed in managing potential conflicts.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12888-024-05790-4

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study.

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study.

Fuente:Scientific Reports

Extracto: Further studies need to evaluate the effects on eating behavior and metabolism.

Cita:Sci Rep 2024 May 18; 14 (1) : 11341.

Autor/es:Ester-Nacke, Theresa (a)
Berti, Katharina (b)

institución:(a) Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany. Theresa.ester@med.uni-tuebingen.de.
(b) Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, Eberhard Karls University Tübingen, Tübingen, Germany. Theresa.ester@med.uni-tuebingen.de.

Conflicto:GR is a co-founder and shareholder and works for Neuroelectrics, a company developing medical devices for NIBS. RS works for Neuroelectrics. Outside of the current work, MH reports research grants from Boehringer Ingelheim and Sanofi to the University Hospital of Tübingen, participation in advisory board for Boehringer Ingelheim, Sanofi and Amryt, and lecture fees from Amryt, Bayer, Sanofi, Eli Lilly,... , Novartis, Novo Nordisk and Boehringer Ingelheim. TEN, KB, RV, CD, ALB, CP, HP and SK report no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-61852-3

Circulating total and H-specific GDF15 levels are elevated in subjects with MASLD but not in hyperlipidemic but otherwise metabolically healthy subjects with obesity.

Circulating total and H-specific GDF15 levels are elevated in subjects with MASLD but not in hyperlipidemic but otherwise metabolically healthy subjects with obesity.

Fuente:Cardiovascular Diabetology

Extracto: Serum GDF15 levels do not differ in relation to weight status in hyperlipidemic but otherwise metabolically healthy individuals. In contrast, GDF15 levels are significantly increased in MASLD patients at baseline and they remain significantly higher compared to healthy participants during OGTT, pointing to a role for GDF15 as a mitokine with important roles in the pathophysiology and possibly therapeutics of MASLD. Trial registration ClinicalTrials.gov NCT03986684, NCT04430946.

Claves:C-peptide, GIP, Growth differentiation factor 15, Mixed meal test, Non-alcoholic fatty liver disease, Obesity, Oral glucose tolerance test

Cita:Cardiovasc Diabetol 2024 May 18; 23 (1) : 174.

Autor/es:Boutari, Chrysoula (a)
Stefanakis, Konstantinos (b)

institución:(a) Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA.
(b) Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, SL418, Boston, MA, 02215, USA.

Conflicto:CB, KS, VG, LV-V, SS and IAA have nothing to declare. MAC is an employee of and holds stock in Labcorp. AK has received grants through his institution and consulting fees from Novo Nordisk, Pharmaserve Lilly, Elpen pharmaceuticals, as well as consulting fees from Astra Zeneca, MSD, Sanofi, Bausch Health, Ethicon, Galenica Pharma, and Epsilon Health. None is related to... the work presented herein. CSM reports grants through his institution from Merck and Boehringer Ingellheim, grants through his institution and personal consulting fees from Coherus Inc., AltrixBio, and reports personal consulting fees and support with research reagents from Ansh Inc., reports personal consulting fees from Genfit, Lumos, Amgen, Corcept, Intercept, 89Bio, AstraZeneca and Regeneron, reports travel support and fees from TMIOA, Elsevier, College Internationale Research Servier and the Cardio Metabolic Health Conference. None is related to the work presented herein.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12933-024-02264-5

Assessment between antiseptic and normal saline for negative pressure wound therapy with instillation and dwell time in diabetic foot infections.

Assessment between antiseptic and normal saline for negative pressure wound therapy with instillation and dwell time in diabetic foot infections.

Fuente:Scientific Reports

Extracto: The findings of the study suggest that the use of either PHMB-B or normal saline as an instillation solution in NPWTi-d for DFIs shows promise and effectiveness, yet no clinical distinction was observed between the two solutions.

Claves:Diabetic foot infection, Instillation and dwell time, Negative pressure wound therapy, PHMB

Cita:Sci Rep 2024 May 19; 14 (1) : 11423.

Autor/es:Zhao, Jingchun (a)
Shi, Kai (b)

institución:(a) Department of Burn Surgery, the First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, People's Republic of China.
(b) Department of Burn Surgery, the First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58900-3

A Comprehensive Review on Weight Gain following Discontinuation of Glucagon-Like Peptide-1 Receptor Agonists for Obesity.

Fuente:Journal of Obesity

Extracto: Clinical studies should emphasize the downside of these views we highlighted, and mechanistic studies must be carried out for a better outcome with GLP-1RA from the laboratory to the bedside.

Cita:J Obes 2024; 2024 : 8056440.

Autor/es:Clinical studies should emphasize the downside of these views we highlighted, and mechanistic studies must be carried out for a better outcome with GLP-1RA from the laboratory to the bedside.

institución:Clinical studies should emphasize the downside of these views we highlighted, and mechanistic studies must be carried out for a better outcome with GLP-1RA from the laboratory to the bedside.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1155/2024/8056440

NET-Related Gene as Potential Diagnostic Biomarkers for Diabetic Tubulointerstitial Injury.

NET-Related Gene as Potential Diagnostic Biomarkers for Diabetic Tubulointerstitial Injury.

Fuente:Journal of Diabetes Research

Extracto: Furthermore, NRGs involved in diabetic tubulointerstitial injury could emerge as prospective targets for the diagnosis and treatment of DKD.

Claves:NETosis, bioinformatics, diabetic kidney disease, immune characteristics, tubulointerstitial injury

Cita:J Diabetes Res 2024; 2024 : 4815488.

Autor/es:Liang, Yufeng (a)
Lin, Jiaqun (b)

institución:(a) Department of Nephrology, Blood Purification Research Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
(b) Department of Nephrology, The Second Hospital of Longyan, Longyan, Fujian 364000, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1155/2024/4815488

Balance performance, falls-efficacy and social participation in patients with type 2 diabetes mellitus with and without vestibular dysfunction.

Balance performance, falls-efficacy and social participation in patients with type 2 diabetes mellitus with and without vestibular dysfunction.

Fuente:Peerj

Extracto: The presence of VD in T2DM patients was associated with decreased physical balance performances and increased social and QoL disengagement. Comprehensive management related to balance and FE, as well as the monitoring to support social participation and QoL, should be emphasized in patients with T2DM with VD.

Claves:Falls-efficacy, Quality of life, Social participation, Type 2 diabetes mellitus, Vestibular dysfunction, Balance performance

Cita:PeerJ 2024; 12 : e17287.

Autor/es:Komalasari, Dwi Rosella (a)
Vongsirinavarat, Mantana (b)

institución:(a) Physiotherapy, Muhammadiyah University of Surakarta, Surakarta, Central Java, Indonesia.
(b) Physical Therapy, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom, Thailand.

Conflicto:The authors declare there are no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.7717/peerj.17287

A national audit of facilities, human and material resources for the comprehensive management of diabetes in Ghana-A 2023 update.

A national audit of facilities, human and material resources for the comprehensive management of diabetes in Ghana-A 2023 update.

Fuente:Plos One

Tipo de trabajo:Guía

Extracto: An urgent multisectoral collaboration, including prioritisation of resources at the facility level, to promote and achieve acceptable comprehensive diabetes care is required.

Cita:PLoS One 2024; 19 (5) : e0303624.

Autor/es:Yorke, Ernest (a)
Akpalu, Josephine (b)

institución:(a) Department of Medicine & Therapeutics, University of Ghana Medical School, College of Health Sciences, Accra, Ghana.
(b) Department of Medicine & Therapeutics, University of Ghana Medical School, College of Health Sciences, Accra, Ghana.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303624

Exploring the path to optimal diabetes care by unravelling the contextual factors affecting access, utilisation, and quality of primary health care in West Africa

Fuente:Plos One

Tipo de trabajo:Revisión

Extracto: This review protocol aims to systematically examine and assess the factors that impact the access, utilisation, and standard of primary healthcare services for diabetes in West Africa.

Cita:PLoS One 2024; 19 (5) : e0294917.

Autor/es:Abdul-Samed, Abdul-Basit (a)
Peprah, Ellen Barnie (b)

institución:(a) Ghana College of Physicians and Surgeons, Accra, Ghana.
(b) Ghana College of Physicians and Surgeons, Accra, Ghana.

Conflicto:We declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0294917

Factors associated with oral health care behavior of people with type 2 diabetes mellitus: A hospital-based, cross-sectional study.

Fuente:Plos One

Extracto: People with T2DM had good oral health status. People with T2DM with low oral health literacy, low attitude, and low level of oral health services were at a higher risk of poor oral healthcare behavior.

Cita:PLoS One 2024; 19 (5) : e0303530.

Autor/es:Sairat, Kamonchanok (a)
Phoosuwan, Nitikorn (b)

institución:(a) Faculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon Province, Thailand.
(b) Sub-District Health Promotion Hospitals in Bueng Khong Long, Buengkan Province, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303530

Design of a bi-directional methodology for automated assessment of compliance to continuous application of clinical guidelines, and its evaluation in the type 2 diabetes domain.

Fuente:Plos One

Extracto: We conclude that systems such as DiscovErr can effectively assess the quality of continuous guideline-based care.

Cita:PLoS One 2024; 19 (5) : e0303542.

Autor/es:Hatsek, Avner (a)
Hochberg, Irit (b)

institución:(a) Department of Software and Information Systems Engineering, Ben Gurion University, Beer Sheva, Israel.
(b) Endocrinology, Diabetes, and Metabolism Institute, Rambam Health Care Campus, Haifa, Israel.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303542

A novel fusion of genetic grey wolf optimization and kernel extreme learning machines for precise diabetic eye disease classification.

Fuente:Plos One

Extracto: Our findings are crucial to enhancing diagnostic accuracy and patient outcomes in DED management.

Cita:PLoS One 2024; 19 (5) : e0303094.

Autor/es:Khan, Abdul Qadir (a)
Sun, Guangmin (b)

institución:(a) Faculty of Information Technology, Beijing University of Technology, Beijing, China.
(b) Faculty of Information Technology, Beijing University of Technology, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303094

Transgender health objectives of training for adult Endocrinology and Metabolism programs: Outcomes of a modified-Delphi study.

Fuente:Plos One

Tipo de trabajo:Consenso

Extracto: To our knowledge, this is the first time a consensus-based approach has been used to establish THOOT for any subspecialty postgraduate medicine program across Canada or the United States. Our results lay the foundation towards health equity and social justice in transgender health medical education, offering a blueprint for future innovations.

Cita:PLoS One 2024; 19 (5) : e0301603.

Autor/es:Ahmad, Tehmina (a)
Schreyer, Leighton (b)

institución:(a) Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, ON, Canada.
(b) Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301603

Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes.

Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes.

Fuente:Nature Communications

Extracto: Our results point to multiple drugs with therapeutic potentials, including metformin for type 1 diabetes, and vitamin K for ulcerative colitis.

Cita:Nat Commun 2024 May 20; 15 (1) : 4260.

Autor/es:Wang, Lida (a)
Khunsriraksakul, Chachrit (b)

institución:(a) Department of Public Health Sciences; Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
(b) Bioinformatics and Genomics PhD Program; Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48143-1

Air pollution, life's essential 8, and risk of severe non-alcoholic fatty liver disease among individuals with type 2 diabetes.

Air pollution, life's essential 8, and risk of severe non-alcoholic fatty liver disease among individuals with type 2 diabetes.

Fuente:Bmc Public Health

Extracto: Our findings suggest that long-term exposure to air pollution was associated with an elevated risk of severe NAFLD among participants with T2D. A lower LE8 may increase the adverse impacts of air pollution on NAFLD.

Claves:Air pollution, Life’s Essential 8 (LE8), Non-alcoholic fatty liver disease (NAFLD), Type 2 diabetes (T2D)

Cita:BMC Public Health 2024 May 20; 24 (1) : 1350.

Autor/es:Aimuzi, Ruxianguli (a)
Xie, Zhilan (b)

institución:(a) School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
(b) School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18641-4

Glomerular crescents are associated with the risk of type 2 diabetic kidney disease progression

Glomerular crescents are associated with the risk of type 2 diabetic kidney disease progression

Fuente:Bmc Nephrology

Tipo de trabajo:Estudio de cohortes

Extracto: The presence of glomerular crescents is indeed linked to the progression of type 2 DKD. Therefore, it is important to determine whether there is an additional immune-mediated glomerulonephritis requiring immunomodulation, and it may be prudent to monitor the histology and repeat a biopsy.

Claves:Biopsy, Crescent, Diabetic kidney disease, Diabetic nephropathy, Histology

Cita:BMC Nephrol 2024 May 20; 25 (1) : 172.

Autor/es:Bae, Sohyun (a)
Yun, Donghwan (b)

institución:(a) Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-Ro, Jongno-Gu, Seoul, 03080, Korea.
(b) Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-Ro, Jongno-Gu, Seoul, 03080, Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12882-024-03578-y

ABO and Rhesus blood groups and multiple health outcomes

ABO and Rhesus blood groups and multiple health outcomes

Fuente:Bmc Medicine

Tipo de trabajo:Revisión sistemática

Extracto: Our findings suggest a potential relationship between ABO and Rh blood groups and adverse health outcomes. Particularly the association between blood group B and type 2 diabetes mellitus risk.

Claves:ABO blood group, Meta-analysis, Observational study, Rhesus blood group, Umbrella review

Cita:BMC Med 2024 May 20; 22 (1) : 206.

Autor/es:Liu, Fang-Hua (a)
Guo, Jia-Kai (b)

institución:(a) Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
(b) Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12916-024-03423-x

Analysis of causes and prognostic impact of tube occlusion during hyperthermic intraperitoneal chemotherapy for appendiceal pseudomyxoma peritonei.

Analysis of causes and prognostic impact of tube occlusion during hyperthermic intraperitoneal chemotherapy for appendiceal pseudomyxoma peritonei.

Fuente:World Journal of Surgical Oncology

Extracto: Tubing blockages are a common occurrence during HIPEC treatment, leading to prolonged postoperative gastrointestinal functional recovery time. When patients are elderly and have concomitant hypertension and diabetes, along with a histological type of low-grade mucinous tumor, the risk of tube occlusion increases. However, this study did not find a significant correlation between tubing blockage and the incidence of postoperative complications or overall patient survival.

Claves:Complication, Gastrointestinal function, HIPEC, Tube occlusion

Cita:World J Surg Oncol 2024 May 21; 22 (1) : 134.

Autor/es:Liu, Qi (a)
Jiao, Jie (b)

institución:(a) School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.
(b) Department of Gastrointestinal Surgery, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12957-024-03412-7