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While most of the selected texts belong to original articles,
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First-year outcomes of very low birth weight preterm singleton infants with hypoxemic respiratory failure treated with milrinone and inhaled nitric oxide (iNO) compared to iNO alone: A nationwide retrospective study.
First-year outcomes of very low birth weight preterm singleton infants with hypoxemic respiratory failure treated with milrinone and inhaled nitric oxide (iNO) compared to iNO alone: A nationwide retrospective study.
Fuente:Plos One
Tipo de trabajo:Estudio de cohortes
Extracto:
Combined treatment of iNO and milrinone is
increasingly applied in VLBWP infants in Taiwan. This retrospective study did not
support the benefits of combining iNO and milrinone on one-year survival and BPD
prevention. A future prospective study is warranted.
Cita:PLoS One 2024; 19 (5) : e0297137.
Autor/es:Chang, Ya-Ting (a) Liu, Jia-Rou (b)
institución:(a) Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Taoyuan City, Taiwan. (b) Department of Public Health, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical usability of 3D gradient-echo-based ultrashort echo time imaging: Is it enough to facilitate diagnostic decision in real-world practice?
Clinical usability of 3D gradient-echo-based ultrashort echo time imaging: Is it enough to facilitate diagnostic decision in real-world practice?
Fuente:Plos One
Extracto:
Our study showed the potential
of CODE and VIBE sequences in the evaluation of localized thoracic abnormalities
including solid pulmonary nodules.
Cita:PLoS One 2024; 19 (5) : e0296696.
Autor/es:Bak, So Hyeon (a) Park, Jinil (b)
institución:(a) Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. (b) Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Conflicto:None of the authors have potential conflicts of interest to disclose.
Health-related quality of life and impact of socioeconomic status among primary and secondary school students after the third COVID-19 wave in Berlin, Germany.
Health-related quality of life and impact of socioeconomic status among primary and secondary school students after the third COVID-19 wave in Berlin, Germany.
Fuente:Plos One
Extracto:
Support strategies
for psychosocial wellbeing should consider socioeconomically disadvantaged
children as important target groups.
Cita:PLoS One 2024; 19 (5) : e0302995.
Autor/es:Kern, Mascha (a) Glatz, Toivo (b)
institución:(a) Institute of Public Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. (b) Institute of International Health, Charité Center for Global Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Conflicto:None of the authors had a conflict of interest related to the content of the study. Outside the work, TK reports to have received research grants from the Gemeinsamer Bundesausschuss (G-BA, Federal Joint Committee, Germany), the Bundesministerium für Gesundheit (BMG, Federal Ministry of Health, Germany). He further has received personal compensation from Eli Lilly and Company, Teva Pharmaceuticals, TotalEnergies S.E.,...
, The BMJ, and Frontiers. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Extracto:
It is crucial at this time to reflect on
the factors that influence parental decisions surrounding immunization to
facilitate more informed discussions, enhance healthcare communication, and
contribute to the design of effective RSV prevention strategies that resonate
with the concerns and aspirations of parents worldwide.
Cita:Hum Vaccin Immunother 2024 Dec 31; 20 (1) : 2341505.
Autor/es:Treston, Bryony (a) Geoghegan, Sarah (b)
institución:(a) Department of Paediatric Infectious Diseases, Children's Health Ireland at Crumlin and Temple Street, Dublin, Ireland. (b) Department of Paediatric Infectious Diseases, Children's Health Ireland at Crumlin and Temple Street, Dublin, Ireland.
Conflicto:No potential conflict of interest was reported by the author(s).
Genomic characterization of Influenza A (H1N1)pdm09 and SARS-CoV-2 from Influenza Like Illness (ILI) and Severe Acute Respiratory Illness (SARI) cases reported between July-December, 2022.
Genomic characterization of Influenza A (H1N1)pdm09 and SARS-CoV-2 from Influenza Like Illness (ILI) and Severe Acute Respiratory Illness (SARI) cases reported between July-December, 2022.
Fuente:Scientific Reports
Extracto:
Thus
continuous genomic surveillance is required to tackle any future outbreak.
Claves:COVID-19, Co-infection, ILI/SARI case, Influenza A (H1N1)pdm09, SARS-CoV-2
institución:(a) Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India. (b) Department of Microbiology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.
A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.
Fuente:Nature Communications
Extracto:
This work identifies an important biomarker and
targetable pathways for the treatment of mucus obstruction in asthma.
Cita:Nat Commun 2024 May 9; 15 (1) : 3900.
Autor/es:Everman, Jamie L (a) Sajuthi, Satria P (b)
institución:(a) Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA. (b) Center for Genes, Environment, and Health, National Jewish Health, Denver, CO, USA.
Conflicto:On behalf of the SARP study: The following companies provided financial support for study activities at the Coordinating and Clinical Centers beyond the third year of SARP patient follow-up: AstraZeneca, Boehringer-Ingelheim, Genentech, GlaxoSmithKline, Sanofi–Genzyme–Regeneron, and TEVA. These companies had no role in study design, data collection, or data analysis, nor preparation of the manuscript or decision to publish, and the...
the only restriction on the funds was that they be used to support the SARP initiative. The authors of this manuscript report the following COIs: J.L.E. is listed as an inventor on the filed patent application by National Jewish Health, PCT/US24/11470 titled “Methods and Compositions for Treating Mucus Obstruction in Severe Asthma.” V.E.O. has received compensation for his role in Independent Data and Monitoring Committees for trials sponsored by Regeneron and Sanofi. B.M.E. receives consulting fees from Aer Therapeutics LLC, and receives stocks for service on the company board. B.M.E. is listed as one of the inventors on a filed patent application for lung image-based scoring systems that quantify mucus plug burden in the lung. T.S.H. is a stockholder and advisor for Aer Therapeutics LLC. M. Castro reports grants/research support from NIH, ALA, PCORI, AstraZeneca, Gala Therapeutics, Genentech, GSK, Novartis, Pulmatrix, Sanofi-Aventis, Shionogi, and Theravance. M. Castro receives consulting fees from Allakos, Amgen, Arrowhead Pharmaceuticals, Genentech, GSK, Merck, Novartis, OM Pharma, Pfizer, Pioneering Medicines, Sanofi-Aventis, and Teva, and receives payment for speaker’s bureau activities from Amgen, AstraZeneca, Genentech, Regeneron, Sanofi-Aventis, and Teva. M. Castro receives stock options from Aer Therapeutics. E.I. reports grants/research support or research materials from NHLBI, NIH, AstraZeneca, Avillion, Gossamer Bio, PCORI, Circassia, Genentech, TEVA, Sun Pharma, Laurel Pharmaceuticals, Om Pharma, Nestle, CSL Behring, AMSA, and Sanofi-Regeneron. E.I. receives consulting fees from AB Science, Allergy and Asthma Network, Amgen, Arrowhead Pharmaceuticals, AstraZeneca, GlaxoSmithKline, Merck, NHLBI, PPS Health, Regeneron, Sanofi Genzyme, TEVA, Cowen, Guidepoint, Windrose Consulting Group, and Reach Market Research. E.I. reports royalties from Wolters Kluwer, and speaker fees from Westchester Medical Center and Clearview Health Partners. E.I. has provided expert testimony for Cambridge Medical Experts. E.I. has received compensation for participation in the Data Safety Monitoring Board for Novartis, as a member of the coordinating committee in NAEPP: National Asthma Education Prevention Program, and stock options for Vorso. B.D.L., D.T.M., K.S., and L.D. reports grant funding support for SARP study activities at the Coordinating and Clinical Centers beyond the third year of SARP patient follow-up from AstraZeneca, Boehringer-Ingelheim, Genentech, GlaxoSmithKline, Sanofi–Genzyme–Regeneron, and TEVA. K.S. has received advisory fees from AstraZeneca. D.S.G. is listed as one of the inventors on a filed patent application for lung image-based scoring systems that quantify mucus plug burden in the lung. A.T.H. has received grants/research support for this study from NHLBI, and for SARP study activities at the Coordinating and Clinical Centers beyond the third year of SARP patient follow-up from AstraZeneca, Boehringer-Ingelheim, Genentech, GlaxoSmithKline, Sanofi–Genzyme–Regeneron, and TEVA. W.C.M. reports grant funding support from NHLI and ALA, and reports grant funding support for SARP study activities at the Coordinating and Clinical Centers beyond the third year of SARP patient follow-up from AstraZeneca, Boehringer-Ingelheim, Genentech, GlaxoSmithKline, Sanofi–Genzyme–Regeneron, and TEVA. L.D. also reports grant funding from NHLBI and ALA-ACRC, consulting fees from OM Pharma, research support/research equipment and materials from GlaxoSmithKline, Laurel, Sun Pharma, Vifor/OM Pharma, Vitaeris/CSL Behring, and Vitaflo. N.N.J. has previously received consulting fees from GlaxoSmithKline and AstraZeneca. S.E.W. is a Primary Investigator on an ongoing investigational research study with Regeneron. P.G.W. is a consultant with Regeneron, Sanofi, AstraZeneca, and Roche. J.V.F. reports grant funding from NIH/NHLBI, and reports grant funding support for SARP study activities at the Coordinating and Clinical Centers beyond the third year of SARP patient follow-up from AstraZeneca, Boehringer-Ingelheim, Genentech, GlaxoSmithKline, Sanofi–Genzyme–Regeneron, and TEVA. J.V.F. is the inventor of granted patents describing thiol modified saccharides as drugs to treat mucus-associated lung disease, including asthma, patent numbers US 9,856,283; US 910,526,359; US 11,021,506. J.V.F. is listed as one of the inventors on a filed patent application for lung image-based scoring systems that quantify mucus plug burden in the lung. J.V.F. is a member of the Scientific Advisory Board and receives financial and stock options as compensation for services on the Advisory Board for Suzhou Connect Biopharmaceuticals, Ltd. J.V.F. is a member of the company board and is a consultant for Aer Therapeutics, and receives financial compensation and stocks provided as compensation for services provided. M.A.S. has received speaker fees from the Colorado Allergy and Asthma Society, and is a consultant for Escient Pharmaceuticals. M.A.S. is listed as an inventor on the filed patent application by National Jewish Health, PCT/US24/11470 titled “Methods and Compositions for Treating Mucus Obstruction in Severe Asthma.” S.P.S., M.A.L., N.D.J., E.H.C., M.C.P., M. Chioccioli, C.M.M., B.B.P., N.D., R.P., C.R., M.T.M., C.E., J.R.E., A.C.Y.M., D.H., S.H., S.S., L.F., A.F.M., G.L.Z., C.R.M., J.G., X.Z., V.M., H.W.C., P.C., E.D.G., P.Z., N.R., E.M.D., M.T., E.R.B., S.C.E., D.A.M., M.L.S., J.R.S., C.G.P., and E.G.B. declare no competing interests.
Exploring factors affecting the unsafe behavior of health care workers' in using respiratory masks during COVID-19 pandemic in Iran: a qualitative study.
Exploring factors affecting the unsafe behavior of health care workers' in using respiratory masks during COVID-19 pandemic in Iran: a qualitative study.
Fuente:Bmc Health Services Research
Extracto:
The findings can help
identify and analyze possible scenarios to reduce unsafe behaviors at the time of
using breathing masks. The necessary therapeutic and preventive interventions
regarding the complications of using masks, as well as planning to train
personnel for the correct use of masks with minimal health effects are suggested.
Claves:COVID-19, Health care workers, Pandemic, Respiratory mask
Cita:BMC Health Serv Res 2024 May 9; 24 (1) : 608.
institución:(a) Department of Health in Disasters and Emergencies, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, 1983535511, Iran. (b) Department of Health in Disasters and Emergencies, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, 1983535511, Iran. sohrabizadeh@sbmu.ac.ir.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Relationship between dietary live microbe intake and the prevalence of COPD in adults: a cross-sectional study of NHANES 2013-2018.
Relationship between dietary live microbe intake and the prevalence of COPD in adults: a cross-sectional study of NHANES 2013-2018.
Fuente:Bmc Pulmonary Medicine
Extracto:
A high dietary live microbe intake was associated with a low prevalence of COPD,
and this negative correlation was detected especially in smokers, females,
participants aged from 40 to 59 years old and non-obese participants.
Claves:COPD, Live microbe, NHANES, Prevalence
Cita:BMC Pulm Med 2024 May 9; 24 (1) : 225.
Autor/es:Zhou, Dongbo (a) He, Baimei (b)
institución:(a) Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China. (b) Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cross-Reactive Antibody Responses to Coronaviruses Elicited by SARS-CoV-2 Infection or Vaccination.
Cross-Reactive Antibody Responses to Coronaviruses Elicited by SARS-CoV-2 Infection or Vaccination.
Fuente:Influenza and Other Respiratory Viruses
Extracto:
Our results suggest that SARS-CoV-2 infection or vaccination may
potentially modulate population immune landscape against previously exposed or
novel human coronaviruses. The findings have implications for future
sero-epidemiological studies on MERS-CoV.
Claves:COVID‐19 vaccines, SARS‐CoV‐2, convalescent sera, cross‐reactive antibody, human coronaviruses
Cita:Influenza Other Respir Viruses 2024 May; 18 (5) : e13309.
Autor/es:Lee, Richard S H (a) Cheng, Samuel M S (b)
institución:(a) School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. (b) School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Ambient fine particulate matter and daily mortality: a comparative analysis of observed and estimated exposure in 347 cities.
Ambient fine particulate matter and daily mortality: a comparative analysis of observed and estimated exposure in 347 cities.
Fuente:International Journal of Epidemiology
Extracto:
Mortality risks associated with daily PM2.5
exposure were consistent for both station-observed and model-estimated exposures,
suggesting the reliability and potential applicability of the global PM2.5
product in epidemiological studies.
Claves:Short-term exposure, air monitoring station observation, fine particulate matter, model estimation, mortality risk comparison
Cita:Int J Epidemiol 2024 Apr 11; 53 (3)
Autor/es:Yu, Wenhua (a) Huang, Wenzhong (b)
institución:(a) Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. (b) Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
High-Flow Nasal Cannula Versus Noninvasive Ventilation as Initial Treatment in Acute Hypoxia: A Propensity Score-Matched Study.
High-Flow Nasal Cannula Versus Noninvasive Ventilation as Initial Treatment in Acute Hypoxia: A Propensity Score-Matched Study.
Fuente:Critical Care Explorations
Tipo de trabajo:Estudio de cohortes
Extracto:
AND RELEVANCE: In this
observational study of patients with acute hypoxemic respiratory failure, initial
treatment with NIV compared with HFNC was associated with lower mortality and
fewer composite major pulmonary adverse events calculated using a win ratio.
These findings underscore the need for randomized controlled trials to further
understand the impact of noninvasive respiratory support strategies.
Autor/es:Munroe, Elizabeth S (a) Prevalska, Ina (b)
institución:(a) Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI. (b) Department of Emergency Medicine, University of Michigan, Ann Arbor, MI.
Conflicto:Dr. Munroe was supported by grant number T32 HL 007749 (Multidisciplinary Training Program in Lung Disease), grant number F32 HL 172463 and grant number L30 HL 170379 (Loan Repayment Award) from the National Institutes of Health (NIH) and the National Heart, Lung, and Blood Institute (NHLBI). This work was also supported in part by a grant from NIH (NINDS and...
NHLBI) for infrastructure for the Clinical Coordinating Center for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network—2U24NS100659. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This article does not represent the views of the Department of Veterans Affairs or the U.S. government. Dr. Mosier has received travel support from Fisher & Paykel. The remaining authors have disclosed that they do not have any potential conflicts of interest.
Neuroreceptor Inhibition by Clozapine Triggers Mitohormesis and Metabolic Reprogramming in Human Blood Cells.
Neuroreceptor Inhibition by Clozapine Triggers Mitohormesis and Metabolic Reprogramming in Human Blood Cells.
Fuente:Cells
Extracto:
Since
mitochondrial disturbances are described in the pathophysiology of schizophrenia,
clozapine-induced mitohormesis is an excellent way to escape energy deficits and
improve cell survival.
Autor/es:Fehsel, Karin (a) Bouvier, Marie-Luise (b)
institución:(a) Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Bergische Landstrasse 2, 40629 Duesseldorf, Germany. (b) Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Bergische Landstrasse 2, 40629 Duesseldorf, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Graduate School of Engineering, Yokohama National University, Tokiwadai 79-5, Hodogaya, Yokohama, 240-8501, Japan. (b) Graduate School of Engineering, Yokohama National University, Tokiwadai 79-5, Hodogaya, Yokohama, 240-8501, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Respiratory Support Practices for Bronchiolitis in the Pediatric Intensive Care Unit.
Respiratory Support Practices for Bronchiolitis in the Pediatric Intensive Care Unit.
Fuente:Jama Network Open
Extracto:
AND RELEVANCE: Findings of this
cross-sectional study of patients aged younger than 2 years admitted for
bronchiolitis suggest there was a 3-fold increase in PICU admissions between 2013
and 2022 associated with a 4.8-fold increase in HFNC use and a 5.8-fold increase
in NIV use. Further research is needed to standardize approaches to HFNC and NIV
support in bronchiolitis to reduce resource strain.
Cita:JAMA Netw Open 2024 May 1; 7 (5) : e2410746.
Autor/es:Pelletier, Jonathan H (a) Maholtz, Danielle E (b)
institución:(a) Division of Critical Care Medicine, Department of Pediatrics, Akron Children's Hospital, Akron, Ohio. (b) Department of Pediatrics, Northeast Ohio Medical University College of Medicine, Rootstown, Ohio.
Conflicto:Conflict of Interest Disclosures: Dr Pelletier reported receiving a grant from the Akron Children’s Research Foundation outside the submitted work. Dr Nofziger reported receiving grants from the National Institutes of Health and the Centers for Disease Control and Prevention outside the submitted work. Dr Horvat reported receiving a grant from the Eunice Kennedy Shriver National Institute of Child Health and...
nd Human Development during the conduct of the study. No other disclosures were reported.
Giving a Voice to Patients With Smell Disorders Associated With COVID-19: Cross-Sectional Longitudinal Analysis Using Natural Language Processing of Self-Reports.
Giving a Voice to Patients With Smell Disorders Associated With COVID-19: Cross-Sectional Longitudinal Analysis Using Natural Language Processing of Self-Reports.
Fuente:Jmir Public Health and Surveillance
Extracto:
Our work shows consistent findings with those of previous studies,
which indicate that self-reports, which can easily be extracted online, may offer
valuable information to health care and understanding of smell disorders. At the
same time, our study on self-reports provides new insights for future studies
investigating smell disorders.
Cita:JMIR Public Health Surveill 2024 May 10; 10 : e47064.
Autor/es:Menger, Nick S (a) Tognetti, Arnaud (b)
institución:(a) Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany. (b) Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Applications of Quantitative Microbial Risk Assessment to Respiratory Pathogens and Implications for Uptake in Policy
Applications of Quantitative Microbial Risk Assessment to Respiratory Pathogens and Implications for Uptake in Policy
Fuente:Environmental Health Perspectives
Tipo de trabajo:Revisión
Extracto:
We identified needs
to further the development of QMRA frameworks for respiratory pathogens that
prioritize appropriate aerosol exposure modeling approaches, consider trade-offs
between model validity and complexity, and incorporate research that strengthens
confidence in QMRA results. https://doi.org/10.1289/EHP12695.
Cita:Environ Health Perspect 2024 May; 132 (5) : 56001.
Autor/es:Tang, Lizhan (a) Rhoads, William J (b)
institución:(a) Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland. (b) Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland.
Fetal and Infancy Exposure to Phenols, Parabens, and Phthalates and Anthropometric Measurements up to 36 Months, in the Longitudinal SEPAGES Cohort.
Fetal and Infancy Exposure to Phenols, Parabens, and Phthalates and Anthropometric Measurements up to 36 Months, in the Longitudinal SEPAGES Cohort.
Fuente:Environmental Health Perspectives
Extracto:
This study suggests that exposure in early infancy may be associated
with increased weight and BMI in early childhood, which are risk factors of
obesity in later life. Furthermore, this study highlighted the impact of BPS, a
compound replacing bisphenol A, which has never been studied in this context.
https://doi.org/10.1289/EHP13644.
Cita:Environ Health Perspect 2024 May; 132 (5) : 57002.
Autor/es:Ouidir, Marion (a) Cissé, Aminata H (b)
institución:(a) University Grenoble Alpes, Inserm U-1209, CNRS-UMR-5309, Environmental Epidemiology Applied to Development and Respiratory Health Team, Institute for Advanced Biosciences, Grenoble, France. (b) Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), Paris, France.
Reducing Transmission of Airborne Respiratory Pathogens: A New Beginning as the COVID-19 Emergency Ends.
Reducing Transmission of Airborne Respiratory Pathogens: A New Beginning as the COVID-19 Emergency Ends.
Fuente:Environmental Health Perspectives
Tipo de trabajo:Consenso
Extracto:
https://doi.org/10.1289/EHP13878.
Cita:Environ Health Perspect 2024 May; 132 (5) : 55001.
Autor/es:Marr, Linsey C (a) Samet, Jonathan M (b)
institución:(a) The Charles E. Via, Jr. Department of Civil & Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. (b) Departments of Epidemiology and Environmental and Occupational Health, Colorado School of Public Health, Aurora, Colorado, USA.
Predicting drug-Protein interaction with deep learning framework for molecular graphs and sequences: Potential candidates against SAR-CoV-2.
Predicting drug-Protein interaction with deep learning framework for molecular graphs and sequences: Potential candidates against SAR-CoV-2.
Fuente:Plos One
Extracto:
Finally, we established a 3CLpro-specific
deep learning framework, namely GraphDPI-3CL (AUROC: 0.958) achieved superior
performance beyond the existing state of the art model and discovered 10
molecules with a high binding affinity of 3CLpro and superior binding mode.
Cita:PLoS One 2024; 19 (5) : e0299696.
Autor/es:Du, Weian (a) Zhao, Liang (b)
institución:(a) Department of Dermatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. (b) Shenzhen Health Development Research and Data Management Center, Shenzhen, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
The
literature reviewed suggests that studies on severe pertussis in infants covered
a variety of clinical concerns. However, these studies were observational, and
experimental studies are needed to provide high-quality evidence.
Claves:Pertussis, infants, whooping cough
Cita:Ann Med 2024 Dec; 56 (1) : 2352606.
Autor/es:Guo, Shuai (a) Zhu, Yu (b)
institución:(a) Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. (b) Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Conflicto:No potential conflict of interest was reported by the author(s).