Olvidé mi contraseña
Asóciese a SIIC en Internet para utilizar sin límites tanto siicsalud como la totalidad de los servicios bibliográficos de la institución.
La Sociedad Iberoamericana de Información Científica (SIIC)
selecciona informes completos de calidad recientemente publicados en
fuentes prestigiosas del mundo indizadas por SIIC Data
Bases.
La creciente cantidad de artículos con Acceso Abierto (Open
Access) amplía la oferta de lectura pero a su vez también, entre
tanta abundancia, complica al lector en su encuentro con los estudios
fundamentales. Para facilitarlo, profesionales biomédicos de SIIC
consultan diariamente una profusa cantidad de documentos que nutrirán
Textos completos autorizados (TCA).
Las citas de la sección TCA enlazan de manera legal, autorizada y
gratuita con los textos completos (full text) publicados en
los sitios oficiales de sus respectivas fuentes.
SIIC creó, produjo y opera con exclusividad el software TCA para la
interpretación de los diversos campos documentales que integran la
estructura de un estudio: especialidad, modalidad del estudio,
fuente, fechas de publicación y selección, definición de la fuente,
limitaciones de consulta, resumen en castellano, etc.
Si bien la mayoría de los textos seleccionados corresponden a
artículos originales, revisiones y guías, los lectores también
encontrarán comentarios, entrevistas, notas periodísticas, cartas a
autores u otros textos precursores de debates o aclaratorios.
Sociedad Iberoamericana de Información Científica (SIIC) selects
complete quality-full texts which have been recently published in
renowned sources worldwide and are indexed by SIIC Data
Bases.
The increasing number of Open Access articles widens the reading offer
but, also, such myriad complicates the readers search of fundamental
articles. To facilitate this, SIIC biomedical professionals daily
consult a profuse amount of documents that will feed
Authorized Full Texts (TCA, Spanish acronym).
The citations of the AFT section link legally, authorized and free of
charge with the full texts published in the official web sites of
their corresponding sources.
SIIC created, produced and handles the AFT software that deciphers
the various documentary fields that form part of the structure of a
study: specialty, study style, source, publication and selection
dates, source definition, query limitations, summary in Spanish,
etc.
While most of the selected texts belong to original articles,
reviews, and guidelines, readers will also find commentaries,
interviews, journalistic reports, letters to authors or other texts
that may lead to discussions or clarifications.
Quantification of attenuation and speckle features from endoscopic OCT images for the diagnosis of human brain glioma.
Quantification of attenuation and speckle features from endoscopic OCT images for the diagnosis of human brain glioma.
Fuente:Scientific Reports
Extracto:
The results reveal that it is
reasonable to include the local brightness fluctuations at first two wavelet
decomposition levels in the analysis of OCT brain images aimed at neurosurgical
diagnosis.
Cita:Sci Rep 2024 May 10; 14 (1) : 10722.
Autor/es:Aleksandrova, P V (a) Zaytsev, K I (b)
institución:(a) Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia, 119991. aleksandrovapolina98@gmail.com. (b) Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia, 119991.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Molecular basis of bacterial DSR2 anti-phage defense and viral immune evasion.
Molecular basis of bacterial DSR2 anti-phage defense and viral immune evasion.
Fuente:Nature Communications
Extracto:
Thus, our results provide important insights into the assembly,
activation and inhibition of the DSR2 anti-phage defense system.
Cita:Nat Commun 2024 May 10; 15 (1) : 3954.
Autor/es:Huang, Jiafeng (a) Zhu, Keli (b)
institución:(a) Key Laboratory of Molecular Medicine and Biotherapy, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. jfhuang@ibp.ac.cn. (b) Key Laboratory of Biomacromolecules (CAS), National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. jfhuang@ibp.ac.cn.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Consensus-building conversation leads to neural alignment.
Consensus-building conversation leads to neural alignment.
Fuente:Nature Communications
Extracto:
Socially central participants were also more likely to become neurally
aligned to others in their groups.
Cita:Nat Commun 2024 May 10; 15 (1) : 3936.
Autor/es:Sievers, Beau (a) Welker, Christopher (b)
institución:(a) Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, 03755, USA. beau@beausievers.com. (b) Department of Psychology, Stanford University, Stanford, CA, 94305, USA. beau@beausievers.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Regional nigral neuromelanin degeneration in asymptomatic leucine-rich repeat kinase 2 gene carrier using MRI.
Regional nigral neuromelanin degeneration in asymptomatic leucine-rich repeat kinase 2 gene carrier using MRI.
Fuente:Scientific Reports
Extracto:
Asymptomatic LRRK2 carriers showed globally
decreased SNc volume and CNR suggesting early nigral neurodegeneration in these
subjects at risk of developing PD.
institución:(a) Department of General Practice, Tianjin Union Medical Center, Tianjin, China. (b) Paris Brain Institute - ICM, INSERM U1127, CNRS UMR 7225, Pitié-Salpêtrière Hospital, Sorbonne Université, Paris, France. rahul.gaurav@icm-institute.org.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder.
Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder.
Fuente:Communications Biology
Extracto:
These results revealed previously unknown metabolic phenotypes, identified new
developmental states of the metabolic correlation network, and underscored the
role of mitochondrial functional changes, purine metabolism, and purinergic
signaling in autism spectrum disorder.
Cita:Commun Biol 2024 May 10; 7 (1) : 536.
Autor/es:Lingampelly, Sai Sachin (a) Naviaux, Jane C (b)
institución:(a) The Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA, 92103-8467, USA. (b) Department of Medicine, University of California, San Diego School of Medicine, San Diego, CA, 92103-8467, USA.
Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus.
Sex affects transcriptional associations with schizophrenia across the dorsolateral prefrontal cortex, hippocampus, and caudate nucleus.
Fuente:Nature Communications
Extracto:
These findings emphasize the importance of sex-informed analysis of
sexually dimorphic traits, inform personalized therapeutic strategies in
schizophrenia, and highlight the need for increased female samples for
schizophrenia analyses.
Cita:Nat Commun 2024 May 10; 15 (1) : 3980.
Autor/es:Benjamin, Kynon J M (a) Arora, Ria (b)
institución:(a) Lieber Institute for Brain Development, Baltimore, MD, USA. KynonJade.Benjamin@libd.org. (b) Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. KynonJade.Benjamin@libd.org.
Conflicto:D.R.W. serves on the Scientific Advisory Boards of Sage Therapeutics and Pasithea Therapeutics. J.E.K. is a member of a drug monitoring committee for an antipsychotic drug trial for Merck. All other authors declare no competing interests.
Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase.
Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase.
Fuente:Nature Communications
Extracto:
Moreover, the introduction of p.R841H in wild type cells reduced such
immunity, suggesting that this mutation is linked to the observed phenotypes.
institución:(a) Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland. (b) Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) School of Medicine, Shanghai Jiao Tong University, No.227 Chongqing Rd (S), Shanghai, China. (b) Department of neurology, Xinhua Hospital, Shanghai Jiao tong University School of Medicine, No.1665 Kongjiang Rd, Shanghai, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Development, validation and application of single molecule molecular inversion probe based novel integrated genetic screening method for 29 common lysosomal storage disorders in India.
Development, validation and application of single molecule molecular inversion probe based novel integrated genetic screening method for 29 common lysosomal storage disorders in India.
Fuente:Human Genomics
Extracto:
We developed a flexible and scalable
assay to reliably detect genetic causes of 29 common LSDs in India. The assay
consolidates the detection of multiple variant types in multiple sample types
while having improved diagnostic yield at same or lower cost compared to current
clinical paradigm.
institución:(a) FRIGE Institute of Human Genetics, FRIGE House, Jodhpur Village Road, Satellite, Ahmedabad, India, 380015. harsh.sheth@frige.co.in. (b) FRIGE Institute of Human Genetics, FRIGE House, Jodhpur Village Road, Satellite, Ahmedabad, India, 380015.
Conflicto:Harsh Sheth, Aadhira Nair and Jayesh Sheth are named as inventors on the patent describing the use of smMIP based target capture and associated computational analyses for simultaneous detection of single nucleotide variants and copy number variants in germline DNA. The patent is held by FRIGE’s Institute of Human Genetics (Patent ID: TEMP/E-1/30548/2022-MUM, submitted in May 2022). All other authors...
rs declare that they have no conflict of interest.
Cita:J Health Popul Nutr 2024 May 10; 43 (1) : 62.
Autor/es:Miao, Chuhan (a) Lu, Qingyang (b)
institución:(a) School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, No.5 Sassoon Road, Pokfulam, Hong Kong SAR, China. (b) School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, No.5 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Conflicto:We declare that there is no competing conflict of interest.
Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer's Disease Biomarkers: A Comparison of the Lumipulse and Simoa Platforms.
Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer's Disease Biomarkers: A Comparison of the Lumipulse and Simoa Platforms.
Fuente:International Journal of Molecular Sciences
Extracto:
At present, the analysed AD
plasma biomarkers may be useful for screening to reduce the number of lumbar
punctures in the clinical setting.
institución:(a) Cognitive Disorders Unit, Cognition and Behaviour Study Group, Santa Maria University Hospital, IRBLleida, 25198 Lleida, Spain. (b) Achucarro Basque Center for Neuroscience, 48940 Leioa, Spain.
Conflicto:The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.
HLA-DR Expression in Natural Killer Cells Marks Distinct Functional States, Depending on Cell Differentiation Stage.
HLA-DR Expression in Natural Killer Cells Marks Distinct Functional States, Depending on Cell Differentiation Stage.
Fuente:International Journal of Molecular Sciences
Extracto:
The obtained results broaden the knowledge about
HLA-DR-positive NK cell appearance, diversity, and functions, which might be
useful in terms of understanding the role of this subset in innate immunity and
assessing their possible implications in NK cell-based therapy.
Autor/es:Kust, Sofya A (a) Ustiuzhanina, Maria O (b)
institución:(a) Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia. (b) Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Revealing Genetic Dynamics: scRNA-seq Unravels Modifications in Human PDL Cells across In Vivo and In Vitro Environments.
Revealing Genetic Dynamics: scRNA-seq Unravels Modifications in Human PDL Cells across In Vivo and In Vitro Environments.
Fuente:International Journal of Molecular Sciences
Extracto:
These discoveries not only deepen our comprehension of PDL biology but
also open avenues for future investigations into uncovering underlying
mechanisms.
institución:(a) Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany. (b) Institute of Medical Statistics and Computational Biology, Faculty of Medicine, University of Cologne, 50923 Cologne, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Mitochondrial DNA and Electron Transport Chain Protein Levels Are Altered in Peripheral Nerve Tissues from Donors with HIV Sensory Neuropathy: A Pilot Study.
Mitochondrial DNA and Electron Transport Chain Protein Levels Are Altered in Peripheral Nerve Tissues from Donors with HIV Sensory Neuropathy: A Pilot Study.
Fuente:International Journal of Molecular Sciences
Extracto:
Identifying molecules to safeguard mitochondrial integrity could aid in treating
or preventing HIV-associated peripheral neuropathy.
Claves:DSP, common deletion mutation, distal symmetric polyneuropathy, mtDNA
Cita:Int J Mol Sci 2024 Apr 26; 25 (9)
Autor/es:Boustani, Ali (a) Kulbe, Jacqueline R (b)
institución:(a) Department of Psychiatry, University of California San Diego, San Diego, CA 92093, USA. (b) Department of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study.
Hydroxytyrosol, a Promising Supplement in the Management of Human Stroke: An Exploratory Study.
Fuente:International Journal of Molecular Sciences
Extracto:
Although a larger trial is necessary, this study suggests that HT could
be a beneficial nutritional complement in the management of human stroke.
Autor/es:Naranjo, Ángela (a) Álvarez-Soria, M Josefa (b)
institución:(a) Departamento de Biología Experimental, Universidad de Jaén, 23071 Jaén, Spain. (b) Servicio de Neurología, Hospital Universitario de Jaén, 23009 Jaén, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The Role of Structural Variants in the Genetic Architecture of Parkinson's Disease.
The Role of Structural Variants in the Genetic Architecture of Parkinson's Disease.
Fuente:International Journal of Molecular Sciences
Extracto:
This review aims to provide a comprehensive
overview of our current understanding of the involvement of coding and noncoding
SVs in the genetic architecture of PD.
institución:(a) Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA. (b) Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD 20892, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy. (b) Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracellular Vesicles in Environmental Toxicological Studies: Association between Urinary Concentrations of Phthalate Metabolites and Exosomal miRNA Expression Profiles.
Extracellular Vesicles in Environmental Toxicological Studies: Association between Urinary Concentrations of Phthalate Metabolites and Exosomal miRNA Expression Profiles.
Fuente:International Journal of Molecular Sciences
Extracto:
In summary, the obtained results demonstrate that exposure
to environmental phthalates could be related to altered expression profiles of
specific ELV-miRs in adult men, thereby demonstrating the potential of miRs
carried by exosomes to act as early effect biomarkers.
institución:(a) School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy. (b) Dipartimento di Neuroscienze, Imaging e Scienze Cliniche, University "G. d'Annunzio" of Chieti, 66100 Chieti, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Tobacco Smoke Condensate Induces Morphologic Changes in Human Papillomavirus-Positive Cervical Epithelial Cells Consistent with Epithelial to Mesenchymal Transition (EMT) with Activation of Receptor Tyrosine Kinases and Regulation of TGFB.
Tobacco Smoke Condensate Induces Morphologic Changes in Human Papillomavirus-Positive Cervical Epithelial Cells Consistent with Epithelial to Mesenchymal Transition (EMT) with Activation of Receptor Tyrosine Kinases and Regulation of TGFB.
Fuente:International Journal of Molecular Sciences
Extracto:
Understanding the molecular pathways and environmental
factors that initiate EMT in ectocervical cells will help delineate molecular
targets for intervention and define the role of EMT in the initiation and
progression of cervical intraepithelial neoplasia and CC.
Claves:cervical cancer (CC), cigarette smoke condensate (CSC), epithelial to mesenchymal transition (EMT), high-risk human papillomavirus (HR-HPV), receptor tyrosine kinase (RTK), transforming growth factor-beta (TGFB)
Cita:Int J Mol Sci 2024 Apr 30; 25 (9)
Autor/es:Mark, Zaniya A (a) Yu, Linda (b)
institución:(a) Department of Biochemistry, Cancer Biology, Neuroscience, and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA. (b) Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
D-Bifunctional Protein Deficiency Diagnosis-A Challenge in Low Resource Settings
D-Bifunctional Protein Deficiency Diagnosis-A Challenge in Low Resource Settings
Fuente:International Journal of Molecular Sciences
Tipo de trabajo:Revisión
Extracto:
We advocate for
using molecular diagnosis in critically ill newborns and infants to improve care,
reduce healthcare costs, and allow for familial counseling.