Se presenta un caso clínico de tuberculosis pulmonar y extrapulmonar cuya presentación clínica fue similar a la del síndrome SAPHO. Se destaca la necesidad de incluir a la tuberculosis como un diagnóstico diferencial de esta afección, en especial en los pacientes procedentes de áreas endémicas.
Uwe Wollina
Columnista Experto de SIIC
Institución del autor
Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Alemania
L Unger* S Wollschläger* M Prinz* T Kittner*   
Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Alemania*

Palabras clave
síndrome SAPHO, pesquisa de tuberculosis, tuberculosis

Clasificación en siicsalud
Artículos originales > Expertos del Mundo >

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Primera edición
5 de agosto, 2011
Segunda edición, ampliada y corregida
7 de junio, 2021

Bibliografía del caso clínico
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2. Sallés M, Olivé A, Perez-Andres R, et al. The SAPHO syndrome: a clinical and imaging study. Clin Rheumatol 2010; in press.
3. Coloe J, Diamantis S, Henderson F, Morrell DS. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome complicated by seven pulmonary emboli in a 15-year old patient. J Am Acad Dermatol 2010; 62: 333-6.
4. Clina M, Govoni M, Orzincolo C, Trotta F. Clinical and radiologic evaluation of sinoviti, acne, pustulosis, hyperostosis, and osteitis syndrome: a single center study of a cohort of 71 subjects. Arthritis Rheum 2009; 61: 813-21.
5. Grosjean C, Hurtado-Nedelec M, Nicaise-Roland P, et al. Prevalence of autoantibodies in SAPHO syndrome: a single-center study of 90 patients. J Rheumatol 2010; 37: 639-43.
6. Hurtado-Nemelec M, Chollet-Martin S, Chapeton D, et al. Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes. J Rheumatol 2010; 37: 401-9.
7. Arnson Y, Rubinow A, Amital H. Secondary syphilis presenting as SAPHO syndrome features. Clin Exp Rheumatol 2008; 26: 1119-21.
8. Hurtado-Nemelec M, Chollet-Martin S, Nicaise-Roland P, et al. Characterization of the immune response in the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. Rheumatology (Oxford) 2008; 47: 1160-7.
9. Guglielmi G, Cascavilla A, Scalzo G, et al. Imaging of sternocostoclavicular joint in spondyloarthropathies and other rheumatic conditions. Clin Exp Rheumatol 2009; 27: 402-8.
10. Huber CE, Judex AG, Freyschmidt J, et al. Sequential combination therapy leading to sustained remission in a patient with SAPHO syndrome. Open Rheumatol J 2009; 3: 18-21.
11. Ben Abdelghani K, Dran DG, Gottenberg JE, et al. Tumor necrosis factor-alpha blockers in SAPHO syndrome. J Rheumatol 2010; 37: 1699-704.
12. Khan SA, Zahid M, Asif N, Hassan AS. Tuberculosis of the sternoclavicular joint. Indian J Chest Dis Allied Sci 2002; 44: 271-3.
13. Dhillon MS, Gupta RK, Bahadur R, Nagi ON. Tuberculosis of the sternoclavicular joints. Acta Orthop Scand 2001;72:514-7.
14. Bezza A, Niamane R, Benbouazza K, et al. Tuberculosis of the sternoclavicular joint. Report of two cases. Rev Rhum Engl Ed 1998; 65: 791-4.
15. Shah J, Patkar D, Parikh B, et al. Tuberculosis of the sternum and clavicle: imaging findings in 15 patients. Skeletal Radiol 2000; 29: 447-53.
16. Sonozaki H, Azuma A, Okai K, et al. Clinical features of 22 cases with "inter-sterno-costo-clavicular ossification". A new rheumatic syndrome. Arch Orthop Trauma Surg 1979; 95:13-22.
17. Nakamura J, Yamada K, Mitsugi N, Saito T. A case of SAPHO syndrome with destructive spondylodiscitis suspicious of tuberculous spondylitis. Mod Rheumatol 2010; 20:93-7.
18. Wallis RS. Infectious complications of tumor necrosis factor blockade. Curr Opin Infect Dis 2009; 22: 403-9.
19. Bøhler M, Mustafaa SA, Mørkve O. Tuberculosis treatment outcome and health services: a comparison of displaced and settled population groups in Khartoum, Sudan. Int J Tuberc Lung Dis 2005; 9: 32-6.
Artículos publicados por el autor (selección)
Wollina U Rosacea and rhinophyma in the elderly Clinics Dermatol 29:61-68, 2011

Wollina U, Haroske G Pyoderma gangrenosum Curr Opin Rheumatol 23:50-56, 2011

Hansel G, Schönlebe J, Haroske G, Wollina U Late recurrence (10 years or more) of malignant melanoma in south-east Germany (Saxony). A single-centre analysis of 1,881 patients with a follow-up of 10 years or more J Eur Acad Dermatol Venereol 24:833-836, 2010

Solís D, Maté MJ, Lohr M, Ribeiro J, López-Merino L, André S, Buzament E, Cañada FJ, Kaltner y col. N-Domain of human adhesion/growth-regulatory galectin-9, a monomeric protein with characteristic localization in colon cancer and melanoma: selectivity for ligand conformers/type of cell surface glycoconjugate and detection of ligand-induced structural changes in crystal and in solution Int J Biochem Cell Biol 42:1019-1029, 2010

Verma SB, Wollina U Acne keloidalis nuchae: more than a casual association with metabolic syndrome, truncal obesity and impending/overt diabetes? Am J Clin Dermatol 11:433-436, 2010

Wollina U Pompholyx. A review of clinical features, differential diagnosis and management. Am J Clin Dermatol 11:305-314, 2010

Wollina U Bilateral milia en plaque of the eyelids, long eyelashes and unibrow - case report and review of literature. Dermatol Surg 36:406-408, 2010

Wollina U Ablative erbium:YAG laser treatment of idiopathic chronic inflammatory non-cicatrical balanoposthitis (Zoon's disease) - a series of 20 patients with long-term outcome. J Cosm Laser Ther 12:120-123, 2010

Wollina U Riga-Feede-like disease in a 70-year-old woman - case report and treatment. Indian J Dermatol 55:92-94, 2010

Wollina U, Bayyoud Y Reconstruction of a large scalp defect by sequential use of dermal substitute, self-filling osmotic tissue expander and rotational flap. J Cutan Aesth Surg 3:106-110, 2010

Wollina U, Goldman A, Heinig B Microcannular tumescent liposuction in advanced lipoedema and Dercum's disease. G Ital Dermatol Venereol 145:151-159, 2010

Wollina U, Hansel G, Krönert C, Heinig B Using VAC to facilitate healing of traumatic wounds in patients with chronic lymphoedema. J Wound Care 19:15-17, 2010

Wollina U, Pabst F, Krönert C, Schorcht J, Haroske G, Kittner T High-risk basal cell carcinoma: an update. Expert Rev Dermatol 5:357-368, 2010

Wollina U, Payne CR Aging well - the role of minimally invasive aesthetic dermatological procedures in women over 65. J Cosmet Dermatol 9:50-58, 2010

Wollina U, Unger L, Heinig B, Kittner T Psoriatic arthritis. Dermatol Ther 23:123-136, 2010

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