Authors' Reports

Gabriela Adriana Filip
describes for SIIC the most significant aspects of her article
describe para SIIC los aspectos relevantes de su artículo

Modulation of Dox–induced toxicity and chemoprotective effects by GSE

Grape seeds extract, Vitis vinifera L., variety Burgund Mare might be a chemoprotective candidate in reducing the oxidative stress and the risk for UV-induced cancer and recommend its use as such or in combination with sunscreens and/or other natural products with similar or complementary properties.

The article was published by
El artículo fue publicado por
Journal of Medicinal Food
Volume / Volumen: 15
Number / Número: 7
First and last pages / Páginas inicial-final: 639-645
Year / Año: 2012
Month / Mes: july

Principal institution where the research took place
Institución principal de la investigación
Department of Radiobiology and Tumor Biology, „Prof. I. Chiricuta” Oncologic Institute, Cluj Napoca, Cluj, Romania

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

Chis IC, Ungureanu MI, Marton A, Simedrea R, Muresan A, Postescu ID. Antioxidant effects of a grape seed extract in a rat model of diabetes mellitus. Diabetes Vasc Dis Res 6(3):200-204, 2009.
Dicu T, Postescu ID, Tatomir C, M. Tămaş, Cosma C. A novel method to calculate the antioxidant parameters of redox reaction between the polyphenolic compounds and stable DPPH radical. Ital J Food Sci Rev 22(3):333-339, 2010.
Dicu T, Postescu ID, V Foriş, Brie I, Fischer-Fodor E, Moldovan M, Cosma C. The effect of a grape seed extract on radiation-induced DNA damage in human lymphocytes. Amer Inst Phys Conf Proceed 1131:181-187, 2009.
Filip A, Clichici S, Daicoviciu D, Catoi C, Bolfa P, Tatomir C, Baldea I, Gherman C, Postescu ID, Muresan A. Chemopreventive effects of Vitis Vinifera and Calluna Vulgaris extracts on UVB-induced skin damage in SKH-1 hairless mice. J. Physiol. Pharmacol. 62(3):383-392, 2011.
Filip A, Daicoviciu D, Clichici S, Bolfa P, Catoi C, Baldea I, Bolojan L, Olteanu D, Muresan A, Postescu ID. The effects of grape seeds polyphenols on SKH-1 mice skin irradiated with multiple doses of UV-B. Photochem Photobil Biol B: Biology 105:133-142, 2011.
Filip A, Daicoviciu D, Clichici S, Mocan T, Muresan A, Postescu ID. Photoprotective effects of two natural products on UVB-induced oxidative stress and apoptosis in SKH-1 mice skin. J Med Food 14(7-8):761-766, 2011.
Perde-Schrepler M, Chereches G, Brie I, Tatomir C, Postescu ID, Soran L, Filip A. Grape seed extract as photochemopreventive agent against UVB-induced skin cancer. J Photochem Photobiol (in press).
Postescu ID, Chereches G, Tatomir C, Daicoviciu D, Filip A. Modulation of Doxorubicin Induced Oxidative Stress by a Grape (Vitis Vinifera L.) Seed Extract in Normal and Tumor Cells. J Med Food 15:639-645, 2012.
Postescu ID, Tatomir C, Chereches G, Brie I, Damian G, Petrisor D, Hosu AM, Pop N. Spectroscopic characterisation of grape extracts with potential role in tumor growth inhibition. J Optoel Adv Mater (JOAM) 9(3):564-567, 2007.
Postescu ID, Virag P, Achim M, Fischer-Fodor E. Influence of palm oil on doxorubicin induced cytotoxicity in normal and tumor cell cultures. Phytother Res 24(1):154-156, 2010.
Sabau L, Damian G, Daicoviciu D, Muresan A, Postescu ID, Mihu D, Mihu C. In vivo study regarding antioxidant effect of a grape polyphenol extract using biochemical and FTIR methods. J Optoel Adv Mater (JOAM) 2(1):44-49, 2010.
Suciu S, Postescu ID, Muresan A, Virag P, Daicoviciu D, Fischer-Fodor E. In vitro and in vivo studies on the modulatory effects of a grape (Vitis vinifera) seed extract in normal and tumor cells. J Clin Biochem Nutr 43(Suppl.1):493-496, 2008.

Other articles written by the author Gabriela Adriana Filip
Otros artículos de Gabriela Adriana Filip

SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Gabriela Adriana Filip was invited by SIIC on
Gabriela Adriana Filip fue invitado por SIIC el
2012, august 8
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Bioquímica
/ Oncología

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Anatomía Patológica

Molecular Biology
Biología Molecular

Toxicological Biochemistry
Bioquímica Toxicológica

Biological Chemistry
Química Biológica

Immunological Biochemistry
Bioquímica Inmunológica


Basic Pharmacology
Farmacología Básica

Information about the full text
Acerca del trabajo completo

Modulation of Doxorubicin-Induced Oxidative Stress By a Grape (Vitis Vinifera L.) Seed Extract in Normal and Tumor Cells

Author / Autor
Gabriela Adriana Filip1, Ion Dan Postescu2, Maria Perde Schrepler3, Gabriela Adriana Filip4

4 Associate Professor, Department Of Physiology, „iuliu Hatieganu” University Of Medicine And Pharmacy

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Journal of Medicinal Food

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