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Flavia Frattini
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

The influence of mesenchymal stem cells on peripheral nerve repair

Peripheral nerve injury was restored after implant of mesenchymal stem cells into a biodegradable tube. The nerve regenerated and the sensory neurons were preserved from dying, leading to an improvement on the motor function of affected mice. Use of these stem cells might be a promising strategy for nervous system lesions.

The article was published by
El artículo fue publicado por
Tissue Engineering: Part A
Volume / Volumen: 18
Number / Número: 19-20
First and last pages / Páginas inicial-final: 2030-2039
Year / Año: 2012
Month / Mes: october

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Programa de Pesquisa em Neurociência Básica e Clínica, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Rio de Janeiro, Rio de Janeiro, Brazil

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

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CampbellWW. Evaluation and management of peripheral nerve injury. Clinical Neurophysiology 119:1951, 2008.
Chen C, Ou YC, Liao SL, Chen WY, Chen SY, Wu CW, et al. Transplantation of bone marrow stromal cells for peripheral nerve repair. Exp Neurol 204:443, 2007.
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Jivan S, Novikova LN, Wiberg M, Novikov LN. The effects of delayed nerve repair on neuronal survival and axonal regeneration after seventh cervical spinal nerve axotomy in adult rats. Exp Brain Res 170:245, 2006.
Ladak A, Olson J, Tredget EE, Gordon T. Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model. Exp Neurol 228:242, 2011.
Lohmeyer JA. and Machens, H. Basics and current approaches to tissue engineering in peripheral nerve reconstruction. Neurosurgery Q 19:101, 2009.
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Pan HC, Cheng FC, Chen CJ, Lai SZ, Lee CW, Yang DY, et al. Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells. J Clin Neurosci 14:1089, 2007.
Pereira Lopes FR, Frattini F, Marques SA, Almeida FM, Moura Campos LC, Langone F, et al. Transplantation of bone-marrow derived cells into a nerve guide resulted in transdifferentiation into Schwann cells and effective regeneration of transected mouse sciatic nerve. Micron 41:783, 2010.
Pereira Lopes FR, Moura Campos LC, Correa JD Jr, Balduno A, Lora S, Langone F, et al. Bone marrow stromal cells and resorbable collagen guidance tubes enhance sciatic nerve regeneration in mice. Exp Neurol 198:457, 2006.
Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, et al. Adult bone
Wang J, Ding F, Gu Y, Liu J, Gu X. Bone marrow mesenchymal stem cells promote cell proliferation and neurotrophic function of Schwann cells in vitro and in vivo. Brain Res 1262:7, 2009.
Wang X, Luo E, Li Y, Hu J. Schwann-like mesenchymal stem cells within vein graft facilitate facial nerve regeneration and remyelination. Brain Res 1383:71, 2011.

Other articles written by the author Flavia Frattini
Otros artículos de Flavia Frattini

Pereira Lopes, F.R., Frattini, F., Marques, S.A., Almeida, F.M., Moura Campos, L.C., Langone, F., Lora, S., Borojevic, R., and Martinez, A.M. Transplantation of bone-marrow derived cells into a nerve guide resulted in transdifferentiation into Schwann cells and effective regeneration of transected mouse sciatic nerve. Micron 41, 783, 2010.

Pereira Lopes FR, Lisboa BC, Frattini F, Almeida FM, Tomaz MA, Matsumoto PK, Langone F, Lora S, Melo PA, Borojevic R, Han SW, Martinez AM. Enhancement of sciatic nerve regeneration after vascular endothelial growth factor (VEGF) gene therapy. Neuropathol Appl Neurobiol,37(6),600, 2011.

Pereira Lopes FR, Martin PK, Frattini F, Biancalana A, Almeida FM, Tomaz MA, Melo PA, Borojevic R, Han SW, Martinez AM.Double gene therapy with granulocyte colony-stimulating factor and vascular endothelial growth factor acts synergistically to improve nerve regeneration and functional outcome after sciatic nerve injury in mice. Neuroscience, 29(230), 184, 2013.

SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Flavia Frattini was invited by SIIC on
Flavia Frattini fue invitado por SIIC el
2013, january 16
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Anatomía Patológica
/ Neurología

and secondarily related to the following sections

y secundariamente con las siguientes secciones




Information about the full text
Acerca del trabajo completo

Mesenchymal Stem Cells in a Polycaprolactone Conduit Promote Sciatic Nerve Regeneration and Sensory Neuron Survival After Nerve Injury

Author / Autor
Flavia Frattini1, Fatima Rosalina Pereira Lopes2, Fernanda Martins Almeida3, Rafaela Fintelman4, Leonardo Cunha Boldrini5, Marcelo A. Tomaz6, Abrahao Fontes Baptista7, Paulo A. Melo8, Ana Maria Blanco Martinez9

9 Md, Phd, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brasil

Access to the original source
Tissue Engineering: Part A

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