Sujata Kar describes for SIIC the most significant aspects of his article describe para SIIC los aspectos relevantes de su artículo Ovulation induction in PCOS. OVULATION INDUCTION DRUG IN INFERTILE PCOS WOMEN: A PROSPECTIVE RANDOMIZED TRIAL Clomiphene citrate is an excellent, time tested drug for ovulation induction in infertile PCOS women. However, letrozole is showing promise as a better or at-par drug for the purpose. Our study shows a three fold higher pregnancy rate , and a very high mono follicular rate with letrozole when compared to clomiphene citrate. The article was published by El artículo fue publicado por
Principal institution where the research took place Institución principal de la investigación Kar clinic & hospital Pvt. Ltd, Bhubaneswar, Odisha, India Authors' Report Crónica del Autor Bibliographic references Referencias bibliográficas Kovacs G, Wood C. The current status of polycystic ovary syndrome. Aust NZ J Obstet Gynecol 41:65-68, 2001. Guzick D. Polycystic ovary syndrome, symptolatology pathophysiology and epidemiology. Am J Obstet Gynecol 179:89-93, 1998. Slowey MJ. Polycystic ovary syndrome: new perspective on an old problem. South Med J 94:190-195, 2001. Casper RF. Letrozole versus clomiphene citrate: which is better for ovulation induction? Fertility and Sterility 92(3):858-859, 2009. Amsterdam ESHRE/ASRM - Sponsored 3rd PCOS consensus workshop Group consensus on women's health aspects of polycystic ovary syndrome Hum & Reprod 27(1):14-24, 2012. Franks S, Adams J, Mason H, Polson D. Ovulatory disorders in women with polycystic ovary syndrome. Clin Obstet Gynecol 12:605-632, 1985. Kistner RW. Induction of ovulation with clomiphene citrate (clomid). Obstet Gynecol Survey 20:873-900, 1965. Mitwally MFM, Casper RF. Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. Fertil Steril 75:305-9, 2001. Wessman A, McArdle CR, Achiron R. Ultrasound in infertility. In: Machelle M, Seibel MD, eds. Infertility-a comprehensive text. 2nd ed. Stamford, CT: Appleton & Lange, pp. 447-92, 1996. Sammour A, Biljan MM, Tan SL, Tulandi T. Prospective randomized trial comparing the effects of letrozole and clomiphene citrate (CC) on follicular development, endometrial thickness and pregnancy rate in patients undergoing superovulation prior to intrauterine insemination. 57th Annual Meeting of the American Society for Reproductive Medicine, Orlando, FL, October 20-25, 2001. Ganesh A, Goswami SK, Chattopadhyay R, Choudhury K, Chakravarty BN. Comparison of letroz with continuous gonadotropins and clomiphene gonadotropin combination for ovulation induction. In 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial. J Assist Reprod Genet Jan 26:19-24, 2009. Pandit K, Goswami S, Ghoshs, Mukhopadhyay P, Chowdhury S. Insulin resistance in metabolic syndrome in Indian PCOS South Asians. Indian J Endocrinal Metab 16(1);44-55, 2012. Gonen Y, Casper RF. Sonographic determination of a possible adverse effect of clomiphene citrate on endometrial growth. Hum Reprod 5:670-674, 1990. Yagel S, Ben-Chetrit A, Anteby E, Zacut D, Hochner-Celnikier D, Ron M. The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by clomiphene citrate. Fertil Steril 57:33-36, 1992. Dickey RP, Olar TT, Taylor SN, Curole DN, Matulich EM. Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin. Fertil Steril 59:756-760, 1993. Opsahl MS, Robins ED, O'Connor DM, Scott RT, Fritz MA. Characteristics of gonadotropin response, follicular development, and endometrial growth and maturation across consecutive cycles of clomiphene citrate treatment. Fertil Steril 66:533-539, 1996. Eden JA, Place J, Carter GD, Jones J, Alaghband-Zadeh J, Pawson ME. The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume. Obstet Gynecol 73:187-190, 1989. Weil SJ, Vendola K, Zhou J, Adesanya OO, Wang J, Okafor J, et al. Aandrogen receptor controlled ovarian hyperstimulation in the primate ovary: cellular localization, regulation, and functional correlation. J Clin Endocrinol Metab 83:2479-85, 1998. Weil SJ, Vendola K, Zhou J, Bondy CA. Androgen and follicle stimulating hormone interactions in primate ovarian follicle development. J Clin Endocrinol Metab 84:2951-6, 1999. Vendola K, Zhou J, Wang J, Famuyiwa OA, Bienre M, Bondy CA. Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary. Biol Reprod 61:353-7, 1999. Vendola KA, Zhou J, Adesanya OO, Weil SJ, Bondy CA. Androgen stimulate early stages of follicular growth in the primate ovary, J Clin Invest 101:2622-9, 1998. Glintborg D, Menriksen JE, Andresen M, Hagen C, Hangaard J. etal. Prevalence of endocrine diseases and abnormal glucose tolerance tests in 340 cavcasian premenopausal women with hirsutism as referral diagnosis. Feral Steral 84:1570-1579, 2004. Badawg A, Aal IA, Abulalta M. Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome, a prospective randomized trial Fertal Steril 92(3):849-852. Bayar U, Tanriverdi HA, Aykut B, Ayoglu F, Ozcan O, Erdal K. Letrozole Vs clomiphene citrate in patients with ovulatory infertility, Fertil Steril 85:1045-1048, 2006. Zeinalzadeh M, Basirat Z, Esmalpour M. Efficacy of letrozole in ovulation indication. compared to that of clomiphene citrate in patients with polycystic ovarian syndrome. J Reprod Med 55:36-40, 2010. Mitwally M, Casper R. Use of aromatase inhibitor for ovulation induction in patients with an inadequate response to clomiphene citrate. Fertil Steril 75:305-309, 2001. Cortinez I, De Carvaiho D, Vantman F, Gabler G, Iniguez R, Vega M. Hormonal profile and endometrial morphology in letrozole-controlled ovarian hyperstimulation in ovulatory infertile patients. Fertil Steril 83:110-115, 2005. Fisher SA, Reid RL, Van Vugt DA, Casper RF. A randomized souble-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor on ovulatory function in normal women. Fertil Steril 78:280-285, 2002. Kilic-Okman T, Kucuk M, Altaner S. Comparison of the effects of letrozole and clomiphene sitrate on ovarian follicles, endometrium, and hormone levels in the rat. Fertil Steril 80:1330-1332, 2003. Banerjee Ray P, Ray A, Chakroborti PS. Comparison of efficacy of letrozole and clomiphene citrate in ovulation induction in Indian women with polycystic ovarian syndrome. Arch Gynecol Obstet 285(3):873-877, 2012. He D, Jiang F. Meta analysis of letrozole versus clomiphene citrate in polycystic ovary syndrome. Reprod Biomed on Line 23(1):91-96, 2011. Begum MR, Ferdous J. Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome. Fertil Steril 92(3):853-857, 2009. SIIC System of Assisted Editing (SSEA) / Sistema SIIC de Edición Asistida (SSEA)
The article is strictly related to the following sections of siicsalud El artículo se relaciona estrictamente con las siguientes secciones de siicsalud
Information about the full text Acerca del trabajo completo Clomiphene Citrate or Letrozole as First-Line Ovulation Induction Drug in Infertile PCOS Women: A Prospective Randomized Trial Author / Autor Sujata Kar1 1 Dr, Kar Clinic & Hospital Pvt. Ltd, Bhubaneswar, India, Consultant Access to the original source Journal of Human Reproductive Sciences siic DB: / siic DB: http://www.siicsalud.com/main/distriprinrel.php |