DIFFERENTIAL DIAGNOSIS OF LUNG CARCINOMA WITH LABEL-FREE IMAGING

Authors' Reports

Stephen Wong
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DIFFERENTIAL DIAGNOSIS OF LUNG CARCINOMA WITH LABEL-FREE IMAGING

This report describes a new class of endomicroscopy that combines chemical selective molecular vibrational imaging techniques, such as coherent anti-Stokes Raman scattering (CARS) imaging, with fiber optic delivery and quantitative analytics for obtaining histology-like images from inside the human body in real-time with no label. Endomicroscopes generally can achieve a resolution on the order of a µm and have a field-of-view of several hundred µm. Current endomicroscope products, however, often require fluorophores, which are excitable using laser lights, and limit their applications in clinics. The objective of the proposed label-free endomicroscope is to sidestep the use of flourophores by visualizing morphological patterns and detecting intrinsic biomarkers of cells and tissues via high-speed, chemical selective CARS imaging. The label-free endomicroscope is developed to post-process and characterize CARS images and provide diagnostic information using disease-related features and classification. The prototype device has shown high accuracy and specificity for differential lung cancer diagnosis and thus demonstrated its potential for clinical translations.

The article was published by
El artículo fue publicado por

Archives of Pathology & Laboratory Medicine
Volume / Volumen: 136
Number / Número: 12
First and last pages / Páginas inicial-final: 1502-1510
Year / Año: 2012
Month / Mes: december

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
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integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston TX 77030, USA, Houston, Texas, United States

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Bibliographic references
Referencias bibliográficas

Gao L, Hammoudi AA, Li F, Thrall MJ, Cagle PT, Chen Y, et al. Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging. J Biomed Opt 17(6):066017, 2012.
Gao L, Li F, Thrall MJ, Yang Y, Xing J, Hammoudi AA, et al. On-the-spot lung cancer differential diagnosis by label-free, molecular vibrational imaging and knowledge-based classification. J Biomed Opt 16:096004, 2011.
Wang ZY, Yang Y, Luo P, Gao L, Wong KK, Wong ST. Delivery of picosecond lasers in multimode fibers for coherent anti-Stokes Raman scattering imaging. Opt Express 18:13017-13028, 2010.
Wang ZY, Gao L, Luo PF, Yang YL, Hammoudi AA, Wong KK, Wong ST. Coherent anti-Stokes Raman scattering microscopy imaging with suppression of four-wave mixing in optical fibers. Optics Express 19:7960-7970, 2011.
Wang ZY, Liu YJ, Gao L, Chen YX, Luo PF, Wong KK, Wong ST. Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging. Optics Letters 36:2967-2969, 2011.

Other articles written by the author Stephen Wong
Otros artículos de Stephen Wong

1. L. Gao, A. A. Hammoudi, F. Li, M. J. Thrall, P. T. Cagle, Y. Chen, J. Yang, X. Xia, Y. Fan, Y. Massoud, Z. Wang, and S. T. Wong, "Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging," J Biomed Opt 17, 066017 (2012).
2. L. Gao, F. Li, M. J. Thrall, Y. Yang, J. Xing, A. A. Hammoudi, H. Zhao, Y. Massoud, P. T. Cagle, Y. Fan, K. K. Wong, Z. Wang, and S. T. Wong, "On-the-spot lung cancer differential diagnosis by label-free, molecular vibrational imaging and knowledge-based classification," J Biomed Opt 16, 096004 (2011).
3. Z. Wang, Y. Yang, P. Luo, L. Gao, K. K. Wong, and S. T. Wong, "Delivery of picosecond lasers in multimode fibers for coherent anti-Stokes Raman scattering imaging," Opt Express 18, 13017-13028 (2010).
4. Z. Y. Wang, L. Gao, P. F. Luo, Y. L. Yang, A. A. Hammoudi, K. K. Wong, and S. T. C. Wong, "Coherent anti-Stokes Raman scattering microscopy imaging with suppression of four-wave mixing in optical fibers," Optics Express 19, 7960-7970 (2011).
5. Z. Y. Wang, Y. J. Liu, L. Gao, Y. X. Chen, P. F. Luo, K. K. Wong, and S. T. C. Wong, "Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging," Optics Letters 36, 2967-2969 (2011).
6. L. Gao, H. Zhou, M. J. Thrall, F. Li, Y. Yang, Z. Wang, P. Luo, K. K. Wong, G. S. Palapattu, and S. T. Wong, "Label-free high-resolution imaging of prostate glands and cavernous nerves using coherent anti-Stokes Raman scattering microscopy," Biomed Opt Express 2, 915-926 (2011).
7. Y. Yang, F. Li, L. Gao, Z. Wang, M. J. Thrall, S. S. Shen, K. K. Wong, and S. T. Wong, "Differential diagnosis of breast cancer using quantitative, label-free and molecular vibrational imaging," Biomed Opt Express 2, 2160-2174 (2011).

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The authors' report was accepted on La crónica del autor fue aprobada el 2021, march 9	Published in siicsalud Publicado en siicsalud 2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

Imaging Diagnosis
/ Diagnóstico por Imágenes

Bioinformatics
/ Informática Biomédica

and secondarily related to the following sections
y secundariamente con las siguientes secciones

Thoracic surgery
Cirugía Mediastinal

Surgery
Cirugía

Neumonology
Neumonología

Clinical Oncology
Oncología Clínica

Oncology
Oncología

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Differential Diagnosis of Lung Carcinoma With Coherent Anti-Stokes Raman Scattering Imaging

Author / Autor
Stephen Wong¹, Liang Gao²

2 Applications Scientist, Chroma Technology Corp, Applications Scientist

Access to the original source
Archives of Pathology & Laboratory Medicine

Article URL: / URL del artículo:
http://arpa.allenpress.com/arpaonline/?request=index-html
URL of Abstract page in Medline: / URL del abstract en Medline:
http://www.ncbi.nlm.nih.gov/pubmed/23194042
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http://www.siicsalud.com/main/distriprinrel.php

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