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Vinay Kumar
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

Role of Gymnema sylvestre on hemodynamic & biochemical parameters

Gymnema sylvestre extract (GSE) treatment significantly reduced myocyte loss by suppressing the levels of cardiac caspase-3, DNA laddering; mean arterial blood pressure and heart rate as well as serum LDH, glucose, apolipoprotein B, and lipids levels. Further, it increased the heart weight and cardiac Na+ K+ ATPase activity in diabetic rats. The present study reports the anti-apoptotic potential of GSE in STZ-induced diabetic cardiomyopathy.

The article was published by
El artículo fue publicado por
International Journal of Green Pharmacy
Volume / Volumen: 7
Number / Número: 1
First and last pages / Páginas inicial-final: 6-11
Year / Año: 2013
Month / Mes: january

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Deptt. of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi, India, New Delhi, Delhi, India

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections. Diabetes Care 21:1414-1431, 1998.
Liu W, Staecker H, Stupak H, Malgrange B, Lefebvre P, Van De Water TR. Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport 9:2609-2614, 1998.
Mahgoub MA, Abd-Elfattah AS. Diabetes mellitus and cardiac function. Mol Cell Biochem 180:59-64, 1998.
Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469-74, 1974.
Murray MT, Pizzorno Jr JE. Diabetes mellitus In: Pizzorno Jr JE, Murray MT, editors. Text Book of Natural Medicine 2nd ed. New York: Churchill Livingstone; 1999. Pp.1193-1218.
World health organization. Quality Control Methods for Medicinal Plant Material. Geneva: WHO; 1998. p. 28.
Wu TG, Li WH, Lin ZQ, Wang LX. Effects of folic acid on cardiac myocyte apoptosis in rats with streptozotocin-induced diabetes mellitus. Cardiovasc Drugs Ther 22:299-304, 2008.

Other articles written by the author Vinay Kumar
Otros artículos de Vinay Kumar

Ahmed Abdullah Khan, Vinay Kumar, Bhulan Kumar Singh, Rahul Singh. Evaluation of wound healing property of Terminalia catappa on Excision wound models in Wistar rats. Drug Research 2013 (accepted for publication). Vinay Kumar, Uma Bhandari, CD Tripathi, Geetika Khanna. Anti-obesity Effect of Gymnema sylvestre Extract on High Fat Diet-induced Obesity in Wistar Rats. Drug Research 2013 (Online published on 10 July, 2013) (DOI: 10.1055/s-00023610) (ISSN 2194-9379) (Impact Factor: 0.775). Vinay Kumar, Ankur Sharma, Lalit Machawal & Ahmed Abdullah Khan. Beneficial Role of Herbal Hepatoprotectants: A Novel Approach to Prevent Hepatotoxicity due to Antituberculosis Treatment. Journal of Biomedical and Pharmaceutical Research 2013; 2 (3): 181-193. (ISSN: 2279 - 0594). Vinay Kumar, Uma Bhandari, C D Tripathi, Geetika Khanna. Ameliorative effect of ethanolic Gymnema sylvestre extract on diabetic cardiomyopathy against streptozotocin-induced diabetes in Wistar rats. International Journal of Green Pharmacy, 2013; 7(1): 6-11 (DOI: 10.4103/0973-8258.111595) (ISSN 0973-8258). Uma Bhandari, Hemantkumar Somabhai Chaudhari, Ajay Narayan Bisnoi, Vinay Kumar, Geetika Khanna, K. Javed. Anti-obesity effect of standardized ethanol extract of Embelia ribes in murine model of high fat diet-induced obesity. Pharma Nutrition 2013; 1: 50-57. ( Vinay Kumar, Uma Bhandari, C D Tripathi, Geetika Khanna. Evaluation of antiobesity and cardioprotective effect of G. sylvestre extract in murine model. Indian Journal of Pharmacology 2012; 44(5): 607-13 (DOI:10.4103/0253-7613.100389) (ISSN 0253-7613) (Impact Factor: 0.727). Uma Bhandari, Vinay Kumar, Naresh Khanna and Bibhu P. Panda. The effect of high fat diet-induced obesity on cardiovascular toxicity in Wistar albino rats. Human and Experimental Toxicology 2011; 30 (9) 1313 – 1321. (doi: 10.1177/0960327110389499) (Impact Factor: 1.772) (ISSN: 0960-3271). Uma Bhandari, Rahila Ahmad, Vinay Kumar & Naresh Khanna. Ameliorative role of atorvastatin on methionine induced hyperhomocysteinmia and hematological changes in albino rats. Indian Journal of Experimental Biology 2011; 49 (2): 132-139 (Impact Factor: 1.295) (ISSN: 0019-5189). Himanshu Sharma, Rahila A. Pathan, Vinay Kumar, Saleem Javed, Uma Bhandari. Anti-apoptotic potential of rosuvastatin pretreatment in murine model of cardiomyopathy. International Journal of Cardiology, 150 (2011) 193–200. (doi:10.1016/j.ijcard.2010.04.008) (ISSN: 0167-5273) (Impact Factor: 4.125). M. Khushtar, V. Kumar, K. Javed, Uma Bhandari. Protective Effect of Ginger oil on Aspirin and Pylorus Ligation-Induced Gastric Ulcer model in Rats. Indian Journal of Pharmaceutical Sciences 2009; 71 (5): 554-558 (Impact Factor: 0.626) (ISSN: 0250-474X) (DOI:10.4103/0250-474X.58195).

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Vinay Kumar was invited by SIIC on
Vinay Kumar fue invitado por SIIC el
2013, july 17
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Diabetología
/ Farmacología

and secondarily related to the following sections

y secundariamente con las siguientes secciones


Information about the full text
Acerca del trabajo completo

Ameliorative Effect of Ethanolic Gymnema Sylvestre Extract on Diabetic Cardiomyopathy Against Streptozotocin-Induced Diabetes in Wistar Rats

Author / Autor
Vinay Kumar1, Uma Bhandari2, Ahmad Abdullah Khan3

3 Mr., Departments Of Pharmacology, Kiet School Of Pharmacy, Ghaziabad (up), India, Research Scholar

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International Journal of Green Pharmacy

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