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Authors' Reports

Gurmit Singh
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo


THE SYSTEM XC- TRANSPORTER AND CANCER-INDUCED BONE PAIN

Cancer cells exist in conditions of elevated oxidative stress. To protect themselves, cancer cells increase the activity of a transport system called system xc- to import necessary cystine in exchange for glutamate. This glutamate is a cell-signalling molecule that has significant implications for bone cell metabolism and pain sensation.

The article was published by
El artículo fue publicado por
Canadian Journal of Physiology and Pharmacology
Volume / Volumen: 91
Number / Número: 1
First and last pages / Páginas inicial-final: 31-37
Year / Año: 2013
Month / Mes: january


This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.
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Principal institution where the research took place
Institución principal de la investigación
McMaster University, Hamilton, Ontario, Canada


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Authors' Report

Crónica del Autor
Print

Bibliographic references
Referencias bibliográficas

IARC. Globocan 2008. 2010; Available from: http://globocan.iarc.fr/factsheets/populations/ factsheet.asp?uno=900.
Cowan RW, Seidlitz EP, Singh G. Glutamate Signaling in Healthy and Diseased Bone. Front Endocrinol (Lausanne) 3:89, 2012.
Doxsee DW, et al. Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy. Prostate 67(2):162-71, 2007.
Gout PW, et al. Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug. Leukemia 15(10):1633-40, 2001.
Guan J, et al. The xc- cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine. Cancer Chemother Pharmacol 64(3):463-72, 2009.
Harrington JF, et al. Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion. Spine (Phila Pa 1976) 25(8):929-36, 2000.
Honore P, et al. Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience 98(3):585-98, 2000.
Huang Y, et al. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res 65(16):7446-54, 2005.
Ishii T, Sugita Y, Bannai S. Regulation of glutathione levels in mouse spleen lymphocytes by transport of cysteine. J Cell Physiol 133(2):330-6, 1987.
Kato S, et al. A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion. Neuroscience 48(4):903-14, 1992.
Kim JY, et al. Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells. Biochim Biophys Acta 1512(2):335-44, 2001.
Lo M, et al. The xc- cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance. Br J Cancer 99(3):464-72, 2008.
McNearney T, et al. Excitatory amino acid profiles of synovial fluid from patients with arthritis. J Rheumatol 27(3):739-45, 2000.
Mercadante S. Malignant bone pain: pathophysiology and treatment. Pain 69(1-2):1-18, 197.
Mercadante S. Pain treatment and outcomes for patients with advanced cancer who receive follow-up care at home. Cancer 85(8):1849-58, 1999.
Murphy TH, et al. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2(6):1547-58, 1989.
Narang VS, et al. Suppression of cystine uptake by sulfasalazine inhibits proliferation of human mammary carcinoma cells. Anticancer Res 23(6C):4571-9, 2003.
Omote K, et al. Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw. Brain Res 787(1):161-4, 1998.
Rosendal L, et al. Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise. Pain 112(3):324-34, 2004.
Sabino MA, Mantyh PW. Pathophysiology of bone cancer pain. J Support Oncol 3(1):15-24, 2005.
Seidlitz EP, et al. Cancer cell lines release glutamate into the extracellular environment. Clin Exp Metastasis 26(7):781-7, 2009.
Seidlitz EP, Sharma MK, Singh G. A by-product of glutathione production in cancer cells may cause disruption in bone metabolic processes. Can J Physiol Pharmacol 88(3):197-203, 2010.
Seidlitz EP, Sharma MK, Singh G. Extracellular glutamate alters mature osteoclast and osteoblast functions. Can J Physiol Pharmacol 88(9):929-36, 2010.
Sevcik MA, et al. Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain 115(1-2):128-41, 2005.
Sharma MK, Seidlitz EP, Singh G. Cancer cells release glutamate via the cystine/glutamate antiporter. Biochem Biophys Res Commun 391(1):91-5, 2010.
Takano T, et al. Glutamate release promotes growth of malignant gliomas. Nat Med 7(9):1010-5, 2001.
Timmerman LA, et al. Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target. Cancer Cell; 2013.
Ungard RG, Seidlitz EP, Singh G. Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. Pain; 2013.
Ungard RG, Seidlitz EP, Singh G. Oxidative stress and cancer pain. Can J Physiol Pharmacol 91(1):31-7, 2013.
von Moos R, et al. Pain and health-related quality of life in patients with advanced solid tumours and bone metastases: integrated results from three randomized, double-blind studies of denosumab and zoledronic acid. Support Care Cancer; 2013.
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WHO, Cancer Pain Relief. 2nd ed, Geneva:World Health Organization; 1996.
Ye ZC, Sontheimer H. Glioma cells release excitotoxic concentrations of glutamate. Cancer Res 59(17):4383-91, 1999.
Zech DF, et al. Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study. Pain 63(1):65-76, 1995.

Other articles written by the author Gurmit Singh
Otros artículos de Gurmit Singh

Ungard, R.G., E.P. Seidlitz, and G. Singh, Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. Pain, 2013.

Cowan, R.W. and G. Singh, Giant cell tumor of bone: a basic science perspective. Bone, 2013. 52(1): p. 238-46.

Sanli, T., et al., Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells. PLoS One, 2012. 7(2): p. e32035.

Cowan, R.W., E.P. Seidlitz, and G. Singh, Glutamate Signaling in Healthy and Diseased Bone. Front Endocrinol (Lausanne), 2012. 3: p. 89.

Sharma, M.K., E.P. Seidlitz, and G. Singh, Cancer cells release glutamate via the cystine/glutamate antiporter. Biochem Biophys Res Commun, 2010. 391(1): p. 91-5.

Seidlitz, E.P., M.K. Sharma, and G. Singh, Extracellular glutamate alters mature osteoclast and osteoblast functions. Can J Physiol Pharmacol, 2010. 88(9): p. 929-36.

Seidlitz, E.P., M.K. Sharma, and G. Singh, A by-product of glutathione production in cancer cells may cause disruption in bone metabolic processes. Can J Physiol Pharmacol, 2010. 88(3): p. 197-203.

Verschoor, M.L., et al., Ets-1 regulates energy metabolism in cancer cells. PLoS One, 2010. 5(10): p. e13565.

Seidlitz, E.P., et al., Cancer cell lines release glutamate into the extracellular environment. Clin Exp Metastasis, 2009. 26(7): p. 781-7.

Duivenvoorden, W.C., et al., Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer. Cancer Res, 2002. 62(6): p. 1588-91.




SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Gurmit Singh was invited by SIIC on
Gurmit Singh fue invitado por SIIC el
2013, august 13
  The authors' report was accepted on
La crónica del autor fue aprobada el
2014, august 1
The authors' report was accepted on
La crónica del autor fue aprobada el
2014, august 1
Published in siicsalud
Publicado en siicsalud
2014, october 30





The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

 
Anatomo-Pathology
/ Anatomía Patológica
 
Biochemistry
/ Bioquímica
 

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Neurology
Neurología

Oncology
Oncología

Osteoporosis and Bone Disorders
Osteoporosis y Osteopatías Médicas

Molecular Biology
Biología Molecular

Biological Chemistry
Química Biológica

Information about the full text
Acerca del trabajo completo


Oxidative Stress and Cancer Pain


Author / Autor
Gurmit Singh1, Robert Ungard2, Eric Seidlitz3

3 Dr, Mcmaster University


Access to the original source
Canadian Journal of Physiology and Pharmacology

Article URL:
/ URL del artículo:
http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp

URL of Abstract:
/ URL del abstract:
http://www.nrcresearchpress.com/doi/abs/10.1139/cjpp-2012-0298?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#.UmbMBCgSqIk

URL of Abstract page in Medline:
/ URL del abstract en Medline:
http://www.ncbi.nlm.nih.gov/pubmed/23368277

URL of Abstract page in Scielo:
/ URL del abstract en Scielo:

URL of Abstract page in Scopus:
/ URL del abstract en Scopus:

URL of Abstract page in Embase:
/ URL del abstract en Embase:

Other data bases:
/ Otras bases de datos:

siic DB:
/ siic DB:
http://www.siicsalud.com/main/distriprinrel.php
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