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Yen-Chung Lin
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

The pleotropic effect of sitagliptin.

The addition of sitagliptin produced a trend of blood pressure lowering effects and decreased the glomerular filtration rate and HbA1c in diabetic patients using an angiotensin II receptor blocker, especially in those with chronic kidney disease.

The article was published by
El artículo fue publicado por
Journal of Experimental and Clinical Medicine
Volume / Volumen: 4
Number / Número: 6
First and last pages / Páginas inicial-final: 334-337
Year / Año: 2012
Month / Mes: december

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Taipei Medical University Hospital, Taipei, Taiwan, Taiwan

Authors' Report

Crónica del Autor

Efectos Pleiotrópicos de la Sitagliptina.
La Sitagliptina y la Presión Arterial en Pacientes con Diabetes Tipo 2

El agregado de sitagliptina tiende a reducir la presión arterial, y disminuye el índice de filtrado glomerular y los niveles de hemoglobina glucosilada en pacientes diabéticos tratados con bloqueantes de los receptores de angiotensina II, especialmente en aquellos con enfermedad renal crónica.
Crónica del Autor

Imprimir nota

Bibliographic references
Referencias bibliográficas

Cervenka L, Wang CT, Mitchell KD, Navar LG. Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats. Hypertension 33:102-107, 1999.
Chan JC, Scott R, Arjona Ferreira JC, Sheng D, Gonzalez E, Davies MJ, et al. Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency. Diabetes Obes Metab 10:545-555, 2008.
Cogan MG. Angiotensin II: a powerful controller of sodium transport in the early proximal tubule. Hypertension 15:451-458, 1990.
Foley RN, Murray AM, Li S, Herzog CA, McBean AM, Eggers PW, et al. Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999. J Am Soc Nephrol 16:489-495, 2005.
Girardi AC, Fukuda LE, Rossoni LV, Malnic G, Reboucas NA. Dipeptidyl peptidase IV inhibition down-regulates Na+-H+ exchanger NHE3 in rat renal proximal tubule. Am J Physiol Renal Physiol 294:F414-F422, 2008.
Hattori S. Sitagliptin reduces albuminuria in patients with type 2 diabetes. Endocr J 58:69-73, 2011.
Jackson EK, Dubinion JH, Mi Z. Effects of dipeptidyl peptidase IV inhibition on arterial blood pressure. Clin Exp Pharmacol Physiol 35:29-34, 2008.
Kwon TH, Nielsen J, Kim YH, Knepper MA, Frøkiaer J, Nielsen S. Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II. Am J Physiol Renal Physiol 285:F152-F165, 2003.
Leong PK, Devillez A, Sandberg MB, Yang LE, Yip DK, Klein JB, et al. Effects of ACE inhibition on proximal tubule sodium transport. Am J Physiol Renal Physiol 290:F854-F863, 2006.
Lestner JM, Baburaj R, Edwards CM. Renal impairment with sitagliptin: is there a need for active monitoring of potential renal toxicity? Br J Hosp Med (Lond) 72:412-413, 2011.
Levin A, Thompson CR, Ethier J, Carlisle EJ, Tobe S, Mendelssohn D, et al. Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin. Am J Kidney Dis 34:125-134, 1999.
Liu FY, Cogan MG. Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule. Modes of action, mechanism, and kinetics. J Clin Invest 82:601-607, 1988.
Marney A, Kunchakarra S, Byrne L, Brown NJ. Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans. Hypertension 56:728-733, 2010.
Mistry GC, Maes AL, Lasseter KC, Davies MJ, Gottesdiener KM, Wagner JA, et al. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension. J Clin Pharmacol 48:592-598, 2008.
Ogawa S, Ishiki M, Nako K, Okamura M, Senda M, Mori T, et al. Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes. Tohoku J Exp Med 223:133-135, 2007.
Pacheco BP, Crajoinas RO, Couto GK, Davel AP, Lessa LM, Rossoni LV, et al. Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats. J Hypertens 29:520-528, 2011.
Tofovic DS, Bilan VP, Jackson EK. Sitagliptin augments angiotensin II-induced renal vasoconstriction in kidneys from rats with metabolic syndrome. Clin Exp Pharmacol Physiol 37:689-691, 2010.
Wang T, Chan YL. Mechanism of angiotensin II action on proximal tubular transport. J Pharmacol Exp Ther 252:689-695, 1990.
Wu MS, Biemesderfer D, Giebisch G, Aronson PS. Role of NHE3 in mediating renal brush border Na+-H+ exchange. Adaptation to metabolic acidosis. J Biol Chem 271:32749-32752, 1996.

Other articles written by the author Yen-Chung Lin
Otros artículos de Yen-Chung Lin

SIIC System of Assisted Editing (SSEA)
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Yen-Chung Lin was invited by SIIC on
Yen-Chung Lin fue invitado por SIIC el
2013, september 2
  The authors' report was accepted on
La crónica del autor fue aprobada el
2023, march 30
The authors' report was accepted on
La crónica del autor fue aprobada el
2023, march 30
Published in siicsalud
Publicado en siicsalud
2023, june 28

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Diabetología
/ Farmacología

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Hipertensión Arterial


Diabetology in Adults
Diabetología en Adultos

Endocrinology and Metabolism
Endocrinología y Metabolismo

Pharmaceutical Medicine
Medicina Farmacéutica

Nefrología y Medio Interno

Information about the full text
Acerca del trabajo completo

Effect of Sitagliptin on Blood Pressure and Estimated Glomerular Filtration Rate in Diabetic Patients Using an Angiotensin II Receptor Blocker

Author / Autor
Yen-Chung Lin1

1 Md, Division Of Nephrology, Department Of Internal Medicine, Taipei Medical University, Taipei, Taiwan, Taipei, Taiwán (Republica Nacionalista China), Attending Physician

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Journal of Experimental and Clinical Medicine

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