Drug reaction with eosinophilia and systemic symptoms: a clinicoepidemiological study

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Olasseri K Reena Mariyath
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Drug reaction with eosinophilia and systemic symptoms
Drug reaction with eosinophilia and systemic symptoms: a clinicoepidemiological study

We observed phenytoin induced DRESS to be relatively mild whereas dapsone drug, female sex and atypical lymphocytes in peripheral smear were associated with severe DRESS. In our study, high eosinophil count was not associated with a bad prognosis.

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Indian Journal of Dermatology, Venereology & Leprology
Volume / Volumen: 80
Number / Número: 3
First and last pages / Páginas inicial-final: 221-228
Year / Año: 2014
Month / Mes: may

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Principal institution where the research took place
Institución principal de la investigación
Department of Dermatology, Government Medical College, Kozhikode, Kozhikode, Kerala, India

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Reacción a drogas con eosinofilia y síntomas sistémicos: un estudio clínico-epidemiológico

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Bibliographic references
Referencias bibliográficas

1. Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 56:609-11, 2007.
2. Chen YC, Chang CY, Cho YT, Chiu HC, Chu CY. Reply to: ''Using a diagnostic score when reporting the long-term sequelae of the drug reaction with eosinophilia and systemic symptoms''. J Am Acad Dermatol 69:1060-2, 2013.
3. Chen YC, Chiu HC, Chu CY. Drug reaction with systemic symptoms. A retrospective study of 60 cases. Arch Dermatol 146:1373-9, 2010.
4. Criado PR, Avancini J, Santi CG, Medrado AT, Rodrigues CE, De Carvalho JF. Drug reaction with eosinophilia and systemic symptoms (DRESS): A complex interaction of drug, viruses and the immune system. Isr Med Assoc J 14:577-82, 2012.
5. Gentile I, Talamo M, Borgia G. Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpes virus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review. BMC Infect Dis 10:49, 2010.
6. Shiohara T, Kano Y, Takahashi R. Current Concepts on the Diagnosis and Pathogenesis of Drug-induced Hypersensitivity Syndrome. JMAJ 52:347-52, 2009.
7. Sasidharanpillai S, Riyaz N, Khader A, Rajan U, Binitha MP, Arunkumar G. Study on reactivation of herpes family of viruses in cutaneous adverse drug reactions. Indian J Dermatol Venereol Leprol 79:725, 2013.
8. Riyaz N, Sarita S, Arunkumar G, Sabeena S, Manikoth N, Sivakumar CP. Drug-induced hypersensitivity syndrome with human herpesvirus-6 reactivation. Indian J Dermatol Venereol Leprol 78:175-7, 2012.

Other articles written by the author Olasseri K Reena Mariyath
Otros artículos de Olasseri K Reena Mariyath

Sarita S, Muhammed K, Najeeba R, Rajan GN, Anza K, Binitha MP, Aparna G. A study on histological features of lepra reactions in patients attending the Dermatology Department of the Government Medical College, Calicut, Kerala, India. Lepr Rev 84:51-64, 2013.
Sasidharanpillai S, Binitha MP, Riyaz N, Ambooken B, Reena mariyath OK, George B, Janardhanan AK, Beegum Sherjeena PV. Childhood leprosy: A retrospective descriptive study from Government Medical College, Kozhikode, Kerala, India. Lepr Rev 85:100-110, 2014.
Riyaz N, Sasidharanpillai S, Rahima S, Bindu V, Shaan M, Raghavan NT, Mohan L, Janardhanan AK. Pyoderma gangrenosum in association with microscopic colitis, idiopathic hypereosinophilic syndrome, selective IgE deficiency and diabetes mellitus. Clin Exp Dermatol 40:629-632, 2015.
Sasidharanpillai S, Riyaz N, Khader A, Rajan U, Binitha MP, Sureshan DN. Severe cutaneous adverse drug reactions: A clinicoepidemiological study. Indian J Dermatol 60:102, 2015.
Sasidharanpillai S, Bindu V, Riyaz N, Beegum Sherjeena PV, Rahima S, Chandrasekhar N. Syphilis among sexually transmitted infections clinic attendees in a tertiary care institution: A retrospective data analysis. Indian J Dermatol Venereol Leprol 80:161-2, 2014.
Sasidharanpillai S, Bindu V, Riyaz N, Beegum Sherjeena PV, Rahima S, Chandrasekhar N. Author's reply: Significance of seropositivity for syphilis in asymptomatic individuals. Indian J Dermatol Venereol Leprol 81:179-81, 2015.
Riyaz N, Manikath N, Sasidharanpillai S, Govindan A, Davul H, Rini MR. Persistent pruritic rash: A rare manifestation and possible poor prognostic sign in adult onset Still's disease. Indian J Dermatol Venereol Leprol 0:0, 0.
Sasidharanpillai S, Riyaz N, Khader A, Rajan U, Binitha MP, Arunkumar G. Study on reactivation of herpes family of viruses in cutaneous adverse drug reactions. Indian J Dermatol Venereol Leprol 79:725, 2013.

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The authors' report was accepted on La crónica del autor fue aprobada el 2023, november 15	Published in siicsalud Publicado en siicsalud 2024, february 13

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

Allergy
/ Alergia

Dermatology
/ Dermatología

and secondarily related to the following sections
y secundariamente con las siguientes secciones

Epidemiology
Epidemiología

Pharmacology
Farmacología

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Drug Reaction With Eosinophilia and Systemic Symptoms: Observations From a Tertiary Care Institution

Author / Autor
Olasseri K Reena Mariyath¹

1 Dr, Government Medical College, Kozhikode, Kozhikode, India, Assistant Professor

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Indian Journal of Dermatology, Venereology & Leprology

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