Authors' Reports

Hua Yan
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo


In order to determine the roles of IL-1beta and IL-10 in the vitreous of PDR, we measured IL-1beta and IL-10 concentration by ELISA. We found vitreous levels of IL-1beta and IL-10 were upregulated in PDR patients, and these two cytokines play roles in regulating the development and progression of PDR.

The article was published by
El artículo fue publicado por
Indian Journal of Ophthalmology
Volume / Volumen: 62
Number / Número: 6
First and last pages / Páginas inicial-final: 699-701
Year / Año: 2014
Month / Mes: june

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China, Tianjin, Tianjin, China

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

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3. Kern TS. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp Diabetes Res 95103, 2007.
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5. Kim SJ, Kim S, Park J, Lee HK, Park KS, Yu HG, et al. Differential expression of vitreous proteins in proliferative diabetic retinopathy. Curr Eye Res 31:231-40, 2006.
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7. Koleva-Georgieva DN, Sivkova NP, Terzieva D. Serum inflammatory cytokines IL-1beta, IL-6, TNF-alpha and VEGF have influence on the development of diabetic retinopathy. Folia Med (Plovdiv) 53:44-50, 2011.
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9. El-Ghrably IA, Dua HS, Orr GM, Fisher D, Tighe PJ. Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy. Br J Ophthalmol 85:461-70, 2001.
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13. Zhou J, Wang S, Xia X. Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathy. Curr Eye Res 37:416-20, 2012.
14. Paine SK, Sen A, Choudhuri S, Mondal LK, Chowdhury IH, Basu A, et al. Association of tumor necrosis factor alpha, interleukin 6, and interleukin 10 promoter polymorphism with proliferative diabetic retinopathy in type 2 diabetic subjects. Retina 32:1197-203, 2012.
15. Hernández C, Segura RM, Fonollosa A, Carrasco E, Francisco G, Simó R. Interleukin-8, monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy. Diabet Med 22:719-22, 2005.
16. Mycliwiec M, Zorena K, Balcerska A, Mycliwska J, Lipowski P, Raczyflka K. The activity of N-acetyl-beta-D-glucosaminidase and tumor necrosis factor-alpha at early stage of diabetic retinopathy development in type 1 diabetes mellitus children. Clin Biochem 39:851-6, 2006.
17. Canataroglu H, Varinli I, Ozcan AA, Canataroglu A, Doran F, Varinli S. Interleukin (IL)-6, interleukin (IL)-8 levels and cellular composition of the vitreous humor in proliferative diabetic retinopathy, proliferative vitreoretinopathy, and traumatic proliferative vitreoretinopathy. Ocul Immunol Inflamm 13:375-81, 2005.

Other articles written by the author Hua Yan
Otros artículos de Hua Yan

Chen S, Zhou S, Zang K, Kong F, Liang D, Yan H. CD73 expression in RPE cells is associated with the suppression of conventional CD4 cell proliferation. Exp Eye Res 127:26-36, 2014.
2. Cui J, Liu Y, Zhang J, Yan H. An experimental study on choroidal neovascularization induced by Krypton laser in rat model. Photomed Laser Surg 32(1):30-6, 2014.
3. Wang J, Chen S, Jiang F, You C, Mao C, Yu J, Han J, Zhang Z, Yan H. Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomy. PLoS One 16;9(10):e110531, 2014.
4. Zheng H, Zhang Z, Luo N, Liu Y, Chen Q, Yan H. Increased Th17 cells and IL 17 in rats with traumatic optic neuropathy. Mol Med Rep 10(4):1954-8, 2014.
5. Yao B, Zhao Q, Yan H, Chen F, Liu L. Correlation between the reduced circulating endothelial progenitor cell counts and elevated intraocular pressure-induced retinal ganglion cell apoptosis. Curr Eye Res 15:1-10, 2014.
6. Ying W, Zhigang Y, Caiyun Y, Jindong H, Haiyan L, Zhuhong Z, Hua Y. Overexpression p21WAF1/CIP1 in suppressing retinal pigment epithelial cells and progression of proliferative vitreoretinopathy via inhibition CDK2 and cyclin E. BMC Ophthalmology 25;14:144, 2014.
7. Zhang W, Yan H. Dysfunction of circulating endothelial progenitor cells in type 1 diabetic rats with diabetic retinopathy, Graefes Arch Clin Exp Ophthalmol 251(4):1123-31, 2013.
8. Han J, Yuan Z, Yan H. Inhibitory effect of adenoviral vector-mediated delivery of p21(WAF1/CIP1) on retinal vascular endothelial cell proliferation and tube formation in cultured rhesus monkey cells (RF/6A). Curr Eye Res 38(6):670-3, 2013.
Yan H, Cui J, Wang Y, Yu Y. Comparison of the effects between Intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor on suppressing choroidal neovascularization in rats. Ophthalmic Res 49(2):81-9, 2013.

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Hua Yan was invited by SIIC on
Hua Yan fue invitado por SIIC el
2014, september 16
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Cirugía
/ Oftalmología

and secondarily related to the following sections

y secundariamente con las siguientes secciones



Workers Health
Medicina del Trabajo

Information about the full text
Acerca del trabajo completo

Roles of Elevated Intravitreal IL-1Beta and IL-10 Levels in Proliferative Diabetic Retinopathy

Author / Autor
Hua Yan1, Mao Chunjie2

2 Doctor, Department Of Ophthalmology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Tianjin-300052, Ch

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Indian Journal of Ophthalmology

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