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AR Khalighi
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The effects of probiotics in prevention or better toleration of SIBO.

For evaluating the efficacy of probiotics on treatment in patients with small intestinal bacterial overgrowth (SIBO) based on preliminary data, it seems that adding probiotic lactol to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome.

The article was published by
El artículo fue publicado por
Indian Journal of Medical Research (IJMR)
Volume / Volumen: 140
Number / Número: 5
First and last pages / Páginas inicial-final: 604-608
Year / Año: 2015
Month / Mes: november

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Quaem hospital of Mashhad University of Medical Sciences (MUMS), Mashhad, Khorasan Razavi, Iran

Authors' Report

Crónica del Autor

La Eficacia de los Probióticos en el Tratamiento de los Pacientes con Sobrecrecimiento Bacteriano en el Intestino Delgado

En la evaluación de la eficacia de los probióticos en el tratamiento de los pacientes con sobrecrecimiento bacteriano en el intestino delgado (SIBO), sobre la base de datos preliminares, parece que el agregado del probiótico Lactol® para la terapia de mantenimiento del SIBO en los casos bajo terapia antibiótica de rutina sería beneficioso en la prevención de las complicaciones de este síndrome.
Crónica del Autor

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Bibliographic references
Referencias bibliográficas

1. Binder HJ. Disorders of Absorption. In: Fauci AS, Kasper DL, Longo DL, Braunwald E, Hauser SL, Jameson JL, editors. Harrison's principles of internal medicine. 18 th ed; New York: McGraw Hill; pp. 2460-76, 2012.
2. Kleigman RM, Behrman RE, Jenson HB, Stanton BF. Nelson textbook of pediatrics. 19 th ed. Philadelphia: PA: Saunders; 2011.
3. Quigley EM. Bacteria: a new player in gastrointestinal motility disorders - infections, bacterial overgrowth, and probiotics. Gastroenterol Clin North Am 36:735-48, 2007.
4. O'Mahony S, Shanhan F. Enteric microbiota and small intestinal bacterial overgrowth. In: Feldman M, Friedman LS, Brandt LJ, editors. Sleisenger & Fordtran's gastrointestinal & liver disease: pathophysiology, diagnosis, management. 9 th ed. Philadelphia: Saunders Elsevier; pp. 1772-7, 2010.
5. Scherezenmeir J, De Verse M. Probiotics, and synbiotics-approaching a definition. Am J Clin Nutr 73:361S-64S, 2001.
6. De Simone C, Ciardi A, Grassi A. Effect of Bifidobacterium bifidum and Lactobacillus on gut mucosa peripheral blood B lymphocytes. Immunopharmacol Immunotoxicol 14:331-40, 1992.
7. Fuller R. Probiotics in human medicine. Gut 32:439-42, 1991.
8. Freter R. Factors affecting the microecology of the gut. In: Fuller R, editor. Probiotics, the scientific basis. London: Champan & Hall; pp. 111-44, 1992.
9. Reid G. Probiotics for urogenital health. Nutri Clin Care 5:3-8, 2002. Back to cited text no. 9
10. Rowland IR, Grasso P. Degradation of N-nitrosamines by intestinal bacteria. Appl Microbiol 29:7-12, 1975.
11. Semard CA, Powell DW. Approach to the patient with diarrhea and malabsorption. In: Goldman L, Ausiello DA, editors. Cecil medicine, 23 th ed. Philadelphia: PA: Saunders Elsevier; pp. 1029, 2008.
12. Soifer LO, Peralta D, Dima G, Besasso H. Comparative clinical efficacy of a probiotic vs. an antibiotic in the treatment of patients with intestinal bacterial overgrowth and chronic abdominal functional distension: a pilot study. Acta Gastroenterol Latinoam 40:323-7, 2010.
13. Barrett JS, Canale KE, Gearry RB, Irving PM, Gibson PR. Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome. World J Gstroenterol 14:5020-4, 2008.
14. Jonkers D, Penders J, Masclee A, Pierik M. Probiotics in the management of inflammatory bowel disease: a systematic review of intervention studies in adult patients. Drugs 72:803-23, 2012.
15. Rohde CL, Bartolini V, Jones N. The use of probiotics in the prevention and treatment of antibiotic-associated diarrhea with special interest in Clostridium difficile-associated diarrhea. Nutr Clin Pract 24:33-40, 2009.
16. Bixquert Jimenez M. Treatment of irritable bowel syndrome with probiotics. An etiopathogenic approach at last? Revista Espanola de Enfermedades Digestivas. Rev Esp Enferm Dig 101:553-64, 2009.

Other articles written by the author AR Khalighi
Otros artículos de AR Khalighi

Differences in availability of diagnostics and treatment modalities for chronic hepatitis b across europe. Accepted at 1-Jul-2015, CLM-15-8578.R2.
Evaluating the efficacy of probiotic on treatment in patients with small-intestinal bacterial overgrowth (sibo). A pilot study. Indian J Med Res 140:579-700, 2014.
Effect of human T-cell lymphotrophic virus type 1 (HTLV-1) in seropositive infertile women on intracytoplasmic sperm injection (ICSI) outcome. Iran J Reprod Med 12(1):15-8, 2014.
Cutaneous manifestations in HTLV-I positive blood donors. Iran J Basic Med Sci 16(3):273-7, 2013.
Outcome of intravenous immunoglobulin-transmitted HTLV-I, hepatitis B, hepatitis C, and HIV infections. Iran J Basic Med Sci 16(3):221-4, 2013.
Correlation of serum HBV viral load, transaminase levels and histological features of liver in chronic HBeAg-negative hepatitis B patients and evaluation the efficacy of the new suggested cut off levels of ALT and AST enzymes with old one (Manuscript submitted - JVH-00052-2013).
The role of Helicobacter pylori eradication in the treatment of chronic urticaria in comparison with its classic treatments. The XXVth International Workshop of the European Helicobacter Study Group, Ljubljana, Slovenia, September 13-15, 2012.
Role of cytokines in patients with arthritis and low back pain brucellosis (21th ECCMID & 27th ICC, Milan, Italy, May 7-10, 2011 - Abstract publications & Medical Journal of Mashhad University of Medical Sciences 53(3):133-137, 2010.
The comparison of two eradicative regimens (OCA: omeprazole, clarithromycin, amoxicillin & OCM: omeprazole, clarithromycin, metronidazole) for Helicobacter pylori induced peptic ulcer diseases in Mashad, Iran. The XXIIIrd International Workshop of the European Helicobacter Study Group, Rotterdam, The Netherlands, September 16-18, 2010. Med Sci J Islamic Azad University of Mashhad 5(4):245-251, 2010
Prevalence of glucose abnormalities in HTLV1 carriers in Mashhad, North East IRAN. Diabetologia Croatica 39-4, 2010.
A case report of fulminant hepatitis due to hepatitis A in a child with G6PD deficiency. Journal of Medical Faculty Guilan University of Medical Sciences 16(61):107-111, 2007.
The efficacy of antibiotic therapy on recovery of tonsilectomy and adenotonsillectomy. Journal of Birjand University of Medical Sciences 13(4):11-15, 2007.
The comparative evaluation of the effects of new anti-Histaminic drugs (loratadine & claritin) in treatment of allergic rhinitis. The Iranian Journal of Otorhinolaryngology 17(42):196-189, 2006.
The comparative evaluation of 4 antibiotic regimens in febrile neutropenic patients with hematologic malignancies. Medical Journal of Mashhad University of Medical Sciences 48(88):136-131, 2005.
The serum & CSF C-reactive protein reassessment in differentiation of aseptic & pyogenic Meningitis. Med Sci J Islamic Azad University of Mashhad 1(2):61-56, 2005.

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AR Khalighi was invited by SIIC on
AR Khalighi fue invitado por SIIC el
2015, may 4
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Gastroenterología
Infectious Diseases
/ Infectología

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Health Care Management
Administración Hospitalaria

Intensive Care
Cuidados Intensivos



Endocrinology and Metabolism
Endocrinología y Metabolismo




Pharmaceutical Medicine
Medicina Farmacéutica

Sports Medicine
Medicina Deportiva

Family Medicine
Medicina Familiar

Internal Medicine
Medicina Interna

Workers Health
Medicina del Trabajo



Information about the full text
Acerca del trabajo completo

Evaluating the Efficacy of Probiotic on Treatment in Patients With Small Intestinal Bacterial Overgrowth (SIBO) - A Pilot Study

Author / Autor
AR Khalighi1

1, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Irán

Access to the original source
Indian Journal of Medical Research (IJMR)

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