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Jesús Muñoz-Estrada
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DISC1 (disrupted-in-schizophrenia-1) is considered a genetic risk factor for neuropsychiatric disorders. In this study, analysis in human olfactory neuronal precursors of schizophrenia and bipolar disorder patients showed decreased DISC1 levels in the cytoplasm, cAMP accumulation and diminished cell migration. The results suggest that these disorders share common molecular pathways that could hinder the neurodevelopmental process.

The article was published by
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CNS Neuroscience & Therapeutics
Volume / Volumen: 21
Number / Número: 5
First and last pages / Páginas inicial-final: 446-453
Year / Año: 2015
Month / Mes: may

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Distribución Subcelular Anormal de DISC1, Niveles de AMPc y Migración Neuronal en la Esquizofrenia y el Trastorno Bipolar

El gen DISC1 (disrupted-in-schizophrenia-1) se considera un factor de riesgo de los trastornos neuropsiquiátricos. En este estudio, el análisis de los precursores neuronales olfatorios de pacientes con esquizofrenia y trastorno bipolar reveló niveles reducidos de DISC1 en el citoplasma, acumulación de AMPc y reducción de la migración celular. Los hallazgos sugieren que estas enfermedades comparten mecanismos moleculares que podrían comprometer el proceso del neurodesarrollo.
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Bibliographic references
Referencias bibliográficas

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Other articles written by the author Jesús Muñoz-Estrada
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Jesús Muñoz-Estrada was invited by SIIC on
Jesús Muñoz-Estrada fue invitado por SIIC el
2015, august 6
  The authors' report was accepted on
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2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
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2021, june 7

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/ Neurología
Mental Health
/ Salud Mental

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Altered Subcellular Distribution of the 75-kDa DISC1 Isoform, cAMP Accumulation, and Decreased Neuronal Migration in Schizophrenia and Bipolar Disorder: Implications for Neurodevelopment

Author / Autor
Jesus Munoz-Estrada1, Gloria Benitez-King2, Isaura Meza3

3 Phd

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CNS Neuroscience & Therapeutics

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