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A.A van Bodegraven
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Changes in local and systemic inflammation-associated cytokines due to Inflammatory Bowel Disease influence the health of bone.
Inflammatory bowel disease and associated extra-intestinal inflammation of bone

Inflammatory bowel disease (IBD) is associated with nutritional deficiencies, decreased absorption of nutrients, decreased physical activity. (Active) IBD leads to increased generation of a mixture of inflammatory cytokines, potentially detrimental for bone, as is the commonly used corticosteroid treatment of IBD. These factors together induce osteoporosis and increased bone fracture risk. Bone-protecting strategies are being suggested.

The article was published by
El artículo fue publicado por
Osteoporosis International
Volume / Volumen: 31
Number / Número: 4
First and last pages / Páginas inicial-final: 637-646
Year / Año: 2020
Month / Mes: april





Principal institution where the research took place
Institución principal de la investigación
Zuyderland Medisch Centrum, Sittard-Geleen, Limburg, Netherlands


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Los cambios en las citoquinas asociadas a la inflamación local y sistémica debidos a la enfermedad inflamatoria intestinal influyen en la salud ósea.
Enfermedad inflamatoria intestinal e inflamación ósea extraintestinal asociada

La enfermedad inflamatoria intestinal (EII) se asocia con deficiencias nutricionales, disminución de la absorción de nutrientes, disminución de la actividad física. La EII (activa) lleva a un aumento de la generación de una combinación de citoquinas inflamatorias, potencialmente perjudiciales para el hueso, al igual que el tratamiento de la EII con corticosteroides que se utiliza habitualmente. Estos factores combinados provocan la osteoporosis y el aumento del riesgo de fractura ósea. Se recomiendan estrategias de protección ósea.
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Bibliographic references
Referencias bibliográficas

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Other articles written by the author A.A van Bodegraven
Otros artículos de A.A van Bodegraven

vanBodegraven AA, Bravenboer N, Witte BI, Dijkstra G, van der Woude CJ, Stokkers PC, et al., on behalf of the Dutch Initiative on Crohn and Colitis (ICC). Treatment of bone loss in osteopenic patients with Crohn's disease; a double blind, randomized trial of oral risedronate 35 mg once weekly or placebo, concomitant with calcium and vitamin D supplementation (Crohn and Bone Study). Gut 63:1424-1430, 2014.
Oostlander AE, Bravenboer N, van Essen HW, Klein-Nulend J, Lems WF, Schulten BA, et al., Dutch Initiative on Crohn and Colitis (ICC). Bone cells from patients with quiescent Crohn's disease show a reduced growth potential and an impeded maturation. J Cell Biochem113:2424-2431, 2012.
Oostlander AE, Everts V, Schoenmaker T, Bravenboer N, van Vliet SJ, van Bodegraven AA, et al. T cell-mediated increased osteoclast formation from peripheral blood as a mechanism for Crohn's disease-associated bone loss. J Cell Biochem 113:260-268, 2012.
Bakker SF, Dik VK, Witte BI, Lips P, Roos JC, van Bodegraven AA. Increase in bone mineral density in strictly treated Crohn's disease patients with concomitant calcium and vitamin D supplementation. J Crohns Colitis 7:377-384, 2013.
Oostlander AE, Bravenboer N, Sohl E, Holzmann PJ, van der Woude CJ, Dijkstra G, et al., on behalf of the Dutch Initiative on Crohn and Colitis (ICC). Histomorphometric analysis reveals reduced bone mass and bone formating in patients with quiescent Crohn's Disease. Gastroenterology 140:116-123, 2011.
Beekman KM, Veldhuis-Vlug AG, van der Veen A, den Heijer M, Maas M, Kerckhofs G, et al. The effect of PPAR-gamma inhibition on bone marrow adipose tissue and bone in C3H/HeJ mice. Am J PhysiolEndocrinolMetab 316(1):E96-E105, 2019.
Bastidas-Coral AP, Bakker AD, Zandieh-Doulabi B, Kleverlaan CJ, Bravenboer N, Forouzanfar T, Klein-Nulend J. Cytokines TNF-alpha, IL-6, IL-17F, and IL-4 differentially affect osteogenic differentiation of human adipose stem cells. Stem Cells Int 2016:1318256, 2016.




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A.A van Bodegraven was invited by SIIC on
A.A van Bodegraven fue invitado por SIIC el
2020, october 29
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, december 7
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, december 7
Published in siicsalud
Publicado en siicsalud
2022, march 7





The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

 
Gastroenterology
/ Gastroenterología
 
Inmunology
/ Inmunología
 

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Endocrinology and Metabolism
Endocrinología y Metabolismo

Osteoporosis and Bone Disorders
Osteoporosis y Osteopatías Médicas

Information about the full text
Acerca del trabajo completo


Perspective on skeletal health in inflammatory bowel disease


Author / Autor
N Bravenboer1

1, Location Vrije Universiteit, Amsterdam, Países Bajos


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Osteoporosis International

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http://link.springer.com/journal/198

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