Conceptos Categóricos

Crónicas de autores

Rodolfo A. Rey *

Autor invitado por SIIC


DIAGNÓSTICO DIFERENCIAL ENTRE HIPOGONADISMO HIPOGONADOTRÓFICO Y RETRASO PUBERAL SIMPLE EN VARONES CON NIVELES BASALES DE FSH

Niveles basales de FSH < 1.2 UI/l confirman el diagnóstico de hipogonadismo hipogonadotrófico, sin necesidad de otra prueba diagnóstica, en varones con pubertad ausente o incompleta. En casos de niveles de FSH > 1.2 UI/l, el valor pico de FSH y LH luego de una infusión de GnRH tiene alta exactitud diagnóstica.

*Rodolfo A. Rey
describe para SIIC los aspectos relevantes de su trabajo
BASAL FOLLICLE-STIMULATING HORMONE AND PEAK GONADOTROPIN LEVELS AFTER GONADOTROPIN-RELEASING HORMONE INFUSION SHOW HIGH DIAGNOSTIC ACCURACY IN BOYS WITH SUSPICION OF HYPOGONADOTROPIC HYPOGONADISM
Journal of Clinical Endocrinology and Metabolism,
95(6):2811-2818 Jun, 2010

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina
Imprimir nota
Referencias bibliográficas
1. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 45:13-23, 1970.
2. Lee PA. Normal ages of pubertal events among American males and females. J Adolesc Health Care 1:26-29, 1980.
3. Sedlmeyer IL, Palmert MR. Delayed puberty: analysis of a large case series from an academic center. J Clin Endocrinol Metab 87:1613-1620, 2002.
4. Grinspon RP, Rey RA. Anti-Müllerian hormone and Sertoli cell function in paediatric male hypogonadism. Horm Res Paediatr 73:81-92, 2010.
5. Sequera AM, Fideleff HL, Boquete HR, Pujol AB, Suárez MG, Ruibal GF. Basal ultrasensitive LH assay: a useful tool in the early diagnosis of male pubertal delay? J Pediatr Endocrinol Metab 15:589-596, 2002.
6. Odink RJ, Schoemaker J, Schoute E, Herdes E, Delemarre-Van de Waal HA. Predictive value of serum follicle-stimulating hormone levels in the differentiation between hypogonadotropic hypogonadism and constitutional delay of puberty. Horm Res 49:279-287, 1988.
7. Zamboni G, Antoniazzi F, Tato L. Use of the gonadotropin-releasing hormone agonist triptorelin in the diagnosis of delayed puberty in boys. J Pediatr 126:756-758, 1995.
8. Kauschansky A, Dickerman Z, Phillip M, Weintrob N, Strich D. Use of GnRH agonist and human chorionic gonadotrophin tests for differentiating constitutional delayed puberty from gonadotrophin deficiency in boys. Clin Endocrinol (Oxf) 56:603-607, 2002.
9. Street ME, Bandello MA, Terzi C, Ibanez L, Ghizzoni L, Volta C, Tripodi C, Virdis R. Leuteinizing hormone responses to leuprolide acetate discriminate between hypogonadotropic hypogonadism and constitutional delay of puberty. Fertil Steril 77:555-560, 2002.
10. Wilson DA, Hofman PL, Miles HL, Unwin KE, McGrail CE, Cutfield WS. Evaluation of the buserelin stimulation test in diagnosing gonadotropin deficiency in males with delayed puberty. J Pediatr 148:89-94, 2006.
11. Ibáñez L, Potau N, Zampolli M, Virdis R, Gussinye M, Carrascosa A, Saenger P, Vicens-Calvet E. Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders: comparison with the gonadotropin-releasing hormone test. J Clin Endocrinol Metab 78:30-35, 1994.
12. Martin MM, Martin AL. Constitutional delayed puberty in males and hypogonadotropic hypogonadism: a reliable and cost-effective approach to differential diagnosis. J Pediatr Endocrinol Metab 18:909-916, 2005.
13. Degros V, Cortet-Rudelli C, Soudan B, Dewailly D. The human chorionic gonadotropin test is more powerful than the gonadotropin-releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delayed puberty. Eur J Endocrinol 149:23-29, 2003.
14. Zevenhuijzen H, Kelnar CJ, Crofton PM. Diagnostic utility of a low-dose gonadotropin-releasing hormone test in the context of puberty disorders. Horm Res 62:168-176, 2004.
15. Fideleff HL, Boquete H, Saskyn N, Holland M. Evaluation of the gonadotropin and prolactin axis by LH-RH infusion and chlorpromazine test on hypogonadotropic hypogonadism and male delayed puberty. J Pediatr Endocrinol Metab 5:149-153, 1992.
16. Smals AG, Hermus AR, Boers GH, Pieters GF, Benraad TJ, Kloppenborg PW. Predictive value of luteinizing hormone releasing hormone (LHRH) bolus testing before and after 36-hour pulsatile LHRH administration in the differential diagnosis of constitutional delay of puberty and male hypogonadotropic hypogonadism. J Clin Endocrinol Metab 78:602-608, 1994.
17. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Moher D, Rennie D, De Vet HC, Lijmer JG. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clin Chem 49:7-18, 2003.
18. Ropelato MG, Escobar ME, Gottlieb S, Bergadá C. Gonadotropin secretion in prepubertal normal and agonadal children evaluated by ultrasensitive time-resolved immunofluorometric assays. Horm Res 48:164-172, 1997.
19. Lanes R, Gunczler P, Osuna JA, Palacios A, Carrillo E, Ramirez X, Garcia C, Paoli M, Villaroel O. Effectiveness and limitations of the use of the gonadotropin-releasing hormone agonist leuprolide acetate in the diagnosis of delayed puberty in males. Horm Res 48:1-4, 1997.
20. Partsch CJ, Hermanussen M, Sippell WG. Differentiation of male hypogonadotropic hypogonadism and constitutional delay of puberty by pulsatile administration of gonadotropin-releasing hormone. J Clin Endocrinol Metab 60:1196-1203, 1985.
21. Kologlu S, Uysal AR, Kologlu LB. The differentiation between constitutional delayed puberty and hypogonadotropic hypogonadism: experience with three newly devised methods. Endocrinologie 26:3-15, 1988.
22. Segal TY, Mehta A, Anazodo A, Hindmarsh PC, Dattani MT. Role of gonadotropin-releasing hormone and human chorionic gonadotropin stimulation tests in differentiating patients with hypogonadotropic hypogonadism from those with constitutional delay of growth and puberty. J Clin Endocrinol Metab 94:780-785, 2009.
23. Mainieri AS, Viera JG, Elnecave RH. Response of the free alpha-subunit to GnRH distinguishes individuals with functional from those with permanent hypogonadotropic hypogonadism. Horm Res 50:212-216, 1998.
24. Mainieri AS, Elnecave RH. Usefulness of the free alpha-subunit to diagnose hypogonadotropic hypogonadism. Clin Endocrinol (Oxf) 59:307-313, 2003.
25. Haavisto AM, Dunkel L, Pettersson K, Huhtaniemi I. LH measurements by in vitro bioassay and a highly sensitive immunofluorometric assay improve the distinction between boys with constitutional delay of puberty and hypogonadotropic hypogonadism. Pediatr Res 27:211-214, 1990.
26. Raivio T, Falardeau J, Dwyer A, Quinton R, Hayes FJ, Hughes VA, Cole LW, Pearce SH, Lee H, Boepple P, Crowley WF Jr, Pitteloud N. Reversal of idiopathic hypogonadotropic hypogonadism. N Engl J Med 357:863-873, 2007.
Otros artículos de Rodolfo A. Rey

1. Rey R, Campo S, Bedecarrás P, Nagle C, Chemes H. Is infancy a quiescent period of testicular development? Histological, morphometric, and functional study of the seminiferous tubules of the cebus monkey from birth to the end of puberty. J Clin Endocrinol Metab 76:1325-31, 1993.
2. Rey R, Lordereau-Richard I, Carel JC, Barbet P, Cate RL, Roger M, Chaussain JL, Josso N. Anti-Müllerian hormone and testosterone serum levels are inversely related during normal and precocious pubertal development. J Clin Endocrinol Metab 77:1220-6, 1993.
3. Al-Attar L, Noël K, Dutertre M, Belville C, Forest MG, Burgoyne PS, Josso N, Rey R. Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse. J Clin Invest 100:1335-1343, 1997.
4. Young J, Rey R, Couzinet B, Chanson P, Josso N, Schaison G. Antimüllerian hormone in patients with hypogonadotropic hypogonadism. J Clin Endocrinol Metab 84:2696-2699, 1999.
5. Lukas-Croisier C, Lasala C, Nicaud J, Bedecarrás P, Kumar TR, Dutertre M, Matzuk MM, Picard JY, Josso N, Rey R. Follicle stimulating hormone increases testicular anti-Müllerian hormone (AMH) production through Sertoli cell proliferation and a non-classical cyclic AMP-mediated activation of the AMH gene. Mol Endocrinol 17:550-561, 2003.
6. Young J, Chanson P, Salenave S, Noël M, Brailly S, O'Flaherty M, Schaison G, Rey R. Testicular anti-Müllerian hormone (AMH) secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab 90:724-728, 2005.
7. Rey R, Venara M, Coutant R, Trabut JB, Rouleau S, Lahlou N, Sultan C, Limal JM, Picard JY, Lumbroso S. Unexpected mosaicism of R201H-GNAS1 mutant-bearing cells in the testes underlie macro-orchidism without sexual precocity in McCune-Albright syndrome. Hum Molec Genet 15:3538-3543, 2006.
8. Bergadá I, Milani C, Bedecarrás P, Andreone L, Ropelato MG, Gottlieb S, Bergadá C, Campo S, Rey R. Time course of the serum gonadotropin surge, inhibins and anti-müllerian hormone (AMH) in normal newborn males during the first month of life. J Clin Endocrinol Metab 91:4092-4098, 2006.
9. Chemes HE, Rey RA, Nistal M, Regadera J, Musse M, González-Peramato P, Serrano A. Physiologic androgen insensitivity of the fetal, neonatal and early infantile testis is explained by the ontogeny of the androgen receptor expression in Sertoli cells. J Clin Endocrinol Metab 93:4408-4412, 2008.
10. Grinspon R, Rey R. Anti-Müllerian hormone and Sertoli cell function in paediatric male hypogonadism. Hormone Research 73:81-92, 2009.

Para comunicarse con Rodolfo A. Rey mencionar a SIIC como referencia:
rodolforey@cedie.org.ar

Autor invitado
15 de septiembre, 2010
Descripción aprobada
9 de noviembre, 2010
Reedición siicsalud
22 de noviembre, 2011

Acerca del trabajo completo
DIAGNÓSTICO DIFERENCIAL ENTRE HIPOGONADISMO HIPOGONADOTRÓFICO Y RETRASO PUBERAL SIMPLE EN VARONES CON NIVELES BASALES DE FSH

Título original en castellano
ALTA EXACTITUD DIAGNOSTCA DEL NIVEL BASAL DE HORMONA FOLICULO-ESTIMULANTE (FSH) Y DEL PICO DE GONADOTROFINAS LUEGO DE LA INFUSION CON HROMONA LIBERADORA DE GONADOTROFINAS (GNRH) EN VARONES CON SOSPECHA DE HIPOGONADISMO HIPOGONADOTROFICO

Autor


Acceso a la fuente original
Journal of Clinical Endocrinology and Metabolism
http://jcem.endojournals.org
Acceso al texto original completo (full text)
http://jcem.endojournals.org/cgi/content/full/95/6/2811?maxtoshow=&hits=10&RESULTFORMAT=&author1=grinspon&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
Acceso al resumen/abstract original
http://www.ncbi.nlm.nih.gov/pubmed/20371659
El artículo se relaciona estrictamente con las especialidades de siicsalud


ua40317
-->