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Pilar Codoñer-Franch *

Autora invitada por SIIC

Es la primera demostración referida del aumento de las poliaminas en niños afectos de obesidad.

INCREMENTO DE LAS POLIAMINAS EN NIÑOS OBESOS

En los niños obesos se encuentra un aumento de las poliaminas en sangre. La espermina (poliamina que presenta mayor poder discriminativo con respecto a la obesidad) se correlaciona con marcadores de inflamación, estrés oxidativo y nitrosativo y de angiogénesis. Esta relación puede apoyar la aparición de comorbilidades en niños obesos. Su relación con el incremento de riesgo cancerígeno en la obesidad merece investigaciones posteriores.

*Pilar Codoñer-Franch
describe para SIIC los aspectos relevantes de su trabajo
POLYAMINES ARE INCREASED IN OBESE CHILDREN AND ARE RELATED TO MARKERS OF OXIDATIVE/NITROSATIVE STRESS AND ANGIOGENESIS
Journal of Clinical Endocrinology and Metabolism,
96(9):2821-2825 Sep, 2011

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*University Hospital Doctor Peset, Valencia, España
Imprimir nota
Referencias bibliográficas
1. Pegg AE. Mammalian polyamine metabolism and function. IUBMB Life 61:880-894, 2009.
2. Persson L. Polyamine homoeostasis. Essays Biochem 46:11-24, 2009.
3. Durante W, Johnson FK, Johnson RA. Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol 34:906-911, 2007.
4. Codoñer-Franch P, Boix-García L, Simó-Jordá R, Del Castillo-Villaescusa C, Maset-Maldonado J, Valls-Bellés V. Is obesity associated with oxidative stress in children? Int J Pediatr Obes 5:56-63, 2010.
5. Codoñer-Franch P, Tavárez-Alonso S, Murria-Estal R, Megías-Vericat J, Tortajada-Girbés M, Alonso-Iglesias E. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis 215:475-480, 2011.
6. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320:1240-1243, 2000.
7. Carrascosa Lezcano A, Fernández García JM, Fernández Ramos C, Ferrández Longás A, López-Siguero JP, Sánchez González E, Sobradillo Ruiz B, Yeste Fernández D; Grupo Colaborador Español. Spanish cross-sectional growth study 2008. Part II. Height, weight and body mass index values from birth to adulthood. An Pediatr (Barc) 68:552-569, 2008.
8. Teixeira D, Santaolaria ML, Meneu V, Alonso E. Dietary arginine slightly and variably affects tissue polyamine levels in male Swiss albino mice. J Nutr 132:3715-3720, 2002.
9. Tsujinaka S, Soda K, Kano Y, Konishi F. Spermine accelerates hypoxia-initiated cancer cell migration. Int J Oncol 38:305-312, 2011.
10. Dumont J, Zureik M, Bauters C, Grupposo MC, Cottel D, Montaye M, Hamon M, Dicimetière P, Amouyel P, Brosseau T. Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events. Arterioscler Thromb Vasc Biol 27:2120-2126, 2007.
11. Rider JE, Hacker A, Mackintosh CA, Pegg AE, Woster PM, Casero Jr RA. Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide. Amino Acids 33:231-240, 2007.
12. Ischiropoulos H. Protein tyrosine nitration-an update. Arch Biochem Biophys 484:117-121, 2009.
13. Hardy LL, Wick DA, Webb JR. Conversion of tyrosine to the inflammation-associated analog 3-nitrotyrosine at either TCR- or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein 33 by CD8 T cells. J Immunol 180:5956-5962, 2008.
14. Bjelakovic G, Beninati S, Bjelakovic B, Sokolovic D, Jevtovic T, Stojanovic I, Rossi S, Tabolacci C, Kocic G, Pavlovic D, Saranac Lj, Zivic S. Does polyamine oxidase activity influence the oxidative metabolism of children who suffer of diabetes mellitus? Mol Cell Biochem 341:79-85, 2010.
15. Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen AL, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J, Laakso M. Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure and glucose metabolism. Mol Cell Biol 27:4953-4967, 2007.
16. Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari A, Pietilä M, Khomutov AR, Jänne J, Alhonen L. Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. J Cell Mol Med 14:1683-1692, 2010.
17. Ledoux S, Queguiner I, Msika S, Calderari S, Rufat P, Gasc JM, Corvol P, Larger E. Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity. Diabetes 57:3247-3257, 2008.
18. Holm PW, Slart RH, Zeebregts CJ, Hillebrands JL, Tio RA. Atherosclerotic plaque development and instability: a dual role forVEGF. Ann Med 41:257-264, 2009.
19. Schipper RG, Van den Heuvel LP, Verhofstad AA, De Abreu RA. Polyamines and DNA methylation in childhood leukaemia. Biochem Soc Trans 35:331-335, 2007.
Otros artículos de Pilar Codoñer-Franch

Codoñer-Franch P, Boix-García L, Simó-Jordá R, Del Castillo-Villaescusa C, Maset-Maldonado J, Valls-Bellés V. Is obesity associated with oxidative stress in children? International Journal of Pediatric Obesity 5:56-63, 2010.
Codoñer-Franch P, Boix-García L, Pons-Morales S, Valls-Bellés V. Oxidant/antioxidant status in obese children compared to pediatric patients with type 1 diabetes mellitus. Pediatric Diabetes 11:251-257, 2010.
Codoñer-Franch P, López-Jaén AB, De la Mano-Hernández A, Sentandreu E, Simó-Jordá R, Valls-Bellés V. Oxidative markers in children with severe obesity following low-calorie diets supplemented with mandarin juice. Acta Paediatrica 99:1841-1846, 2010.
Codoñer-Franch P, Ballester-Asensio E, Martínez-Pons L, Vallecillo-Hernández J, Navarro-Ruíz A, Del Valle-Pérez R. Cystatin C, cardiometabolic risk, and body composition in severe obese children. Pediatric Nephrology 26:301-307, 2011.
Codoñer-Franch P, Tavárez-Alonso S, Murria-Estal R, Megías-Vericat J, Tortajada-Girbés M, Alonso-Iglesias E. Nitric oxide production is increased in severely obese children and related to markers of oxidative stress and inflammation. Atherosclerosis 215:475-480, 2011.
Codoñer-Franch P, Valls-Bellés V, Arilla-Codoñer A, Alonso-Iglesias E. Oxidant mechanisms in childhood obesity: the link between inflammation and oxidative stress. Translational Research 158:369-384, 2011.
Codoñer-Franch P, Tavárez-Alonso S, Simó-Jordá R, Laporta-Martín P, Carratalá-Calvo A, Alonso-Iglesias E. Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children. The Journal of Pediatrics 161:848-854, 2012.
Codoñer-Franch P, Mora-Herranz A, Simó-Jordá R, Pérez-Rambla C, Boix-García L, Faus-Pérez A. Retinol-binding protein 4 levels are associated with parameters of liver and renal function and oxidant/antioxidant status in obese children. The Journal of Pediatrics 163:593-595, 2013.
Codoñer-Franch P, Tavárez-Alonso S, Porcar-Almela M, Navarro-Solera M, Arilla-Codoñer A, Alonso-Iglesias E. Plasma resitin levels are associated to homocysteine, endothelial acivation and nitrosative stress in obese youths. Clinical Biochemistry 47:44-48, 2014.
Porcar-Almela M, Codoñer-Franch P, Tuzón M, Navarro-Solera M, Carrasco-Luna J, Ferrando J. Left ventricular diastolic function and cardiometabolic factors in obese normotensive children. Nutrition, Metabolism and Cardiovascular Diseases 25:108-115, 2015.

Para comunicarse con Pilar Codoñer-Franch mencionar a SIIC como referencia:
pilar.codoner@uv.es

Autora invitada
19 de abril, 2012
Descripción aprobada
23 de septiembre, 2015
Reedición siicsalud
7 de junio, 2021

Acerca del trabajo completo
INCREMENTO DE LAS POLIAMINAS EN NIÑOS OBESOS

Título original en castellano
LAS POLIAMINAS ESTAN AUMENTADAS EN NIÑOS OBESOS Y SE RELACIONAN CON LOS MARCADORES DE ESTRES OXIDATIVO/NITROSATIVO Y ANGIOGENESIS

Autor


Acceso a la fuente original
Journal of Clinical Endocrinology and Metabolism
http://jcem.endojournals.org

El artículo se relaciona estrictamente con las especialidades de siicsalud


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