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Alexandre De Paula Rogerio *

Autor invitado por SIIC

O trabalho contribui (El trabajo contribuye) para que a quercetina possa ser (pueda ser) utilizada futuramente em ensaios clínicos ou mesmo no (o aun para el) tratamento de pacientes com asma.

TRATAMENTO DE PACIENTES COM ASMA

A quercetina demonstra potencial de reduzir os mais (reducir los más) significativos fenótipos da asma (recrutamento de eosinófilos e neutrófilos, produção de muco e de (de moco y de) hiperatividade das vias aéreas). Estes resultados sugerem que a quercetina, pode ser utilizada medicinalmente ou mesmo como complemento de outros fármacos para o tratamento de asma.

*Alexandre De Paula Rogerio
describe para SIIC los aspectos relevantes de su trabajo
QUERCETIN: A FLAVONOID WITH THE POTENTIAL TO TREAT ASTHMA
Brazilian Journal of Pharmaceutical Sciences,
48(4):589-599 Oct, 2012

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Universidade Federal Do Triângulo Mineiro, Uberaba, Brasil
Imprimir nota
Referencias bibliográficas
Calixto JB, Beirith A, Ferreira J, Santos AR, Filho VC, Yunes RA. Naturally occurring antinociceptive substances from plants. Phytother Res 14(6):401-418, 2000.
Calixto JB, Campos MM, Otuki MF, Santos AR. Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules. Planta Med 69(2):973-983, 2004.
De Boer VC, Dihal AA, Van der Woude H, Arts IC, Wolffram GM, Alink GM, Rietjens IM, Keijer J, Hollman PC. Tissue distribution of quercetin in rats and pigs. J Nutr 135(7):1718-1725, 2005.
Fortunato LR, Alves CF, Teixeira MM, Rogerio AP. Quercetin: a flavonoid with the potential to treat asthma. Braz J Pharm Sci 48(4):589-599, 2012.
Middleton E, Chithan K, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52(4):673-751, 2000.
Mukherjee AB, Zhang Z. Allergic asthma: influence of genetic and environmental factors. J Biol Chem 286(38):32883-32889, 2011.
Papiris SA, Manali ED, Kolilekas L, Triantafillidou C, Tsangaris I. Acute severe asthma: new approaches to assessment and treatment. Drugs 69(17):2363-2391, 2009.
Potterat O, Hamburger M. Drug discovery and development with plant-derived compounds. Prog Drug Res 65(45):47-118, 2008.
Rainsford KD. Anti-inflammatory drugs in the 21st century. Subcell Biochem 42:3-27, 2007.
Rogerio AP, Dora CL, Andrade EL, Chaves JS, Silva LF, Lemos-Senna E, Calixto JB. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol Res 61(4):288-297, 2010. Rogerio, A.P, Fontanari, C, Borducchi, E, Keller, A.C, Russo, M., Soares, E.G, Albuquerque, D.A, Faccioli, L.H. Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma. Eur J Pharmacol, v.580, n.1-2, p.262-70, 2008., L.H. Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid. J Pharm Pharmacol, v.58, n.9, p.1265-1273, 2006.
Rogerio AP, Kanashiro A, Fontanari C, Da Silva EV, Lucisano-Valim YM, Soares EG, Facioli LH. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res 56(10):402-408, 2007.
Rogerio AP, Sa-Nunes A, Albuquerque DA, Anibal FF, Medeiros AI, Machado ER, Souza AO, Prado JC Jr, Faccioli LH. Lafoensia pacari extract inhibits IL-5 production in toxocariasis. Parasite Immunol 25(7):393-400, 2003.
Rogerio AP, Sá-Nunes A, Faccioli LH. The activity of medicinal plants and secondary metabolites on eosinophilic inflammation. Pharmacol Res 62(4):298-307, 2010.
Sircar G, Saha B, Bhattacharya SG, Saha S. Allergic asthma biomarkers using systems approaches. Front Genet 8(4):308, 2014.
Sneader W. Drug discovery: a history by Walter Sneader. John Wiley and Sons, Ltd.: West Sussex, England, p.472, 2005.
Verpoorte R. Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development. Drug Discov Today 3(5):232-238, 1999.
Walle T, Walle UK, Halushka PV. Carbon dioxide is the major metabolite of quercetin in humans. J Nutr 131(10):2648-2652, 2001.
Otros artículos de Alexandre De Paula Rogerio

Rogerio AP, Sa-Nunes A, Albuquerque DA, Anibal FF, Medeiros AI, Machado ER, Souza AO, Prado JC Jr, Faccioli LH. Lafoensia pacari extract inhibits IL-5 production in toxocariasis. Parasite Immunology 25:393-400, 2003.
Rogerio AP, Fontanari C, Melo MC, Ambrosio SR, De Souza GE, Pereira PS, Franca SC, Da Costa FB, Albuquerque DA, Faccioli LH. Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid. Jounal of Pharmacy and Pharmacology 58:1265-1273, 2006.
Rogerio AP, Cardoso CR, Fontanari C, Souza MA, Afonso-Cardoso SR, Silva EV, Koyama NS, Basei FL, Soares EG, Calixto JB, Stowell SR, Dias-Baruffi M, Faccioli LH. Anti-asthmatic potential of a D-galactose-binding lectin from Synadenium carinatum latex. Glycobiology 17:795-804, 2007.
Rogerio AP, Kanashiro A, Fontanari C, Da Silva EVG, Lucisano-Valim YM, Soares EG, Faccioli LH. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflammation Research 56:402-408, 2007.
Rogerio AP, Fontanari C, Borducchi E, Keller AC, Russo M, Soares EG, Albuquerque DA, Faccioli LH. Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma. European Journal of Pharmacology 580:262-270, 2008.
Rogerio AP, Andrade EL, Leite DFP, Figueiredo CP, Calixto JB. Preventive and therapeutic anti-inflammatory properties of the sesquiterpene and alpha-humulene in experimental airways allergic inflammatory model. British Journal of Pharmacology 158:1074-1087, 2009.
Rogerio AP, Dora CL, Andrade EL, Chaves JS, Silva LFC, Lemos-Senna E, Calixto, JB . Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacological Research 61:288-297, 2010.
Rogerio AP, Nunes AS, Faccioli, LH. The activity of medicinal plants and secondary metabolites on eosinophilic inflammation. Pharmacological Research 68:298-307, 2010.
Rogerio AP, Haworth O, Croze R, Oh SF, Uddin M, Carlo T, Pfeffer MA, Priluck R, Serhan CN, Levy BD. Resolvin D1 and aspirin-triggered resolvin d1 promote resolution of allergic airways responses. J Immunol 189:1983-91, 2012.
Cornélio Favarin D, Martins Teixeira M, Lemos de Andrade E, De Freitas Alves C, Lazo Chica JE, Artério Sorgi C, Faccioli LH, Paula Rogerio A. Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice. Mediators Inflamm, 2013.

Para comunicarse con Alexandre De Paula Rogerio mencionar a SIIC como referencia:
alexprogerio@biomedicina.uftm.

Autor invitado
9 de enero, 2014
Descripción aprobada
11 de febrero, 2014
Reedición siicsalud
12 de agosto, 2021

Acerca del trabajo completo
TRATAMENTO DE PACIENTES COM ASMA

Título original en castellano
QUERCETINA: UM FLAVONOIDE COM POTENCIAL PARA TRATAR A ASMA

Autor


Acceso a la fuente original
Brazilian Journal of Pharmaceutical Sciences
http://www.scielo.br/scielo.php?script=sci_serial&pid=1984-8250&nrm=iso&rep=&lng=pt

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