Lívia Silva Lobato *

Autora invitada por SIIC

Nosso artigo demonstra o efeito micobactericida da redução de colesterol do hospedeiro através do uso da atorvastatina.

ESTATINAS COMO NOVA ARMA (NUEVA ARMA PARA EL CONTROL DE LA) NO CONTROLE DA HANSENÍASE E TUBERCULOSE

Demonstramos que a redução dos níveis de colesterol em macrófagos e camundongos através do uso de atorvastatina inativa as micobactérias responsáveis pela hanseníase (M. leprae) e tuberculose (M. tuberculosis), além de potencializar o efeito da rifampicina.

*Lívia Silva Lobato
describe para SIIC los aspectos relevantes de su trabajo
STATINS INCREASE RIFAMPIN MYCOBACTERICIDAL EFFECT
Institución principal de la investigación
*Oswaldo Cruz Foundation, Rio de Janeiro, Brasil
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Referencias bibliográficas
Brzostek A, Pawelczyk J, Rumijowska-Galewicz A, Dziadek B, Dziadek J. Mycobacterium tuberculosis is able to accumulate and utilize cholesterol. Journal of Bacteriology 191:6584-6591, 2009.
Ghittoni R, Napolitani G, Benati D, Ulivieri C, Patrussi L, Laghi Pasini F, Lanzavecchia A, Baldari CT. Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases. European Journal of Immunology 36:2885-2893, 2006.
Mattos KA, Lara FA, Oliveira VG, Rodrigues LS, D'Avila H, Melo RC, Manso PP, Sarno EN, Bozza PT, Pessolani MC. Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes. Cellular microbiology 13:259-273, 2011.
Mattos KA, D'Avila H, Rodrigues LS, Oliveira VG, Sarno EN, Atella GC, Pereira GM, Bozza PT, Pessolani MC. Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. J Leukoc Biol 87(3):371-84, 2010. doi: 10.1189/jlb.0609433. Epub 2009 Dec 1. Erratum in: J Leukoc Biol 88(5):1061, 2010.
Mattos KA, Oliveira VC, Berredo-Pinho M, Amaral JJ, Antunes LC, Melo RC, Acosta CC, Moura DF, Olmo R, Han J, Rosa PS, Almeida PE, Finlay BB, Borchers CH, Sarno EN, Bozza PT, Atella GC, Pessolani MC. Mycobacterium leprae intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment. Cellular Microbiology 16:797-815, 2014.
Organization WH. Weekly epidemiological record. WHO (Geneva), 2012.
Organization WH. Surveillance of drug resistance in leprosy: 2010. Releve epidemiologique hebdomadaire/Section d'hygiene du Secretariat de la Societe des Nations = Weekly epidemiological record/Health Section of the Secretariat of the League of Nations 86:237, 2011.
Sarno EN, Grau GE, Vieira LM, Nery JA. Serum levels of tumour necrosis factor-alpha and interleukin-1 beta during leprosy reactional states. Clinical and Experimental Immunology 84:103-108, 1991.

Otros artículos de Lívia Silva Lobato

Neumann Ada S, Dias F de A, Ferreira J da S, Fontes AN, Rosa PS, Macedo RE, Oliveira JH, Teixeira RL, Pessolani MC, Moraes MO, Suffys PN, Oliveira PL, Sorgine MH, Lara FA. Experimental infection of Rhodnius prolixus (Hemiptera, Triatominae) with Mycobacterium leprae indicates potential for leprosy transmission. PLoS One 11(5):e0156037, 2016. doi: 10.1371/journal.pone.0156037. eCollection 2016.
De Toledo-Pinto TG, Ferreira AB, Ribeiro-Alves M, Rodrigues LS, Batista-Silva LR, Silva BJ, Lemes RM, Martinez AN, Sandoval FG, Alvarado-Arnez LE, Rosa PS, Shannon EJ, Pessolani MC, Pinheiro RO, Antunes SL, Sarno EN, Lara FA, Williams DL, Ozório Moraes M. STING-Dependent 2'-5' oligoadenylate synthetase-like production is required for intracellular mycobacterium leprae survival. J Infect Dis pii: jiw144, 2016. [Epub ahead of print]
Lara FA, Pohl PC, Gandara AC, Ferreira Jda S, Nascimento-Silva MC, Bechara GH, Sorgine MH, Almeida IC, Vaz Ida S Jr, Oliveira PL. ATP binding cassette transporter mediates both heme and pesticide detoxification in tick midgut cells. PLoS One 10(8):e0134779, 2015. doi: 10.1371/journal.pone.0134779. eCollection 2015.
Lobato LS, Rosa PS, Ferreira Jda S, Neumann Ada S, da Silva MG, do Nascimento DC, Soares CT, Pedrini SC, Oliveira DS, Monteiro CP, Pereira GM, Ribeiro-Alves M, Hacker MA, Moraes MO, Pessolani MC, Duarte RS, Lara FA. Statins increase rifampin mycobactericidal effect. Antimicrob Agents Chemother 58(10):5766-74, 2014. doi: 10.1128/AAC.01826-13. Epub 2014 Jul 21.
Michellin LB, Barreto JA, Marciano LH, Lara FA, Nogueira ME, Souza VN, Costa MR. Leprosy patients: neurotrophic factors and axonal markers in skin lesions. Arq Neuropsiquiatr 0(4):281-6, 2012.
De Souza Sales J, Lara FA, Amadeu TP, de Oliveira Fulco T, da Costa Nery JA, Sampaio EP, Pinheiro RO, Sarno EN. The role of indoleamine 2,3-dioxygenase in lepromatous leprosy immunosuppression. Clin Exp Immunol 165(2):251-63, 2011. doi: 10.1111/j.1365-2249.2011.04412.x. Epub 2011 May 18.
Mattos KA, Lara FA, Oliveira VG, Rodrigues LS, D'Avila H, Melo RC, Manso PP, Sarno EN, Bozza PT, Pessolani MC. Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes. Cell Microbiol 13(2):259-73, 2011. doi: 10.1111/j.1462-5822.2010.01533.x. Epub 2010 Nov 2.
Silva SR, Tempone AJ, Silva TP, Costa MR, Pereira GM, Lara FA, Pessolani MC, Esquenazi D. Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts. Mem Inst Oswaldo Cruz 105(5):627-32, 2010.
Ribeiro-Resende VT, Ribeiro-Guimarães ML, Lemes RM, Nascimento IC, Alves L, Mendez-Otero R, Pessolani MC, Lara FA. Involvement of 9-O-acetyl GD3 ganglioside in Mycobacterium leprae infection of Schwann cells. J Biol Chem 285(44):34086-96, 2010. doi: 10.1074/jbc.M110.147272. Epub 2010 Aug 25.
Lara FA, Kahn SA, da Fonseca AC, Bahia CP, Pinho JP, Graca-Souza AV, Houzel JC, de Oliveira PL, Moura-Neto V, Oliveira MF. On the fate of extracellular hemoglobin and heme in brain. J Cereb Blood Flow Metab 29(6):1109-20, 2009. doi: 10.1038/jcbfm.2009.34. Epub 2009 Apr 1.

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Acerca del trabajo completo

ESTATINAS COMO NOVA ARMA (NUEVA ARMA PARA EL CONTROL DE LA) NO CONTROLE DA HANSENÍASE E TUBERCULOSE

Título original en castellano
ESTATINAS AUMENTAM O EFEITO MICOBACTERICIDA DA RIFAMPICINA.

Autor
Lívia Silva Lobato¹
1, Laboratório de Microbiologia Celular, Oswaldo Cruz Foundation, Rio de Janeiro, Brasil

Acceso a la fuente original
Antimicrobial Agents and Chemotherapy
http://aac.asm.org/

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