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Dahir Ramos de Andrade Júnior *

Autor invitado por SIIC

O trabalho procura reunir o conhecimento atual sobre a influência genética na evolução crônica das hepatites virais.

A INFLUÊNCIA DO GENOMA HUMANO NO CURSO DAS HEPATITES VIRAIS CRÔNICAS

Os estudos genéticos realizados em pacientes com hepatite viral crônica têm contribuído para o entendimento da sua patogênese. Vários alelos MHC foram correlacionados com evolução clínica mais favorável em pacientes com hepatite viral crônica B e C. Neste sentido, foram identificados em vários estudos 5 alelos relacionados com melhor evolução da hepatite viral B crônica, e cerca de 23 alelos foram correlacionados com melhor evolução da hepatite viral C crônica. Por outro lado, alguns estudos mostram correlação entre alelos específicos e um curso clínico menos favorável das hepatites virais crônicas B e C. A determinação da correlação entre genes específicos e a evolução das hepatites virais crônicas B e C, constitui o primeiro passo para o entendimento da patogênese dessas doenças. O próximo passo será correlacionar estes genes com respostas imunes específicas. Estes achados serão úteis no futuro para o desenvolvimento de estratégias terapêuticas apropriadas para controlar as hepatites virais, bem como melhorar o nosso conhecimento sobre os fatores determinantes do prognóstico dessas doenças. Um maior número de estudos genéticos, envolvendo diferentes populações, é necessário para que mais genes específicos que influenciam a evolução das hepatites virais crônicas possam ser identificados.

*Dahir Ramos de Andrade Júnior
describe para SIIC los aspectos relevantes de su trabajo
THE INFLUENCE OF THE HUMAN GENOME ON CHRONIC VIRAL HEPATITIS OUTCOME
Revista do Instituto de Medicina Tropical de São Paulo,
46(3):119-126 May, 2004

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Laboratório de Investigação Médica 54, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 470, Prédio IMT, Brasil, São Paulo, Brasil
Imprimir nota
Referencias bibliográficas
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Otros artículos de Dahir Ramos de Andrade Júnior

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Para comunicarse con Dahir Ramos de Andrade Júnior mencionar a SIIC como referencia:
dahira@uol.com.br

Autor invitado
12 de agosto, 2004
Descripción aprobada
27 de septiembre, 2005
Reedición siicsalud
26 de septiembre, 2006

Acerca del trabajo completo
A INFLUÊNCIA DO GENOMA HUMANO NO CURSO DAS HEPATITES VIRAIS CRÔNICAS

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A INFLUÊNCIA DO GENOMA HUMANO NO CURSO DAS HEPATITES VIRAIS CRÔNICAS

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