Crónicas de autores

José Angel Delgado Martín *

Autor invitado por SIIC

El trabajo contribuye a aclarar la actitud en el diagnóstico y tratamiento de la azoospermia en la era de la reproducción asistida

LA ACTITUD ANTE EL PACIENTE AZOOSPERMICO: LA VISION DEL UROLOGO

El diagnóstico y tratamiento de la azoospermia sigue siendo uno de los retos más apasionantes en el conocimiento de la infertilidad; existen líneas de investigación prometedoras, como la espermatogénesis in vitro a partir de células precursoras y el autotrasplante de células criopreservadas en pacientes sometidos a tratamientos de radioterapia y quimioterapia.

*José Angel Delgado Martín
describe para SIIC los aspectos relevantes de su trabajo
LA ACTITUD ANTE EL PACIENTE AZOOSPÉRMICO: LA VISIÓN DEL URÓLOGO
Archivos Españoles de Urología,
57(9):1021-1033 Nov, 2004

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Hospital Clínico San Carlos, Madrid, España, Madrid, España
Imprimir nota
Referencias bibliográficas
1. Palermo G, Joris H, Devroey P, et al.: Pregnancies after injection of single spermatozoa into an oocyte. Lancet 1992; 340:17-18.2. World Health Organization. WHO laboratory manual for the examination of human semen and semen cervical mucus interaction. New York: Cambridge University Prees; 1999.3. Chiang H S, Wei H J, Chen Y T. Genetic screening for patients with azoospermia and severe oligo-asthenospermia. Int J. Androl. 2000; 23 suppl2:20-25.4. Oliva R, Ballescá J L.: Valoración genética de la pareja estéril o infértil. En: Temas de Actualidad en Andrología I. Ed. Asociación Española de Andrología. Jarpyo Editores. Madrid 1999; 61-98.5. Simoni M, Gromoll J, Dworniczak B, Rolf C, Abshagen K.: Screening for deletions of the Y chromosome involving the DAZ (Deleted in Azoospermia) gene in azoospermia and severe oligozoospermias. Fertil Steril. 1997; 3:55-59.6. Schoor R A, Elhanbly S, Niederberger C S, et al.: The role of testicular biopsy in the moderm management of male infertility. J. Urol 2002; 167:197-200.7. Tesarik J, Mendoza C, Testart J.: Viable embryos from inyection of round spermatids into oocytes. New England J med. 1995; 333:. 525-531.8. Gil-Salmon, Romero J, Rubio C, et al.: Testicular sperm extraction and intracytoplasmatic sperm inyection.: A chance of fertility in non-obstructive azoospermia. J Urol. 1998; 160:2063-2067.9. Page D, Silver S, Brown L.: Men with infertility caused by AZFc delection can produce sons by intracytoplasmatic sperm inyection, but are likely to transmit the deletion and infertility. Human Repord, 1999; 14, nº7:1722-1726.10 Pang M, Hoegerman S, Cuticchia A, et al.: Detection of aneuploidy for chromosomes 4, 6, 7, 8, 9, 10, 11, 12, 13, 17, 18, 21, X and Y by fluorescence in-situ hybridization in spermatozoa from nine patients with oligoasthenoteratozoospermia undergoing intracytoplasmatic sperm inyection. Human Reprod, 1999; 14, nº5: 1266-1273.11. Hoffman AR, Crowley Jr W F.: Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin releasing hormone. N Engl J Med 1982; 307(20):1237-1241.12. Van Steirteghem A, Verheyen G, Tournaye H.: Assisted reproductive technology by intracytoplasmatic sperm injection in male-factor infertility. Current Opinion in Urology 1996; 6:333-339.13. Johnson, M.: Genetic risks of intracytoplasmatic sperm injection in the treatment of male infertility: recommendations for genetic counseling and screening. Fertil Steril, 1998; 70:397-411.14. Quinzii C, Castellani C. The cystic fibrosis transmembrane regulator gene and male infertility. J endocrinol Invest 2000; 23:684-689.15. Casals T, Ramos M, Giménez J et al. High heterogeneity for cystitis fibrosis in hispanish familes: 75 mutations account for 90% of chromosomes. Hum Genet, 1997; 101:365-370.16. Kerem E, Rave-Harel N. Augarten A. A cystic fibrosis transmembrane conductante regulator splice variant with partial penetrance associated with variable cystic fibrose presentation. Am J Crit Care Med, 1997; 155:1914-1920.17. Sokol R. Infertility in men with cystic fibrosis. Curr Opin Pulm Med 2001; 7:421-426.18. Blanco J, Egozcue J, Vidal F. Meiotic behaviour of the sex chromosomes in three patients with sex chromosome anomalies (XXY, mosaic XY/XXY and XYY) assessed by fluorescence in-situ hybridization. Hum Reprod. 2001;16(5):887-892.19. Wegner HE, Ferst A, Wegner A. Mixed gonadal dysgenesis: a rare cause of primary infertility. Report of two cases and a review of the literature. Urologe A. 1994;33(4):342-346.20. Brugh V, Maduro M, Lamb D. Genetics disorders and infertility.: Urol Clin North Am. 2003;30(1):143-152.21. Antonelli A, Gandini L, Petrinelli P, et al. Chromosomal alterations and male infertility. J. Endocrinol. Invest. 2000; 23, 677-683.22. Andersson M, Page D, Pettay D, et al.: Y ; autosome translocations and mosaicism in the aetiology of 45 X maleness : assignment of fertility factor to distal Yq 11. Hum Genet 1988; 79:2-7.23. Tiepolo L, Zuffardi O.Localization of factors controling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum. Genet. 1976; 34:119-124.24. Zuffardi O, Tiepolo L. Frequencies and types of chromosome abnormalities associated with human male infertility. En: Genetic Control of Gamete Production and Function. London 1982; Serono Clinical Colloquia on Reproduction III. Academic Press, Crosignani PG, Rubin BL (eds); 261-263.25. Vogt PH, Edelman A, Kirsch S, et al. Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum. Mol. Genet 1996; 5:933-943.26. Foresta C, Moro E Ferlin A. Y cromosoma microdeletions and alterations of espermatogénesis. Endocrinol Rev 2001; 22: 226-239.27. Oliva R, Margarit E, Ballescá J. Prevalence of Y chromosome microdelections in oligospermic and azoospermic candidates for intracytoplasmic sperm inyection. Fertil Steril 1998; 70:506-510.28. Martinez M, Bernabé M, Gómez E: Screening for AZF delection in a large series of severly impaired spermatogenesis patients. J Androl. 2000;21:651-655.29 Kent-Frist m, Kol S, Muallem A. The incidence and possible relevance of Y-linked microdelection in babies borm after intracytoplasmic sperm inyection and their infertile fathers. Mol Human Reprod 1996; 2:943-950.30. Tourmaye H, Merdad T, Silver S. No differences in outcome after intracytosplasmatic sperm inyection with fresh or with frozen-thawed epididimal spermatozoa. Hum Reprod 1999; 14:90-95.31. Silber S. Microsurgical TESE and the distribution of spermatogenesis in non-obstructive azoospermia. Hum Reprod 2000; 15,2278-2284.32. Belker A, Sherins R, Dennison-Lagos L. Percutaneous testicular sperm aspiration: a convenient and effective office procedure to retrieve sperm for in vitro fertilization with intracytoplasmic sperm inyection. J Urol 1998; 160:2058-2062.33. Tournaye H, Clasen L, Aytoz A. Fine needle aspiration versus open biopsy for testicular sperm recovery: a controlled study in azoospermic patients with normal espermatogénesis. Hum Reprod 1998; 13:901-904.34. Fishel S, Green S, Bishop M. Pregnancy after intracytoplasmic inyection of a spermatid. Lancet 1995; 345:1841-1842.35. Ghazzawi I, Alhasani S, Taher M. Reporductive capacity of round spermatids compared with mature spermatozoa in a population of azoospermic men. Human Reprod 1999; 14(3):736-740.36. Tesarik J, Guido M, Mendoza C, Greco E. Human spermatogensis in vitro: Respectived effects of follicle-stimulating hormona and testosterone on meiosis, spermiogenesis, and sertoli cell apoptosis. J Clin Endocrinol Metab 1998; 83:4467-4473.37. Kolettis P, Sabanegii E, D´Amico A.: Outcomes for vasectomy reversal performed after obstructive intervals of at least 10 years. Urology 2002; 60:885-888.38. Jarrow J, Transrectal ultrasonography of infertile men. Fertil Steril 1993; 60:1035-1039.39. Vicente J, Ruiz-Castañé E. Cirugía endoscópica del utriculocele. Arch. Esp Urol 1990; 43, 279-283.40. Goluboff E, Stifelman M, Fisco H.: Ejaculatory duct obstruction in infertile male. Urol Nephrol 1995;29:345-349.41. Jarow J, Diagnosis and management of ejaculatory duct obstruction. Tech Urol 1996;2(2):79-85.42. Howard G.: Who asks for vasectomy reversal and why BMJ, 1982; 285:490-492.43. Ramada F, de la Torre L, Tramoyeres A, Canovas J, Sanchez F, Ordono F, Navalon P, Zaragoza J.: Our experience with simplified vasovasostomy. Review of our results during the last 5 years. Arch Esp Urol. 2004;57(1):59-63.44. Holman C, Wisniewski Z, Semmens J,: Population-based outcomes after 28246 in hospital vasectomies and 1902 vasovasoanastomosis in Western Australia. Br J Urol Int 2000;86:1043-1049.45. Belker A, Thomas A, Fuchs E, Results of 1469 microsurgical vasectomy reversals by the Vasovasostomy Study Group. J Urol Nurs 1992; 11(2):93-111.46. Haas Jr G,: Antibody mediated cause of male infertility. Urol Clin North Am 1987; 14:539.47. Linnet L, Hjort T, Fogh-Andersen P.: Association between failure to impregnate after vasovasostomy and sperm agglutinins in semen Lancet 1981; 17(1):117-119.


ua40317