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Isabel Azevedo *

Autor invitado por SIIC

Uso de conceitos e métodos físico-matemáticos para mostrar que quanto maiores são os adipócitos mais fácil é que morram por rotura

QUANTO MAIOR O TAMANHO DOS ADIPÓCITOS, MAIS PROVÁVEL A SUA MORTE POR ROTURA

O tamanho excessivo dos adipócitos facilita a sua rotura. Esta rotura, previsivelmente mais frequente nos adipócitos intra-abdominais, sujeitos a apreciáveis variações de pressão, está na base da chamada de macrófagos e outras manifestações de inflamação. A prevenção da hipertrofia dos adipócitos deverá acompanhar-se duma redução significativa da morbilidade associada à obesidade.

*Isabel Azevedo
describe para SIIC los aspectos relevantes de su trabajo
ADIPOCYTE SIZE AND LIABILITY TO CELL DEATH
Obesity Surgery,
16(6):804-806 Jun, 2006

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Serviço de Bioquímica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
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Referencias bibliográficas
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Weisberg S, McCann D, Desai M, et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-808.
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Xu H, Barnes G, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112:1821-30.
Cinti S, Mitchell G, Barbatelli G, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lip Res 2005; 46:2347-55.
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Carey V J, Walters EE, Colditz GA, et al. Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses' Health Study. Am J Epidemiol 1997; 145:614-9.
Lean MEJ, Han TS and Seidell JC. Impairment of health and quality of life in people with large waist circumference. Lancet 1998; 351:853-6.
Cobb WS, Burns JM, Kercher KW, et al. Normal intraabdominal pressure in healthy adults. J Surg Res 2005; 129:231-5.
Malbrain MLNG, Chiumello D, Pelosi P, et al. Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study. Intensive Care Med 2004; 30:822-9.
Lambert DM, Marceau S, Forse RA. Intra-abdominal pressure in the morbidly obese. Obes Surg 2005; 15:1225-32.
Murphy KG and Bloom SR. Are all fats created equal? Nat Med 2006; 12:32-3.
Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307:426-30.
Berndt J, Kloting N, Kralisch S, et al. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 2005; 54:2911-6.
Hug C, and Lodish HF. Visfatin: a new adipokine. Science 2005; 307:366-7.
Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114:1752-61.
Lambeth JD. Nox enzymes and the biology of reactive oxygen. Nat Rev Immunol 2004; 4:181-9.
Otros artículos de Isabel Azevedo

Negrão MR, Keating E, Faria A, Azevedo I, Martins MJ. Acute effect of tea, wine, beer, and polyphenols on ecto-alkaline phosphatase activity in human vascular smooth muscle cells. J Agric Food Chem 2006; 54:4982-4988.
Negrão MR, Mota A, Azevedo I, Martins MJ. Statins and tissue mineralization: putative involvement of alkaline phosphatase. Med Hypotheses 2006; 67:524-528.
Ribeiro L, Martel F, Azevedo I. The release of 3H-1-methyl-4-phenylpyridinium from bovine adrenal chromaffin cells is modulated by somatostatin. Reg Peptides 2006, in press.
Monteiro R, Azevedo I, Calhau C. Modulation of aromatase activity by diet polyphenolic compounds. J Agric Food Chem 2006; 54:3535-3540.
Monteiro R, Calhau C, Martel F, Faria A, Mateus N, Azevedo I. Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells. Naunyn-Schmiedeberg's Arch Pharmacol 372:147-152, 2005.
Martel F, Keating E, Calhau C, Grundemann D, Schomig E, Azevedo I. Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracelular second messenger systems. Naunyn-Schmiedeberg's Arch Pharmacol 364:487-95, 2001.
Martel F, Keating E, Azevedo I. Effect of P-glycoproteinamodulators on the human extraneuronal monoamine transporter. Eur J Pharmacol 422:31-37, 2001.
Martel F, Ribeiro L, Calhau C, Azevedo I. Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone. Naunyn-Schmiedeberg's Arch Pharmacol 359:303-309, 1999.
Martel F, Martins MJ, Hipólito-Reis C, Azevedo I. Inward transport of [3H]-1-methyl-4-phenylpyridinium in rat isolated hepatocytes: putative involvement of a P-glycoprotein transporter. Br J Pharmacol 119:1519-1524, 1996.
Martel L, Calhau C, Soares da Silva P, Azevedo I. Transport of [3H]MPP+ in na immortalized rat brain endothelial cell line (RBE4). Naunyn-Schmiedeberg's Arch Pharmacol 363:1-10, 2001.

Para comunicarse con Isabel Azevedo mencionar a SIIC como referencia:
isabelaz@med.up.pt

Autor invitado
24 de julio, 2006
Descripción aprobada
28 de septiembre, 2006
Reedición siicsalud
7 de junio, 2021

Acerca del trabajo completo
QUANTO MAIOR O TAMANHO DOS ADIPÓCITOS, MAIS PROVÁVEL A SUA MORTE POR ROTURA



Autor


Acceso a la fuente original
Obesity Surgery
http://www.obesitysurgery.com/

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