Conceptos Categóricos

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José Luis Sánchez Carazo *

Autor invitado por SIIC


SEGURIDAD DEL ETANERCEPT EN LA PSORIASIS

El etanercept es un fármaco biológico para el tratamiento de la psoriasis moderada a grave que presenta un perfil de seguridad alto, en el que destaca únicamente la existencia de reacciones locales en el punto de inyección como efecto adverso más frecuente, sin que se haya detectado aumento de tumores o infecciones.

*José Luis Sánchez Carazo
describe para SIIC los aspectos relevantes de su trabajo
SAFETY OF ETANERCEPT IN PSORIASIS: A CRITICAL REVIEW
Drug Safety,
29(8):675-685, 2006

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*, Valencia, España, Valencia, España
Imprimir nota
Referencias bibliográficas
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Krueger JG. The immunologic basis for the treatment of psoriasis with new biologic agents J Am Acad Dermatol 46:1-23, 2002.
Mizutani H, Ohmoto Y, Mizutani T, Murata M, Shimizu M. Role of increased production of monocytes TNF-alpha, IL-1beta and IL-6 in psoriasis:relation to focal infection, disease activity and responses to treatments. J Dermatol Sci 14(2):145-153, 1997.
Mease PJ. Tumor necrosis factor (TNF) in psoriatic arthritis: Pathophysiology and treatment with TNF inhibitors. Ann Rheum Dis 61;298-304, 2002.
Chaudhari U, Romano P, Mulcahy D et al. Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial. Lancet 357:1842-7, 2001.
Goffe B, Cather JC. Etanercept: an overview. J Am Acad Dermatol 49:S105-11, 2003.
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Zeltser R, Valle L, Tanck C et al. Clinical, histological, and immunophenotypic characteristics of injection site reactions associated with etanercept: a recombinant tumor necrosis factor alpha areceptor Fc fusion protein. Arch Dermatol 137(7):893-9, 2001.
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Chung ES. Packer M, Lo KH. Randomized, double blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis-a, in patients with moderate-to-severe heart failure: results of theAnti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial. Circulation 107:3133, 2003.
Lowell DJ, Gianini EH, Reiff EH et al. Etanercept in children with polyarticular juvenike rheumatoid artritis. N Engl J Med 342(11):763-9.
Peterson JR, Hsu FC, Simkin PA et al. Effect of tumour necrosis factor a antagonists on serum transaminases and viraemia in patients with rheumatoid artritis and chronic hepatitis C infection. Ann Rheum Dis 62:1078-82, 2003.
Allen EJ, Hurley Y, Leonardi C. Etanercept therapy in psoriasis patients with hepatitis C. In American Academy of Dermatology 18-22, 2005; Schaumburg (IL): American Academy of Dermatology 2004.


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