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PAPEL DE LOS RECEPTORES DE KAINATO EN LA DEPRESION DE LA TRANSMISION SINAPTICA GLUTAMATERGICA EN LA SINAPSIS FIBRA MUSGOSA-CA3 DE HIPOCAMPO

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PAPEL DE LOS RECEPTORES DE KAINATO EN LA DEPRESION DE LA TRANSMISION SINAPTICA GLUTAMATERGICA EN LA SINAPSIS FIBRA MUSGOSA-CA3 DE HIPOCAMPO

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Los receptores de glutamato de tipo kainato participan postsinápticamente en la neurotransmisión y presinápticamente en la modulación de la liberación de neurotransmisor.
rodriguezmoreno9.jpg Autor:
Antonio Rodríguez Moreno
Columnista Experto de SIIC

Institución:
UNIVERSIDAD PABLO DE OLAVIDE

Artículos publicados por Antonio Rodríguez Moreno
Coautor
José Vicente Negrete Díaz* 
DOCTOR EN PSICOLOGÍA, UNIVERSIDAD PABLO DE OLAVIDE, Sevilla, España*
Recepción del artículo
15 de Abril, 2009 		Aprobación
23 de Abril, 2009
Primera edición
26 de Octubre, 2009 		Segunda edición, ampliada y corregida
7 de Junio, 2021

PAPEL DE LOS RECEPTORES DE KAINATO EN LA DEPRESION DE LA TRANSMISION SINAPTICA GLUTAMATERGICA EN LA SINAPSIS FIBRA MUSGOSA-CA3 DE HIPOCAMPO

Resumen
Los receptores de glutamato de tipo kainato (KAR) participan postsinápticamente en la neurotransmisión y presinápticamente en la modulación de la liberación de neurotransmisor. Se ha determinado el papel de los KAR en la modulación de la liberación de neurotransmisor, así como los mecanismos mediante los cuales los KAR inducen una disminución de la liberación de glutamato y si tal efecto tiene un papel en la depresión de larga duración. Para ello se registraron corrientes postsinápticas excitadoras provocadas, empleando la técnica de patch clamp en su configuación de célula completa y potenciales de campo, en rodajas de hipocampo de ratón. La activación de los KAR presinápticos en la sinapsis fibra musgosa-CA3 (MF-CA3) de hipocampo, produce una inhibición de la liberación de glutamato mediada por una proteína Gi/o sensible a la toxina pertúsica e implica la participación de la vía AC/cAMP/PKA; además, esta depresión converge con la mediada por la activación de receptores metabotrópicos de glutamato del Grupo II en la misma sinapsis y con la depresión de larga duración inducida por un protocolo de estimulación de baja frecuencia en la misma sinapsis, lo que sugiere que los receptores de kainato podrían tener algún papel en este tipo de plasticidad.

Palabras clave
kainato, receptores de glutamato, rodajas, hipocampo, modulación, metabotrópico


Artículo completo
(castellano)
Extensión:  +/-7.65 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

ROLE OF KAINATE RECEPTORS IN GLUTAMATERGIC SYNAPTIC TRANSMISSION DEPRESSION AT MOSSY FIBER-CA3 HIPPOCAMPAL SYNAPSE

Abstract
Glutamate receptors of kainate type (KARs) are postsynaptically involved in synaptic transmission and presynaptically they modulate neurotransmitter release at mossy fiber-CA3 synapses. We have determined the role of KARs in the modulation of glutamate release, the mechanisms involved in KARs-mediated depression of glutamate release and the effect of this depression in long-term depression (LTD), a form of presynaptic plasticity at this synapse. We recorded excitaroty postsynaptic currents by using whole-cell configuration of patch clamp technique and additionally we performed some extra cellular recordings in mice slices. The activation of presynaptic KARs produces an inhibition of glutamate release at MF-CA3 synapse that is mediated by a G-protein sensitive to pertussis toxin and involves the AC/cAMP/PKA signalling cascade. The depression mediated by activation of KARs converges with the depression mediated by the activation of group II mGluRs at the same synapse and with induced LTD by using a low frequency stimulation protocol, suggesting that KARs have a role in this type of plasticity.

Key words
kainate, glutamate receptors, slices, hippocampus

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Neurología
Relacionadas: Bioquímica, Diagnóstico por Laboratorio, Salud Mental



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Enviar correspondencia a:
Antonio Rodríguez Moreno, Universidad Pablo de Olavide (Edificio 21), 41013, Ctra. de Utrera km 1, 41013, Sevilla (España), Sevilla, España
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