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ASPECTOS GENETICOS DA SUSCETIBILIDADE DO HOSPEDEIRO A HANSENIASE

ASPECTOS GENETICOS DA SUSCETIBILIDADE DO HOSPEDEIRO A HANSENIASE

(especial para SIIC © Derechos reservados)
Esta revisão oferece uma síntese dos últimos avanços obtidos na área a partir de estudos genéticos epidemiológicos e funcionais.
tavoramira9_91410.jpg Autor:
Marcelo Távora Mira
Columnista Experto de SIIC

Institución:
Pontifïcia Universidade Católica do Paraná


Artículos publicados por Marcelo Távora Mira
Coautores
Angela Schneider Francio* Renata Helena Monteiro Sindeaux** Vinicius Medeiros Fava*** Geovana Brotto Ramos**** Vanessa Santos Sotomaior***** 
Candidata a mestrado, Pontifïcia Universidade Católica do Paraná, Curitiba, Brasil*
Especialista, candidata a doutorado, Pontifïcia Universidade Católica do Paraná, Curitiba, Brasil**
Graduado, candidato a doutorado, Pontifïcia Universidade Católica do Paraná, Curitiba, Brasil***
Graduada, candidata a mestrado, Pontifïcia Universidade Católica do Paraná, Curitiba, Brasil****
Doutora, Pontifïcia Universidade Católica do Paraná, Curitiba, Brasil*****
Recepción del artículo
10 de Agosto, 2010
Aprobación
20 de Octubre, 2010
Primera edición
24 de Noviembre, 2010
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
Hanseníase é uma doença infecciosa crônica que ainda afeta aproximadamente 215 000 pessoas em todo o mundo. Observações clínicas e epidemiológicas sugerem que apenas uma pequena parcela de indivíduos expostos ao Mycobacterium leprae desenvolvem a doença. Hoje, sabe-se que mecanismos de controle da suscetibilidade a fenótipos da doença dependem, em grande parte, das características genéticas do hospedeiro. Esta revisão oferece uma síntese dos últimos avanços obtidos na área a partir de estudos genéticos epidemiológicos e funcionais.

Palabras clave
hanseníase, formas clínicas, estados reacionais, estudos funcionais, genética do hospedeiro, polimorfismos


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Abstract
Leprosy is a chronicle infectious disease that still affects approximately 215 000 individuals worldwide. Clinical and epidemiological observations suggest that only a small proportion of the population exposed to Mycobacterium leprae develop the disease. Today, it is known that mechanisms controlling susceptibility to leprosy phenotypes strongly depend on the genetic background of the host. This review summarizes the latest advances in the field, obtained from genetic epidemiology and functional studies.

Key words
leprosy, leprosy clinical forms, leprosy reactions, functional studies, host genetics, polymorphisms


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Dermatología, Infectología
Relacionadas: Anatomía Patológica, Atención Primaria, Diagnóstico por Laboratorio, Epidemiología, Genética Humana, Medicina Interna, Salud Pública



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Enviar correspondencia a:
Marcelo Távora Mira, Pontifïcia Universidade Católica do Paraná, 80.215-901, Rua Imaculada Conceição, 1155, PPGCS- CCBS, Curitiba, Brasil
Bibliografía del artículo


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