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CONTROVERSIAS ACERCA DE INFECCION POR HELICOBACTER PYLORI Y EPIDEMIOLOGIA DEL CANCER GASTRICO

(especial para SIIC © Derechos reservados)
Se cree que la infección por H. pylori se asocia con la aparición de cáncer gástrico, pero muchos estudios han arrojado resultados contradictorios. En la actualidad, H. pylori no parece tener una asociación de tipo "causa y efecto" con el cáncer gástrico. Se postula que la clasificación de este patógeno dentro del grupo de los carcinógenos humanos del grupo 1 fue prematura.
Autor:
Matthew Tanko
Columnista Experto de SIIC

Institución:
University of Botswana School of Medicine


Artículos publicados por Matthew Tanko
Coautores
Sandro Vento* Francesca Cainelli* 
University of Botswana School of Medicine, Gaborone, Botswana*
Recepción del artículo
20 de Septiembre, 2011
Aprobación
5 de Mayo, 2012
Primera edición
24 de Julio, 2012
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
Se cree que la infección por Helicobacter pylori se asocia con la aparición de cáncer gástrico. De hecho, varios estudios han postulado, probado y supuestamente demostrado esta asociación. Desafortunadamente, muchos de estos estudios han arrojado resultados contradictorios. Al parecer, en algunas ocasiones existe una asociación sólida, pero en otras oportunidades no queda claro si esto es así. Al menos el 50% de todos los estudios destinados a demostrar esta asociación han observado una asociación negativa entre esta bacteria y el cáncer gástrico. Incluso aquellos que han logrado resultados con asociación positiva no son reproducibles, lo que sugiere una falta de consistencia. Por otra parte, los datos epidemiológicos son insuficientes para demostrar la causalidad por sí mismos. Tan es así que los experimentos que se han realizado en animales para establecer un vínculo claro entre la infección y el cáncer gástrico no han sido muy exitosos. Por ende, en la actualidad, Helicobacter pylori no parece tener una asociación de tipo "causa y efecto" con el cáncer gástrico. Creemos que la clasificación de este patógeno por la AIIC en 1994 dentro del grupo de los carcinógenos humanos del grupo 1 fue prematura, y que se justifica realizar una reclasificación de esta bacteria en una categoría más apropiada, debido a la falta de pruebas consistentes.

Palabras clave
Helicobacter pylori, cáncer gástrico, epidemiología


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Abstract
Helicobacter pylori infection is thought to be associated with the development of gastric cancer. Indeed several studies have postulated, tested and supposedly proven this association. Unfortunately many of these studies have actually produced conflicting results. It sometimes seems that the association exists and is strong, but at other times there is uncertainty as to whether any material association between this pathogen and gastric cancer can be proven. At least 50% of all studies designed to prove this association have generated results with a negative association between Helicobacter pylori and gastric cancer. Even those that have had positive association results are not reproducible, suggesting a lack of consistency. Moreover, epidemiological evidence alone is inadequate to prove causality. In fact, the few animal experiments that have been conducted to establish a definite link with gastric cancer have not been so successful in doing so. At present therefore, Helicobacter pylori does not seem to have a “cause and effect” association with gastric cancer. We think that the classification of this pathogen by IARC in 1994 as a Group 1 human carcinogen was premature and a re-classification of Helicobacter pylori into a more appropriate category may be warranted due to lack of consistent evidence.

Key words
Helicobacter pylori, gastric cancer, epidemiology


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página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Gastroenterología, Oncología
Relacionadas: Anatomía Patológica, Epidemiología, Infectología, Salud Pública



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Bibliografía del artículo

1. Axon A. T. R. Relationship between Helicobacter pylori gastritis, gastric cancer and gastric acid secretion. Advances in Medical Sciences (2007); 52: 55-60.
2. Tanko M. N, Manasseh A.N, Echejoh G.O et al. Relation between Helicobacter Pylori, inflammatory (neurtophil) activity, chronic gastritis, gastric atrophy and intestinal metaplasia. Nig J Clin Pract (2008); 11(3): 210 – 214.
3. Takafumi A, Yasukuyi G, Osamu m et al. Causal role of H. pylori infection in gastric cancer. World J Gastroenterol (2006); 12(2): 181-186.
4. Brown L. M. Helicobacter pylori epidemiology and routes of transmission. Epidemiol Rev (2000); 22: 283-297.
5. Vahid M, Masha M, Hamid M. S, Mohamme R. Z. Helicobacter pylori infection and expression of DNA mismatch repair proteins. World J Gastroenterol (2008); 14(43): 6717 – 6721.
6. Ihsan A, Maysloon A, Abdulmohsin J, Saad H. Clinical findings and prevalence of Helicobacter pylori in patients with gastritis B in Al-Basrah Governorate. OMJ (2009); 24(3): 208-211.
7. Cansel T, Mustafa E, Nukhet B, Sibel Y, Elife E, Benan K. Helicobacter pylori and histopathological findings in patients with dyspepsia. Turk J Gastroenterol (2011); 22(2): 122-127.
8. Tanko M .N, Echejoh G.O, Mandong B.M, Manasseh A.N, Malu O.A. Gastric histopathological findings in mucosal biopsies of symptomatic patients in Jos, Central Nigeria. Nig J Med (2007); 16(2): 113-118.
9. Bruce E.D, Hartley C, Martin J.B. Helicobacter pylori. Clin Microbiol Rev (1997); 10(4): 720-741.
10. Jones D.M, Lessells A.M, Eldridge J. Campylobacter-like organisms on the gastric mucosa: culture, histological and serological studies. J Clin Path (1984); 37: 1002-1006.
11. Langerberg M.L, Tybyat G.N.J, Schipper M.E.I, Rietra P.G.M, Zanen H.G. Campylobacter-like organisms in the stomach of patients and healthy individuals. Lancet Inf Dis (1984); 1348.
12. McNulty C.M.A, Watson D.M. Spiral bacteria of the gastric antrum. Lancet Inf Dis (1984); 1068-1069.
13. Segal I, Ally R, Mitchell H. Helicobacter pylori-an African persepective. Q J Med (2001);94: 561-565.
14. Personnet J. Helicobacter pylori: The size of the problem. Gut (1998); 43(1): 6-9.
15. Personnet J. The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther (1995); 9: 45-51.
16. Personnet J, Blaser M.J, Perez-Perez G.I, Hargrett-Bean N, Tauxe R.V. Symptoms and risk factors of Helicobacter pylori infection in a cohort of epidemiologists. Gastroenterol (1998); 102: 4-46.
17. Banatvala N, Mayo K, Megradd F, Jenings R, Deeks J.J, Feldman R. The cohort effect and Helicobacter pylori. J Inf Dis (1993); 219-221.
18. German R.A, Guadalupe A, Geny F.Z. Helicobacter pylori. Recent Advances in the study of its pathogenecity and prevention. Salud Publica Mex (2001); 43: 237 – 247. English version available at http://www.insp.mx/salud/index.html.
19. Eslick G.D. Helicobacter pylori infection causes gastric cancer? A review of the epidemiological, meta-analytic and experimental evidence. World J Gastroenterol (2006);12(19): 2991-2999.
20. Dominci P, Bellentani S, Di Biase A.R et al. Familial clustering of Helicobacter pylori infection: Population-based study. Br Med J (1999); 319 (7209):537 – 540.
21. Aba R, Gerardo N. Diet, Helicobacter pylori infection and gastric cancer: Evidence and controversies. World J Gastroenterol (2007); 13(21): 2901 – 2912.
22. Annie O.O.C, Benjamin C.Y.W, Shui-K.L. Gastric cancer: past, present and future. Can J Gatsreoenterol (2001); 15(7): 469-474.
23. Brown L.M, Devesa S.S. Epidemiologic trends in oesophageal and gastric cancer in the United States. Surg Oncol Clin N Am (2002); 11: 235-256.
24. Parkin D.M, Whelan S.L, Ferlay J. Cancer incidence in five continents,Vol. VII. Lyon France: IARC (1997): 822 -823
25. Stewart B.W, Kleihues P. World Cancer Report Lyon: IARC Press 2003.
26. Yamamoto S. Stomach cancer incidence in the world. Jpn J Clin Oncol (2001); 31: 471.
27. Nomura A. Stomach cancer. In: Schottenfeld D, Fraumeni J.F, eds. Cancer Epidemiology and prevention 2nd edn. New York, NY, Oxford University Press (1996): 707-724.
28. Liu Y, Kaneko S, Sobue T. Trends in reported incidences of gastric cancer by tumour location from 1975 to 1989 in Japan. Int J Epidemiol(2004) ;33(4):808-15.
29. Michael A.J, McCall M.G, Hartshorne J.M, Woodings T.L. Patterns of gastrointestinal cancer in European migrants to Australia: The role of dietary change. Int J Cancer (1980); 25: 431-437.
30. El-Serag H.B, Mason A.C, Petersen N, Key C.R. Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USA. Gut (2002); 50: 368-372.
31. Shen H, Xu Y, Qian Y et al. Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. Int J Cancer (2000); 88: 601 – 606.
32. Munoz N, Correa P, Cuello C, Duque E. Histologic types of gastric adenocarcinoma in high – and low-risk areas. Int J Cancer (1968); 3: 809 – 818.
33. Fielding J.W.L, Powell J, Allum W.H. Cancer of the stomach. London: The MacMillan Press 1989.
34. IARC Unit of Descriptive Epidemiology: WHO Cancer Mortality databank. Cancer Mondial (2001), available from URL: www-dep.iarc.fr/ataava/globocan/who/htm
35. McNulty C.A. The discovery of Campylobacter-like organisms. Curr Top Microbil Immunol (1999); 241: 1-9.
36. Allen P. What is the story of Helicabacter pylori? Lancet (2001); 357 – 694.
37. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of carcinogenic risks to humans. Lyon 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum (1994); 61:1-241
38. Huang J.Q, Sridhar S, Chen Y, Hunt R.H. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterol (1998); 114: 1169-1174.
39. Eslick G.D, Lim L.L, Byles J.E, Xia H.H, Talley N.J. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am J Gastroenterol (1999); 94: 2373 – 23 79.
40. Danesh J. Helicobacter pylori and gastric cancer: a systematic review of epidemiological studies. Aliment Pharmacol Ther (1999); 13: 851- 856.
41. Estevens J, Fidalgo P, Tendeiro T et al. Anti-Helicobacter pylori antibodies prevalence and gastric adenocarcinoma on Portugal: a report of a case control study. Eur J Cancer Rev (1993); 2: 377 – 380.
42. Kikuchi S, Wado O, Nakajira T et al. Serum anti-Helicobacter pylori antibody and carcinoma among adults: Research Group on Prevention of gastric cancer among young Adults. Cancer (1995); 75: 2759 -2793.
43. Eslick G.D, Yan P, Xia H.H, Murray H, Spurrett B, Talley N.J. Foetal intrauterine growth restriction with Helicobacter pylori infection. Aliment Pharmacol Ther (2002); 16: 1677-1682.
44. Aceti A, Are R, Sabino G et al. Helicobacter pylori active infection in patients with acute coronary heart disease. J Infect (2004); 49: 8-12.
45. Zullo A, Hassan C, Morimi S. Hepatic encephalopathy and Helicobacter pylori: a critical appraisal. J Clin Gastroenterol (2003); 37: 164-168.
46. Tomasi P.A, Dore M.P, Fanciulli G, Sancin F, Realdi G, Delitala G. Is there anything to the reported association between Helicobacter pylori infection and autoimmume thyroiditis? Dig Dis Sci (2005); 50: 385 – 388.
47. Pierantozzi M, Pietroiusti A, Galante A et al. Helicobacter pylori-induced reduction of acute levodopa absorption in Parkinson’s disease patients. Ann Neurol 50: 686-687.
48. Israel D.A, Peek R.M. Pathogenesis of Helicobacter pylori-induced gastric inflammation. Aliment Pharmacol Ther (2001); 15: 1271-1290.
49. Yamaguchi N, Kakizoe T. Synergistic interaction between Helicobacter pylori gastritis and gastric cancer. Lancet Oncol (2001); 2: 88 – 94.
50. Peek R.M, Blaser M.J. Helicobacter pylori and gastrointestinal adenocarcinomas. Nat Rev Cancer (2002); 2: 28-37.
51. Xia H.H, Talley N.J. Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis. Am J Gastroenterol (2001); 96: 16-26.
52. Crespi M, Citarda F. Helicobacter pylori and gastric cancer: an overrated risk? Scand J Gastroenterol (1996); 31: 1041 -1046.
53. Tajima K. Challenging epidemiological strategy for paradoxical evidence on the risk of gastric cancer from Helicobacter pylori infection. Jpn J Clin Oncol (2002); 32: 275-276.
54. Lunet N, Barros H. Helicobacter pylori and gastric; facing the enigmas. Int J Cancer (2003); 106: 953-960.
55. GLOBOCAN (2002): IARC, Lyon France (http://www.dep.iarc.fr/).
56. Wong B.C, Lam S.K, Wong W.B et al. Helicobacter pylori eradication to prevent gastric cancer in a high risk region of China: a randomized controlled trial. JAMA (2004); 291: 187-194.
57. Kamada T, Hata J, Sugiu K et al. Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9-year prospective follow-up study in Japan. Alimen Pharmacol Ther (2005); 21: 1121-1126.
58. Xue F.B, XU Y.Y, Wan Y, Pan B.R, Ren J, Fan D.M. Association of Helicobacter pylori with gastric cancer : a meta-analysis. World J Gastroenterol (2001); 7: 801-804.
59. Axon A. Review article: Gastric cancer and Helicobacter pylori. Aliment Pharmacol Ther (2002); 16(4): 83-88
60. Evans A.s. Causation and disease: a chronological journey. The Thomas Parran Lecture. Am J Epidemiol (1978); 108: 249 – 258.
61. Dixon M.F, Ganta R.M, Yardley J.H, Correa P. Classification and grading of gastritis: The Updated Sydney System. Am J Surg Pathol (1996); 20: 1168 – 1181.
62. Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M. Helicobacter pylori infection induces gastric cnacer in Mongolian gerbils. Gastroenterology (1998); 115: 642-648.
63. Marshall B.J, Armstrong J.A, McGechie D.B, Glancy R.J. Attempt to fulfill Koch’s postulates for pyloric campylobacter. Med J Aust (1985); 142 : 436-439.
64. Marshall B.J, McGechie D.B, Rogers P.A, Glancy R.J. Pyloric campylobacter infection and gastroduodenal disease. Med J Aust (1985); 142: 439-444.

 
 
 
 
 
 
 
 
 
 
 
 
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