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ASSOCIAÇAO DA QUIMIOTOXICIDADE COM O ESTADO <I>(DE LA QUIMIOTOXICIDAD CON EL ESTADO)</I> NUTRICIONAL EM PACIENTES ONCOLOGICOS
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ASSOCIAÇAO DA QUIMIOTOXICIDADE COM O ESTADO (DE LA QUIMIOTOXICIDAD CON EL ESTADO) NUTRICIONAL EM PACIENTES ONCOLOGICOS

(especial para SIIC © Derechos reservados)
O estudo encontrou uma (El estudio encontró una) associação significativa entre a toxicidade gastrointestinal e a perda de peso durante o (y la pérdida de peso durante el) tratamento.
Autor:
Ilanna Marques Gomes Da Rocha
Columnista Experta de SIIC

Institución:
Universidade Federal de Pernambuco


Artículos publicados por Ilanna Marques Gomes Da Rocha
Coautores
Isis Suruagy Correia Moura* Marcella Campos Lima da Luz* Cláudia Porto Sabino Pinho* Itala Farias Cronemberger* Luiz Alberto Reis Mattos Junior** Abel da Costa Neto*** 
Nutricionista, Universidade Federal de Pernambuco, Recife, Brasil*
Médico, Universidade Federal de Pernambuco, Recife, Brasil**
Médico, Hospital das Clínicas, São Paulo, Brasil***
Recepción del artículo
25 de Noviembre, 2016
Aprobación
12 de Julio, 2018
Primera edición
25 de Julio, 2018
Segunda edición, ampliada y corregida
1 de Diciembre, 2021

Resumen
Introdução: O câncer é uma enfermidade caracterizada pelo (El cáncer es una enfermedad que se caracteriza por el) crescimento desordenado de células, cujo tratamento com quimioterapia atua no seu controle ou (cuyo tratamiento con quimioterapia actúa en su control o) remissão e pode prolongar a sobrevida. No entanto (Sin embargo), a quimioterapia pode causar uma série de efeitos colaterais, denominados quimiotoxicidade, levando ao déficit nutricional e comprometendo sua tolerância e (llevando al déficit nutricional y comprometiendo su tolerancia y) eficácia. Objetivo: Verificar a associação da quimiotoxicidade com o estado nutricional de pacientes oncológicos. Métodos: Estudo transversal, de caráter retrospectivo, com análise de prontuário (con análisis de historia clínica) de pacientes com neoplasia de tumores sólidos, com 3 ciclos realizados de quimioterapia. Foram coletadas variáveis (Fueron contempladas variables) sociodemográficas, clínicas, antropométricas e a quimiotoxicidade foi categorizada conforme a National Cancer Institute (NCI). Resultados: Foram avaliados 126 pacientes, com idade média 54.6 ± 13.9 anos, predominantemente do sexo feminino (68.3%). As neoplasias mais prevalentes foram mama (51%) e trato gastrointestinal (34.5%) e o estadiamento IV foi prevalente (con prevalencia del estadio IV) (40.5%). A quimiotoxicidade apresentou-se desde o primeiro ciclo, com 52.5% de toxicidade bioquímica. Comparando o primeiro e terceiro ciclo não foi observada associação significativa entre a toxicidade e o índice de massa corporal (IMC), leucócitos, plaquetas e hemoglobina, mas observou-se tendência na toxicidade (pero se observó una tendencia en la toxicidad) de neutrófilos (p = 0.053). A toxicidade gastrointestinal afetou significativamente a perda de peso durante o (la pérdida de peso durante el) tratamento (p = 0.024). Conclusão: A quimiotoxicidade foi observada desde o primeiro ciclo, no entanto apenas a toxicidade do trato gastrointestinal apresentou (sin embargo, solo la toxicidad del tracto gastrointestinal presentó una) associação com a perda de peso corporal.

Palabras clave
estado nutricional, toxicidade, quimioterapia, nutrição, oncologia, oncología, nutrición, quimioterapia, toxicidad, estado nutricional


Artículo completo

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Abstract
Introduction: Cancer is a disease characterized by the uncontrolled growth of cells, whose treatment with chemotherapy acts as a control or remission and may prolong survival. However, chemotherapy can cause a number of side effects, called chemotoxicity, leading to malnutrition and compromising its effectiveness and tolerance. Objective: To investigate the association between chemotoxicity and the nutritional status of cancer patients. Methods: Longitudinal and retrospective study with chart analysis of patients with cancer of solid tumors, with at least 3 cycles of chemotherapy performed. Sociodemographic, clinical, anthropometric variables were collected and chemotoxicity was categorized according to the National Cancer Institute (NCI, 1999). Results: We evaluated 126 patients, mean age of 54.6 ± 13.9 years, predominantly female (68.3%). The most common cancers were breast (51%) and gastrointestinal tract (34.5%) and most were classified as stage IV (40.5%). Chemotoxicity showed up from the first cycle, with 52.5% biochemical toxicity. Comparing the first and the third cycles, no difference in toxicity was observed in relation to body mass index (BMI), white blood cells, platelets and hemoglobin; but there was a trend in the association of toxicity with neutrophils (p = 0.053). The GI toxicity significantly affected weight loss during treatment (p = 0.024). Conclusion: chemotoxicity was observed from the first cycle; however only the toxicity of the gastrointestinal tract was associated with weight loss.

Key words
nutritional status, toxicity, chemotherapy, nutrition, oncology


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Nutrición, Oncología
Relacionadas: Enfermería, Epidemiología



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Enviar correspondencia a:
Ilanna Marques Gomes da Rocha, 50670-901, Tv. Prof. Morães Rêgo, 1235, Recife, Brasil
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