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TRATAMIENTO DE LA ISQUEMIA CEREBRAL GLOBAL EN JERBOS DE MONGOLIA

TRATAMIENTO DE LA ISQUEMIA CEREBRAL GLOBAL EN JERBOS DE MONGOLIA

(especial para SIIC © Derechos reservados)
El tratamiento con dosis orales únicas de las combinaciones policosanol (100 mg/kg) más aspirina (60 mg/kg) y policosanol (100 mg/kg) más atorvastatina (20 mg/kg) redujo marcada y significativamente la isquemia cerebral global en jerbos de Mongolia, con una eficacia muy similar entre ellos, pero ligeramente superior a la obtenida con la monoterapia con aspirina. Además, ambas combinaciones presentaron efectos antioxidantes, a diferencia de la monoterapia con aspirina, lo que les proporciona un beneficio adicional.
Autor:
Vivian Molina
Columnista Experta de SIIC

Institución:
Centro Nacional de Investigaciones Científicas


Artículos publicados por Vivian Molina
Coautores
Licet Mena Valdés* Miriam Noa Puig** Ambar Oyarzábal Yera* Zullyt Zamora Rodríguez*** 
Farmacéutica, Centro Nacional de Investigaciones Científicas, La Habana, Cuba*
Médica, Centro Nacional de Investigaciones Científicas, La Habana, Cuba**
Doctora en veterinaria, Centro Nacional de Investigaciones Científicas, La Habana, Cuba***
Aprobación
24 de Mayo, 2018
Primera edición
4 de Junio, 2018
Segunda edición, ampliada y corregida
22 de Mayo, 2019

Resumen
El ictus isquémico es un problema de salud relevante a nivel mundial, por lo que la búsqueda de nuevas alternativas terapéuticas es un problema actual. El objetivo de este estudio fue comparar la eficacia terapéutica de policosanol más aspirina (AAS), policosanol más atorvastatina y AAS en la isquemia cerebral global en jerbos de Mongolia. Los jerbos se dividieron en cinco grupos: un control negativo (vehículo) sin isquemia cerebral (IC) y cuatro grupos con IC: control positivo (vehículo), policosanol (100 mg/kg) más AAS (60 mg/kg), policosanol (100 mg/ kg) más atorvastatina (20 mg/kg) y AAS (60 mg/kg). Todos los tratamientos se administraron después de la inducción de IC. Se analizaron los síntomas clínicos (SC), actividad de locomoción, puntaje histológico (PH) y concentraciones plasmáticas de malondialdehído (MDA) y grupos sulfhidrilos (GSH). Tanto el policosanol más AAS, como el policosanol más atorvastatina y el AAS redujeron significativamente los SC (66.5%, 65.2% y 56.5%, respectivamente), la hiperlocomoción (73.5%, 61.04% y 37.8%, en ese orden) y el PH (44%, 44% y 35.9%, respectivamente). Ambas terapias combinadas redujeron significativamente las concentraciones plasmáticas de MDA (77% y 78.2% de inhibición, en igual orden) y GSH (55.2% y 60.3% de inhibición, respectivamente), pero AAS no lo modificó. Las combinaciones terapéuticas de policosanol más aspirina y policosanol más atorvastatina protegieron de forma similar contra la isquemia cerebral en los jerbos de Mongolia, y fueron ligeramente superiores a la monoterapia con aspirina. Ambas combinaciones presentaron efectos antioxidantes, a diferencia de la monoterapia con aspirina, lo que les proporciona un beneficio adicional.

Palabras clave
aspirina, atorvastatina, policosanol, isquemia cerebral, combinaciones terapéuticas


Artículo completo

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Extensión:  +/-6.35 páginas impresas en papel A4
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Abstract
Ischemic stroke is a relevant health problem worldwide, but until now pharmacological treatments have not achieved a significant impact in the reduction of stroke recurrence at the same time that their use is associated with different adverse events, so the search for new therapeutic alternatives is a current problem. This study was aimed to compare the therapeutic efficacy of policosanol plus aspirin (ASA), policosanol plus atorvastatin and ASA on global cerebral ischemia in Mongolian gerbils. Gerbils were divided into 5 groups: a negative control (vehicle) without cerebral ischemia (CI) and 4 groups with CI: positive control (vehicle), policosanol (100 mg/kg) plus ASA (60 mg/kg), policosanol (100 mg/kg) plus atorvastatin (20 mg/kg), and ASA (60 mg/kg). All treatments were administered after CI induction. Clinical symptoms (CS), locomotion activity, histological score (HS) and plasma malondialdehide (MDA) and sulphidriles groups (GSH) were assayed. Policosanol plus ASA, policosanol plus atorvastatin, and ASA reduced significantly the CS (66.5%, 65.2%, and 56.5%, respectively), the hyper-locomotion (73.5%, 61.04% and 37.8%, respectively), the HS (44%, 44% and 35.9%, respectively). Both combined therapies significantly reduced MDA (77% and 78.2% inhibition, respectively) and GSH (55.2% and 60.3% inhibition, respectively) plasma concentrations, but ASA did not modify it. Therapeutic combination policosanol plus aspirin and policosanol plus atorvastatin similarly protected against cerebral ischemia in Mongolian gerbils, being slightly higher than aspirin monotherapy. Both combinations presented antioxidant effects, unlike monotherapy with aspirin, which gives them an additional benefit.

Key words
aspirin, atorvastatin, policosanol, cerebral ischemia, therapeutic combinations


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Farmacología, Neurología
Relacionadas: Anatomía Patológica, Bioquímica, Epidemiología, Medicina Farmacéutica, Medicina Interna



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