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LA HIDROXICLOROQUINA ES DE GRAN UTILIDAD EN EL TRATAMIENTO DEL LUPUS ERITEMATOSO SISTEMICO

LA HIDROXICLOROQUINA ES DE GRAN UTILIDAD EN EL TRATAMIENTO DEL LUPUS ERITEMATOSO SISTEMICO

(especial para SIIC © Derechos reservados)
La hidroxicloroquina es un fármaco fundamental en el tratamiento del lupus eritematoso sistémico, no sólo por su efecto inmunomodulador e inmunusupresor, sino por otras propiedades pleoitrópicas (metabólicas y antitrombóticas). Es un fármaco seguro incluso durante el embarazo y la lactancia.
jimenezalonso9.jpg Autor:
Juan Jiménez Alonso
Columnista Experto de SIIC

Institución:
Unidad de Enfermedades Autoinmunes Sistémicas. Servicio de Medicina Interna. Hospital Universitario Virgen de las Nieves


Artículos publicados por Juan Jiménez Alonso
Coautor
José Mario Sabio* 
Doctor en Medicina, Unidad de Enfermedades Autoinmunes Sistémicas. Hospital Universitario Virgen de las Nieves, Granada, España*
Recepción del artículo
14 de Julio, 2006
Aprobación
24 de Agosto, 2006
Primera edición
31 de Octubre, 2006
Segunda edición, ampliada y corregida
2 de Noviembre, 2007

Resumen
La utilidad de la hidroxicloroquina en el tratamiento del lupus eritematoso sistémico está ampliamente demostrada. Es un fármaco seguro (incluso durante el embarazo y la lactancia), bien tolerado y económico. La retinopatía asociada a su uso es el único efecto adverso realmente peligroso por cuanto puede provocar ceguera irreversible, que puede evitarse mediante un adecuad control oftalmológico. Existen suficientes datos que respaldan el notable efecto que tiene la hidroxicloroquina sobre el control de la actividad de la enfermedad. También hay evidencias que sugieren que disminuye el daño acumulado en los pacientes lúpicos y podría aumentar su supervivencia. Las propiedades de la hidroxicloroquina parecen ir más allá de su efecto inmumodulador e inmunosupresor. Así, tiene efectos beneficiosos sobre el metabolismo lipídico y glucémico y efectos antitrombóticos que podrían contribuir a prevenir la aterosclerosis.

Palabras clave
Hidroxicloroquina, antipalúdicos, lupus eritematoso sistémico


Artículo completo

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Abstract
The positive effects of hydroxychloroquine in treating systemic lupus erythematosus is well known. Hydroxychloroquine is a well tolerated and safe drug even during pregnancy and breast feeding, and it has a low cost. Retinopathy is the most serious side-effect associated with its use since irreversible blindness can occur; therefore, an appropriate monitoring of the eye by an ophthalmologist becomes essential. The remarkable effectiveness of hydroxychloroquine to control disease activity has been demonstrated; and there is also evidence suggesting that this drug contributes to prevent damage accrual and to improve survival in lupus patients. Besides the immunomodulating and immunosuppressant properties of hydroxychloroquine, it also has beneficial effects on lipid and glucose metabolism as well as antithrombotic effects that could contribute to prevent arteriosclerosis in these patients.

Key words
Hydroxychloroquine, antimalarials, systemic lupus erythematosus


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Reumatología
Relacionadas: Farmacología, Medicina Farmacéutica, Medicina Interna



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Enviar correspondencia a:
Juan Jiménez Alonso, Hospital Universitario Virgen de las Nieves, 18012, Avda. Fuerzas Armadas 2. Servicio de Medicina Interna. 9ª Planta, Granada, España
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