Rodolfo A. Rey *

Autor invitado por SIIC

DIAGNÓSTICO DIFERENCIAL ENTRE HIPOGONADISMO HIPOGONADOTRÓFICO Y RETRASO PUBERAL SIMPLE EN VARONES CON NIVELES BASALES DE FSH

Niveles basales de FSH < 1.2 UI/l confirman el diagnóstico de hipogonadismo hipogonadotrófico, sin necesidad de otra prueba diagnóstica, en varones con pubertad ausente o incompleta. En casos de niveles de FSH > 1.2 UI/l, el valor pico de FSH y LH luego de una infusión de GnRH tiene alta exactitud diagnóstica.

*Rodolfo A. Rey
describe para SIIC los aspectos relevantes de su trabajo
BASAL FOLLICLE-STIMULATING HORMONE AND PEAK GONADOTROPIN LEVELS AFTER GONADOTROPIN-RELEASING HORMONE INFUSION SHOW HIGH DIAGNOSTIC ACCURACY IN BOYS WITH SUSPICION OF HYPOGONADOTROPIC HYPOGONADISM
Institución principal de la investigación
*Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina
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Referencias bibliográficas
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3. Sedlmeyer IL, Palmert MR. Delayed puberty: analysis of a large case series from an academic center. J Clin Endocrinol Metab 87:1613-1620, 2002.
4. Grinspon RP, Rey RA. Anti-Müllerian hormone and Sertoli cell function in paediatric male hypogonadism. Horm Res Paediatr 73:81-92, 2010.
5. Sequera AM, Fideleff HL, Boquete HR, Pujol AB, Suárez MG, Ruibal GF. Basal ultrasensitive LH assay: a useful tool in the early diagnosis of male pubertal delay? J Pediatr Endocrinol Metab 15:589-596, 2002.
6. Odink RJ, Schoemaker J, Schoute E, Herdes E, Delemarre-Van de Waal HA. Predictive value of serum follicle-stimulating hormone levels in the differentiation between hypogonadotropic hypogonadism and constitutional delay of puberty. Horm Res 49:279-287, 1988.
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Otros artículos de Rodolfo A. Rey

1. Rey R, Campo S, Bedecarrás P, Nagle C, Chemes H. Is infancy a quiescent period of testicular development? Histological, morphometric, and functional study of the seminiferous tubules of the cebus monkey from birth to the end of puberty. J Clin Endocrinol Metab 76:1325-31, 1993.
2. Rey R, Lordereau-Richard I, Carel JC, Barbet P, Cate RL, Roger M, Chaussain JL, Josso N. Anti-Müllerian hormone and testosterone serum levels are inversely related during normal and precocious pubertal development. J Clin Endocrinol Metab 77:1220-6, 1993.
3. Al-Attar L, Noël K, Dutertre M, Belville C, Forest MG, Burgoyne PS, Josso N, Rey R. Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse. J Clin Invest 100:1335-1343, 1997.
4. Young J, Rey R, Couzinet B, Chanson P, Josso N, Schaison G. Antimüllerian hormone in patients with hypogonadotropic hypogonadism. J Clin Endocrinol Metab 84:2696-2699, 1999.
5. Lukas-Croisier C, Lasala C, Nicaud J, Bedecarrás P, Kumar TR, Dutertre M, Matzuk MM, Picard JY, Josso N, Rey R. Follicle stimulating hormone increases testicular anti-Müllerian hormone (AMH) production through Sertoli cell proliferation and a non-classical cyclic AMP-mediated activation of the AMH gene. Mol Endocrinol 17:550-561, 2003.
6. Young J, Chanson P, Salenave S, Noël M, Brailly S, O'Flaherty M, Schaison G, Rey R. Testicular anti-Müllerian hormone (AMH) secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab 90:724-728, 2005.
7. Rey R, Venara M, Coutant R, Trabut JB, Rouleau S, Lahlou N, Sultan C, Limal JM, Picard JY, Lumbroso S. Unexpected mosaicism of R201H-GNAS1 mutant-bearing cells in the testes underlie macro-orchidism without sexual precocity in McCune-Albright syndrome. Hum Molec Genet 15:3538-3543, 2006.
8. Bergadá I, Milani C, Bedecarrás P, Andreone L, Ropelato MG, Gottlieb S, Bergadá C, Campo S, Rey R. Time course of the serum gonadotropin surge, inhibins and anti-müllerian hormone (AMH) in normal newborn males during the first month of life. J Clin Endocrinol Metab 91:4092-4098, 2006.
9. Chemes HE, Rey RA, Nistal M, Regadera J, Musse M, González-Peramato P, Serrano A. Physiologic androgen insensitivity of the fetal, neonatal and early infantile testis is explained by the ontogeny of the androgen receptor expression in Sertoli cells. J Clin Endocrinol Metab 93:4408-4412, 2008.
10. Grinspon R, Rey R. Anti-Müllerian hormone and Sertoli cell function in paediatric male hypogonadism. Hormone Research 73:81-92, 2009.

Para comunicarse con Rodolfo A. Rey mencionar a SIIC como referencia:
rodolforey@cedie.org.ar

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DIAGNÓSTICO DIFERENCIAL ENTRE HIPOGONADISMO HIPOGONADOTRÓFICO Y RETRASO PUBERAL SIMPLE EN VARONES CON NIVELES BASALES DE FSH

Título original en castellano
ALTA EXACTITUD DIAGNOSTCA DEL NIVEL BASAL DE HORMONA FOLICULO-ESTIMULANTE (FSH) Y DEL PICO DE GONADOTROFINAS LUEGO DE LA INFUSION CON HROMONA LIBERADORA DE GONADOTROFINAS (GNRH) EN VARONES CON SOSPECHA DE HIPOGONADISMO HIPOGONADOTROFICO

Autor
Rodolfo A. Rey¹
1 Médico, Centro de Investigaciones Endocrinológicas (cedie-conicet), División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina, Investigador del Consejo Nacional de Inv

Acceso a la fuente original
Journal of Clinical Endocrinology and Metabolism
http://jcem.endojournals.org