Martín Jesús García González *

Autor invitado por SIIC

Revisión sobre la utilidad potencial del levosimendan como agente terapéutico en la insuficiencia cardíaca generada por el atontamiento miocárdico de origen isquémico

TRATAMIENTO FARMACOLOGICO DEL ATONTAMIENTO MIOCARDICO: PAPEL POTENCIAL DEL LEVOSIMENDAN

El atontamiento miocárdico que se desencadena en el contexto de la reperfusión coronaria en los síndromes isquémicos agudos puede dar lugar a una situación de insuficiencia cardíaca, e incluso shock cardiogénico, cuyo tratamiento constituye un desafío clínico. El levosimendán, agente sensibilizante al calcio posee propiedades farmacocinéticas, farmacodinámicas y un perfil de seguridad que podrían ser de gran utilidad el tratamiento de esta situación clínica.

*Martín Jesús García González
describe para SIIC los aspectos relevantes de su trabajo
PHARMACOLOGIC TREATMENT OF HEART FAILURE DUE TO VENTRICULAR DYSFUNCTION BY MYOCARDIAL STUNNING
Institución principal de la investigación
*Hospital Universitario de Canarias, Tenerife, España
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Otros artículos de Martín Jesús García González

García González MJ, Domínguez Rodríguez A, Ferrer Hita JJ. Utility of levosimendan, a new calcium sensitizing agent, in the treatment of cardiogenic shock due to myocardial stunning in patients with st elevation myocardial infarction: a series of cases. J Clin Pharmacol 2005; 45:704-708.
García González MJ, Domínguez Rodriguez A, Abreu González P. Diurnal variations in serum neopterin levels are associated with the pineal hormone melatonin circadian rhythm in healthy human subjects. J Pineal Res 2006; 40(3):288-9.
García González MJ, Domínguez Rodríguez A, Ferrer Hita JJ, Abreu González P, Bethencourt Muñoz M. Cardiogenic shock after primary percutaneous coronary intervention: Effects of levosimendan compared with dobutamine on haemodynamics. Eur J Heart Fail 2006; 8:723-728.
Domínguez Rodríguez A, García González M, Abreu González P, Ferrer J, Kaski JC. Relation of nocturnal melatonin levels to C-reactive protein concentration in patients with ST-segment elevation myocardial infarction. Am J Cardiol 2006; 97(1):10-12.
Domínguez Rodríguez A, Abreu González P, García González NJ, Ferrer Hita JJ. Asociación entre concentraciones séricas de interleucina 10 y desarrollo de insuficiencia cardíaca en pacientes con infarto agudo de miocardio tratados con angioplastia primaria. Rev Esp Cardiol 2005; 58(6):626-630.
Domínguez Rodríguez A, Abreu González P, García González MJ, Ferrer J, Vargas M. Circulating pregnancy-associated plasma protein A is not an early marker of acute myocardial infarction. Clinical Biochemistry 2005; 38:180-182.
Domínguez Rodríguez A, Abreu González P, García González MJ, Ferrer Hita J, Vargas M, Reiter RJ. Elevated levels of oxidized low-density lipoprotein and impaired nocturnal síntesis of melatonin in patients with myocardial infarction. Atherosclerosis 2005; 180:101-105.
Domínguez Rodríguez A, Abreu González P, García González M. Usefulness of neopterin levels and left ventricular function for risk assessment in survivors of acute myocardial infarction. Int J Cardiol 2006; 111:318-320.
Domínguez Rodríguez A, Abreu González P, García González M, Ferrer J. Prognostic value of interleukin-8 as a predictor of heart failure in patients with myocardial infarction and percutaneous intervention. Int J Cardiol 2006; 111:158-160.
Domínguez Rodríguez A, Abreu González P, García González M, Reiter RJ. Prognostic value of nocturnal melatonin levels as a novel marker in patients with ST-segment elevation myocardial infarction. Am J Cardiol 2006; 97:1162-1164.

Para comunicarse con Martín Jesús García González mencionar a SIIC como referencia:
mjgg181262@hotmail.com

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Acerca del trabajo completo

TRATAMIENTO FARMACOLOGICO DEL ATONTAMIENTO MIOCARDICO: PAPEL POTENCIAL DEL LEVOSIMENDAN

Título original en castellano
Tratamiento FarmacolOgico de la Insuficiencia Cardiaca debida a DisfunciOn Ventricular por Aturdimiento MiocArdico. Papel potencial del Levosimendan

Autor
Martín Jesús García González¹, Alberto Domínguez Rodríguez²
1 Médico, Coronary Care Unit, Department of Cardiology, Hospital Universitario de Canarias, Tenerife, España, Médico Adjunto
2 Médico, Hospital Universitario de Canarias, Tenerife, España, Médico Adjunto

Acceso a la fuente original
American Journal of Cardiovascular Drugs
http://link.springer.com/journal/40256

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