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CONTROVERSIAS ACERCA DE LA TEORIA TH2 EN ALERGIA

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CONTROVERSIAS ACERCA DE LA TEORIA TH2 EN ALERGIA

(especial para SIIC © Derechos reservados)
El desarrollo de bloqueadores de moléculas coestimuladoras parece ser un campo promisorio, al igual que el de los receptores de las células tipo toll, además de los componentes genéticos que confieren susceptibilidad a la producción de citocinas tipo Th2.
rojasra9.jpg Autor:
Rojas Ramos, Enrique
Columnista Experto de SIIC

Institución:
Departamento de Inmunología Clínica y Alergia Hospital Regional 1º de Octubre Instituto de Seguridad Social al Servicio del Estado (ISSSTE) México DF, México

Artículos publicados por Rojas Ramos, Enrique
Coautores
Norma E. Martínez Jimúnez, MD, MSc*  María de Lourdes García Moreno, MD*  Carlos Colin Núñez, MD* 
ISSSTE*
Recepción del artículo
13 de Septiembre, 2004 		Aprobación
1 de Octubre, 2004
Primera edición
3 de Marzo, 2005 		Segunda edición, ampliada y corregida
7 de Junio, 2021

CONTROVERSIAS ACERCA DE LA TEORIA TH2 EN ALERGIA

Resumen
Los padecimientos alérgicos han sido un modelo de estudio para la polarización de células Th2 y es bien sabido que la síntesis de la IgE humana surge de la colaboración entre las células Th2 y las células B a través de la participación de citocinas como la IL-4 y la IL-13 y moléculas de superficie como CD40-CD40L. En la última década, algunas moléculas de superficie han sido asociadas con células Th2 humanas. Aunque estudios recientes sugieren que los receptores de quimiocinas son los marcadores más relacionados con células Th2, hasta la fecha no se encontró un marcador específico para las células Th2. Los estudios más recientes sugieren, en primer término, que las células Th1 y Th2 no son derivadas de distintos linajes celulares sino que pueden derivarse del mismo precursor Th y, bajo la influencia de factores genéticos y medioambientales, polarizarse y convertirse en células Th1, Th2 y las llamadas Th3 o reguladoras. Por otro lado, el desarrollo de bloqueadores de moléculas coestimuladoras parece ser un campo promisorio, al igual que el de los receptores de las células tipo toll, además de los componentes genéticos que confieren susceptibilidad a la producción de citocinas tipo Th2.

Palabras clave
Alergia, teoria Th2, citocinas, marcadores de superficie, genes


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Especialidades
Principal: Alergia
Relacionadas: Atención Primaria, Bioquímica, Diagnóstico por Laboratorio, Inmunología, Medicina Interna



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Bibliografía del artículo
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