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La creciente cantidad de artículos con Acceso Abierto (Open
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tanta abundancia, complica al lector en su encuentro con los estudios
fundamentales. Para facilitarlo, profesionales biomédicos de SIIC
consultan diariamente una profusa cantidad de documentos que nutrirán
Textos completos autorizados (TCA).
Las citas de la sección TCA enlazan de manera legal, autorizada y
gratuita con los textos completos (full text) publicados en
los sitios oficiales de sus respectivas fuentes.
SIIC creó, produjo y opera con exclusividad el software TCA para la
interpretación de los diversos campos documentales que integran la
estructura de un estudio: especialidad, modalidad del estudio,
fuente, fechas de publicación y selección, definición de la fuente,
limitaciones de consulta, resumen en castellano, etc.
Si bien la mayoría de los textos seleccionados corresponden a
artículos originales, revisiones y guías, los lectores también
encontrarán comentarios, entrevistas, notas periodísticas, cartas a
autores u otros textos precursores de debates o aclaratorios.
Sociedad Iberoamericana de Información Científica (SIIC) selects
complete quality-full texts which have been recently published in
renowned sources worldwide and are indexed by SIIC Data
Bases.
The increasing number of Open Access articles widens the reading offer
but, also, such myriad complicates the readers search of fundamental
articles. To facilitate this, SIIC biomedical professionals daily
consult a profuse amount of documents that will feed
Authorized Full Texts (TCA, Spanish acronym).
The citations of the AFT section link legally, authorized and free of
charge with the full texts published in the official web sites of
their corresponding sources.
SIIC created, produced and handles the AFT software that deciphers
the various documentary fields that form part of the structure of a
study: specialty, study style, source, publication and selection
dates, source definition, query limitations, summary in Spanish,
etc.
While most of the selected texts belong to original articles,
reviews, and guidelines, readers will also find commentaries,
interviews, journalistic reports, letters to authors or other texts
that may lead to discussions or clarifications.
New insights into the cultivability of human milk bacteria from ingestion to digestion and implications for their Immunomodulatory properties.
New insights into the cultivability of human milk bacteria from ingestion to digestion and implications for their Immunomodulatory properties.
Fuente:Scientific Reports
Extracto:
These
results highlight the potential of HM bacteria to survive during the infant
gastrointestinal digestion and interact with the intestinal epithelium and immune
system, as well as the importance of considering the digestion process when
evaluating host-bacteria interactions.
Claves:Bacterial cultivability, Bacterial viability, Breast milk microbiota, Gastrointestinal digestion, Immunomodulatory properties, In vitro digestion
Cita:Sci Rep 2025 Mar 31; 15 (1) : 10985.
Autor/es:Le Bras, Charles (a) Mouchard, Alizé (b)
institución:(a) STLO, INRAE, Institut Agro Rennes Angers, Rennes, France. (b) Institut NuMeCan, INRAE, INSERM, Université de Rennes, Saint Gilles, France.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Case report: a case of R0 resection in a patient with PD-L1-negative, microsatellite-stabilized advanced pancreatic cancer after down-stage treatment with a PD-1 inhibitor in combination with chemotherapy.
Case report: a case of R0 resection in a patient with PD-L1-negative, microsatellite-stabilized advanced pancreatic cancer after down-stage treatment with a PD-1 inhibitor in combination with chemotherapy.
Fuente:Journal of Cancer Research and Clinical Oncology
Extracto:
PD-1 antibody combination chemotherapy regimens have significant
efficacy and do not add additional side effects in UR-PDAC patients, heralding
advances in UR-PDAC treatment. We may have a way to give UR-PDAC patients access
to curative treatment and long-term survival. This case of UR-PDAC patient with
PD-L1-negative and microsatellite stability (MSS) gives us a more comprehensive
understanding of the treatment options of immune-combination chemotherapy.
Cita:J Cancer Res Clin Oncol 2025 Mar 31; 151 (4) : 128.
Autor/es:Dang, Junqiang (a) Wang, Qingqiang (b)
institución:(a) Department of Hepatobiliary Surgery, Xi'an Daxing Hospital Affiliated to Yan'an University, Xi'an, Shaanxi Province, China. (b) Department of Hepatobiliary and Pancreatic Surgery, Xijing Hospital Affiliated to Air Force Medical University, Xi'an, Shaanxi Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Whole genome sequencing and analysis of the symbiotic Armillaria gallica M3 with Gastrodia elata.
Whole genome sequencing and analysis of the symbiotic Armillaria gallica M3 with Gastrodia elata.
Fuente:Bmc Genomics
Extracto:
These
results have elucidated the characteristics of A. gallica M3 from a genomic
perspective to a certain extent. They help to analyze the inner mechanism of A.
gallica M3 being able to symbiosis with G. elata at the genomic level, which is
of great significance to the next related research of A. gallica M3.
institución:(a) Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China. (b) Gastrodia Industry Development Center of Yiliang County, Zhaotong, 657000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
In vitro susceptibility of clinical Clostridioides difficile isolates in Israel to metronidazole, vancomycin, fidaxomicin, ridinilazole and ibezapolstat.
In vitro susceptibility of clinical Clostridioides difficile isolates in Israel to metronidazole, vancomycin, fidaxomicin, ridinilazole and ibezapolstat.
Fuente:Bmc Gastroenterology
Extracto:
RDZ and IBZ
demonstrated potent in vitro activity against 313 C. difficile isolates belonging
to different STs. These two antimicrobials may serve as effective agents for C.
difficile infection.
institución:(a) Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel. (b) Clinical Microbiology Laboratory, The Edith Wolfson Medical Center, Holon, Israel, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cefepime versus carbapenem for treating complicated urinary tract infection caused by cefoxitin-nonsusceptible ESCPM organisms: a multicenter, real-world study.
Cefepime versus carbapenem for treating complicated urinary tract infection caused by cefoxitin-nonsusceptible ESCPM organisms: a multicenter, real-world study.
Fuente:Bmc Infectious Diseases
Tipo de trabajo:Revisión
Extracto:
The
cefepime and carbapenem had comparable efficacy for treating cUTI caused by
cefoxitin-nonsusceptible ESCPM organisms with cefepime MIC ≤ 1 µg/mL, whereas
carbapenems are potentially more effective for isolates with cefepime
MIC = 2 µg/mL.
institución:(a) Department of Infectious Diseases, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical College of Nanjing University, No.300 Guangzhou Road, Nanjing, 210029, China. (b) Department of Infectious Diseases, Nanjing Lishui People's Hospital, Nanjing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Deciphering the integrated immunogenomic landscape of colorectal cancer: insights from Mendelian randomization and immune-stratified molecular subtyping.
Deciphering the integrated immunogenomic landscape of colorectal cancer: insights from Mendelian randomization and immune-stratified molecular subtyping.
Fuente:Bmc Gastroenterology
Tipo de trabajo:Consenso
Extracto:
Genetic
interrogation delineated causal immunome-CRC relationships at single-cell
resolution. Immune-stratified CRC subtyping stratified patient outcomes. GPD1L
exhibited tumor-suppressive functions. Our findings establish an integrated
immunogenomic framework elucidating CRC pathogenesis with implications for
precision immunotherapies.
institución:(a) The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou city, Zhejiang Province, China. hekejie@stu.xmu.edu.cn. (b) School of Medicine, Xiamen University, Xiamen, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The usefulness of percutaneous bile duct metal stent insertion for malignant biliary obstruction: a retrospective study.
The usefulness of percutaneous bile duct metal stent insertion for malignant biliary obstruction: a retrospective study.
Fuente:Bmc Gastroenterology
Tipo de trabajo:Revisión
Extracto:
The stent can be safely inserted in a one-stage procedure without
compromising the patient's quality of life. Therefore, one-stage insertion of EMS
for malignant biliary stricture may be performed aggressively unless the patient
has severe cholangitis.
Claves:Malignant biliary obstruction, One-phase insert, Percutaneous bile duct metal stent
Cita:BMC Gastroenterol 2025 Mar 31; 25 (1) : 211.
Autor/es:Izumi, Hideki (a) Yoshii, Hisamichi (b)
institución:(a) Department of Gastrointestinal Surgery, Tokai University Hachioji Hospital, 1838 Ishikawa, Hachioji, Tokyo, 192-0032, Japan. h_izumy@tokai.ac.jp. (b) Department of Gastrointestinal Surgery, Tokai University Hachioji Hospital, 1838 Ishikawa, Hachioji, Tokyo, 192-0032, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical application and effectiveness analysis of modified Asia-Pacific colorectal cancer screening score combined with fecal occult blood test for colorectal cancer screening in asymptomatic population.
Clinical application and effectiveness analysis of modified Asia-Pacific colorectal cancer screening score combined with fecal occult blood test for colorectal cancer screening in asymptomatic population.
Fuente:Bmc Gastroenterology
Extracto:
The
combination of modified APCS score and FOBT test has important clinical
application value in the preliminary screening of colorectal tumors in
asymptomatic population. For selected T1 CRC patients, if the lesion is
ulcerative and the pathology indicates low differentiation, endoscopic submucosal
dissection (ESD) treatment should be carefully selected to prevent the risk of
LNM.
Claves:Colorectal cancer, Early detection, Screening and diagnosis, Tumor
Cita:BMC Gastroenterol 2025 Mar 31; 25 (1) : 212.
Autor/es:Li, Lin (a) Wang, Tianzheng (b)
institución:(a) Departments of Gastroenterology, Yijishan Hospital (The First Affiliated Hospital of Wannan Medical College), Wuhu, 241001, P.R. China. (b) Departments of Gastroenterology, Yijishan Hospital (The First Affiliated Hospital of Wannan Medical College), Wuhu, 241001, P.R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prevalence, associated factors, and clinical outcomes of Helicobacter pylori infection in pediatric populations in a war-torn urban environment in Eastern Democratic Republic of Congo: a mixed methods study.
Prevalence, associated factors, and clinical outcomes of Helicobacter pylori infection in pediatric populations in a war-torn urban environment in Eastern Democratic Republic of Congo: a mixed methods study.
Fuente:Bmc Pediatrics
Extracto:
Children with occult blood in stool and
microcytic anemia should be tested for H. pylori using stool antigen tests.
Treatment with clarithromycin should be guided by local antibiotic resistance
data. Hygiene education, including safe water practices and managing pet contact,
is crucial due to their association with H. pylori infection.
Autor/es:Tibasima, Emmanuel Busha (a) Kumbakulu, Patrick Kumbowi (b)
institución:(a) Department of Paediatrics and Child Health, Université Libre Des Pays Des Grands Lacs, Goma, Democratic Republic of Congo. (b) Department Of Pediatric and Child Health Samaritan Doctor'S Pediatric Centre, Goma, Democratic Republic of Congo.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Academic and clinical perspectives of metagenome sequencing as a diagnostic tool for infectious disease: an interpretive phenomenological study.
Academic and clinical perspectives of metagenome sequencing as a diagnostic tool for infectious disease: an interpretive phenomenological study.
Fuente:Bmc Infectious Diseases
Extracto:
The study provided insights into
stakeholders' perspectives and opinions to address the knowledge gap in current
literature and identified barriers and facilitators which drive the
implementation of metagenome sequencing as a routine IDD in clinical settings.
Knowledge of new and upcoming genomic diagnostic testing is not equally
distributed throughout the UK, impacting the understanding and drive to integrate
metagenome sequencing into routine clinical diagnostics. Improvements in access
to new diagnostics could improve patient treatment and management and positively
impact population health.
Autor/es:Trivett, Hannah (a) Darby, Alistair C (b)
institución:(a) Health Protection Research Unit in Gastrointestinal Infections, University of Liverpool, Liverpool, UK. h.g.trivett@bham.ac.uk. (b) Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Bioscience Building, Liverpool, UK. h.g.trivett@bham.ac.uk.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Predictors of pathological complete response after total neoadjuvant treatment using short course radiotherapy for locally advanced rectal cancer.
Predictors of pathological complete response after total neoadjuvant treatment using short course radiotherapy for locally advanced rectal cancer.
Fuente:Bmc Gastroenterology
Extracto:
Mucinous component and chemotherapy interruption are associated with lower pCR
rates. Integrating these factors into personalized treatment algorithms may help
optimize therapeutic strategies and improve outcomes for patients with LARC.
institución:(a) Gastroenterolgy department, La Rabta Hospital, Tunis, Tunisia. yacoubhaythem@hotmail.com. (b) Faculty of Medicine of Tunis, El Manar university, Tunis, Tunisia. yacoubhaythem@hotmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Inflammatory burden index is correlated with increased depression: a population-based study.
Inflammatory burden index is correlated with increased depression: a population-based study.
Fuente:Bmc Psychiatry
Extracto:
These findings in this study indicate a positive
correlation between IBI and depression in American adults. Further large-scale
prospective studies are still needed to analyze the role of IBI in depression.
Claves:C-reactive protein, Chronic inflammation, Depression, Depressive, Inflammatory burden index
Cita:BMC Psychiatry 2025 Mar 31; 25 (1) : 306.
Autor/es:Shao, Xiangzhi (a) Xie, Zuopu (b)
institución:(a) Department of Rehabilitation, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, No. 9 Jiaowei Road, Lucheng District, Wenzhou city, Zhejiang, P. R. China. (b) Department of Gastroenterology, Pingyang Hospital of Wenzhou Medical University, Pingyang county, Wenzhou city, Zhejiang Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A laboratory-less nomogram predicting survival rates for hospice patients with advanced cancer.
A laboratory-less nomogram predicting survival rates for hospice patients with advanced cancer.
Fuente:Bmc Public Health
Extracto:
This study developed
a laboratory-free nomogram and a web-based calculator for accurately predicting
survival in hospice patients with terminal cancer.
Claves:Cancer pain, Clinical Decision-Making, Palliative care, Prognosis
Cita:BMC Public Health 2025 Mar 31; 25 (1) : 1204.
Autor/es:Li, Haopeng (a) Chen, Xiaofeng (b)
institución:(a) Department of Gastroenterology, The First Affiliated Hospital of Shantou, University Medical College, Shantou, Guangdong, People's Republic of China. (b) Department of Gastroenterology, The First Affiliated Hospital of Shantou, University Medical College, Shantou, Guangdong, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Methylmalonic acidemia with recurrent hemophagocytic lymphohistiocytosis
Methylmalonic acidemia with recurrent hemophagocytic lymphohistiocytosis
Fuente:Bmc Pediatrics
Tipo de trabajo:Revisión
Extracto:
HLH is a rare and underrecognized
hematologic emergency in methylmalonic acidemia, and its early diagnosis and
treatment are critical. Serum ferritin may be a useful clinical biomarker in the
diagnosis of HLH-associated attacks in methylmalonic acidemia.
Autor/es:Bahrizadeh, Mohammad (a) Fotros, Danial (b)
institución:(a) Student Research Committee, Department of Clinical Nutrition and dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. (b) Department of Clinical Nutrition and dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, West Arghavan St. Farahzadi Blvd., Sharake Qods, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Structural and functional alteration of the gut microbiomes in ICU staff: a cross-sectional analysis.
Structural and functional alteration of the gut microbiomes in ICU staff: a cross-sectional analysis.
Fuente:Critical Care (london, England)
Tipo de trabajo:Estudio de cohortes
Extracto:
Our findings indicated that ICU staff exhibited a reduction in gut microbiome
diversity which was associated with an increase in virulence factors and
carbohydrate-active enzymes, as well as with a heightened susceptibility to
endocrine and metabolic diseases and cancers.
Claves:Functional annotation, Gut microbiome, Intensive care unit, Metagenomic sequencing, Microbial dysbiosis
Cita:Crit Care 2025 Mar 31; 29 (1) : 141.
Autor/es:Xie, Bing (a) Dong, Chenyang (b)
institución:(a) Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. (b) Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, 430030, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A novel network-level fused deep learning architecture with shallow neural network classifier for gastrointestinal cancer classification from wireless capsule endoscopy images.
A novel network-level fused deep learning architecture with shallow neural network classifier for gastrointestinal cancer classification from wireless capsule endoscopy images.
Fuente:Bmc Medical Informatics and Decision Making
Extracto:
Future work will
explore its adaptability to additional datasets and optimize its computational
complexity for broader deployment.
Cita:BMC Med Inform Decis Mak 2025 Mar 31; 25 (1) : 150.
Autor/es:Khan, Muhammad Attique (a) Shafiq, Usama (b)
institución:(a) Department of Computer Science and Engineering, College of Computer Engineering and Science, Prince Mohammad Bin Fahd University, Al-Khobar, KSA, Kingdom of Saudi Arabia. attique.khan@ieee.org. (b) Department of Computer Science, HITEC University, Taxila, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease.
The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease.
Fuente:Biology Direct
Extracto:
The PT-dependent ER stress observed in the IECs of CD patients
results from the excessive release of calcium from the ER. Importantly,
inhibition of this signaling pathway abrogates ER stress, which in turn
attenuates downstream signs of CD, such as TG2 expression and gut permeability
dysregulation, as well as inhibits inflammation.
Claves:CD, CXCR3, IEC, IP3R, PKC, UPR
Cita:Biol Direct 2025 Mar 31; 20 (1) : 39.
Autor/es:Monzani, Romina (a) Gagliardi, Mara (b)
institución:(a) Department of Health Sciences, School of Medicine, Center for Translational Research on Autoimmune and Allergic Disease (CAAD), University of Piemonte Orientale, Novara, Italy. (b) Department of Health Sciences, School of Medicine, Center for Translational Research on Autoimmune and Allergic Disease (CAAD), University of Piemonte Orientale, Novara, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment.
Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment.
Fuente:The Journal of Clinical Investigation
Extracto:
Future work to better characterize disease heterogeneity
by combining genetics with clinical risk factors to holistically predict risk and
develop therapies based on genetic risk is required.
Cita:J Clin Invest 2025 Apr 1; 135 (7)
Autor/es:Chen, Vincent L (a) Kuppa, Annapurna (b)
institución:(a) Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. (b) Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Microbial Influences on Calcium-Phosphorus Homeostasis and Metabolic Bone Diseases: A Bidirectional Mendelian Randomisation Study on the Gut-Bone Axis.
Microbial Influences on Calcium-Phosphorus Homeostasis and Metabolic Bone Diseases: A Bidirectional Mendelian Randomisation Study on the Gut-Bone Axis.
Fuente:Journal of Cellular and Molecular Medicine
Extracto:
The study underscores the critical role
of GM in influencing bone health through the gut-bone axis, paving the way for
future therapeutic interventions targeting the gut-bone axis and offering new
directions for research in bone metabolism and diseases.
Claves:Mendelian randomisation, calcium‐phosphorus metabolism, gut microbiota, gut–bone axis, metabolic bone diseases
Cita:J Cell Mol Med 2025 Apr; 29 (7) : e70491.
Autor/es:Zhou, Yanling (a) Yang, Yao (b)
institución:(a) Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. (b) Department of Orthopedics, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
